{"id":"https://openalex.org/W4361895141","doi":"https://doi.org/10.1158/0008-5472.22395608.v1","title":"Supplementary Figure 2 from miRNA-34 Prevents Cancer Initiation and Progression in a Therapeutically Resistant K-ras and p53-Induced Mouse Model of Lung Adenocarcinoma","display_name":"Supplementary Figure 2 from miRNA-34 Prevents Cancer Initiation and Progression in a Therapeutically Resistant K-ras and p53-Induced Mouse Model of Lung Adenocarcinoma","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361895141","doi":"https://doi.org/10.1158/0008-5472.22395608.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22395608.v1","doi":"https://doi.org/10.1158/0008-5472.22395608.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22395608.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_miRNA-34_Prevents_Cancer_Initiation_and_Progression_in_a_Therapeutically_Resistant_K-ras_and_p53-Induced_Mouse_Model_of_Lung_Adenocarcinoma/22395608/1/files/39841235.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_miRNA-34_Prevents_Cancer_Initiation_and_Progression_in_a_Therapeutically_Resistant_K-ras_and_p53-Induced_Mouse_Model_of_Lung_Adenocarcinoma/22395608/1/files/39841235.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082310628","display_name":"Andrea L. Kasinski","orcid":"https://orcid.org/0000-0002-9602-7827","observed_orcids":["https://orcid.org/0000-0002-9602-7827"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea L. Kasinski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013989133","display_name":"Frank John Slack","orcid":"https://orcid.org/0000-0001-8263-0409","observed_orcids":["https://orcid.org/0000-0001-8263-0409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank J. Slack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-34","display_name":"miR-34","score":0.9300000071525574},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.890999972820282},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.828000009059906},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.6620000004768372},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7110000252723694},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.8479999899864197},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5199999809265137},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.68281090259552},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6589200496673584},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6343482136726379},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.563133716583252},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.5548748970031738},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.45832857489585876},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41921183466911316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41330254077911377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40480566024780273},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36708372831344604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3213711977005005},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1432424783706665}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.22395608.v1","doi":"https://doi.org/10.1158/0008-5472.22395608.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22395608.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_miRNA-34_Prevents_Cancer_Initiation_and_Progression_in_a_Therapeutically_Resistant_K-ras_and_p53-Induced_Mouse_Model_of_Lung_Adenocarcinoma/22395608/1/files/39841235.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22395608","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_miRNA-34_Prevents_Cancer_Initiation_and_Progression_in_a_Therapeutically_Resistant_K-ras_and_p53-Induced_Mouse_Model_of_Lung_Adenocarcinoma/22395608","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22395608.v1","doi":"https://doi.org/10.1158/0008-5472.22395608.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22395608.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_miRNA-34_Prevents_Cancer_Initiation_and_Progression_in_a_Therapeutically_Resistant_K-ras_and_p53-Induced_Mouse_Model_of_Lung_Adenocarcinoma/22395608/1/files/39841235.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361895141.pdf","grobid_xml":"https://content.openalex.org/works/W4361895141.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2090944178","https://openalex.org/W4392725903","https://openalex.org/W2388653379","https://openalex.org/W1990258390","https://openalex.org/W2912158592","https://openalex.org/W1985186732","https://openalex.org/W3151821102","https://openalex.org/W2063878022","https://openalex.org/W2037647570","https://openalex.org/W2740267034"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"30K,":[3],"In":[4],"cells":[5],"lines":[6],"with":[7],"mutant":[8],"p53":[9,25],"serum":[10],"withdrawal":[11],"failed":[12],"to":[13,17],"induce":[14],"miR-34":[15,21],"levels":[16],"the":[18],"extent":[19],"that":[20],"was":[22],"induced":[23],"in":[24],"wild-type":[26],"cells.":[27]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-05T00:00:00"}