{"id":"https://openalex.org/W4361892220","doi":"https://doi.org/10.1158/0008-5472.22370991","title":"Supplementary Methods and Materials from Delta-like 4 Notch Ligand Regulates Tumor Angiogenesis, Improves Tumor Vascular Function, and Promotes Tumor Growth In vivo","display_name":"Supplementary Methods and Materials from Delta-like 4 Notch Ligand Regulates Tumor Angiogenesis, Improves Tumor Vascular Function, and Promotes Tumor Growth In vivo","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361892220","doi":"https://doi.org/10.1158/0008-5472.22370991"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22370991","doi":"https://doi.org/10.1158/0008-5472.22370991","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22370991","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.22370991","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101694079","display_name":"Ji\u2010Liang Li","orcid":"https://orcid.org/0000-0001-6200-1007","observed_orcids":["https://orcid.org/0000-0001-6200-1007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ji-Liang Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076265076","display_name":"Richard C.A. Sainson","orcid":"https://orcid.org/0000-0001-5407-9787","observed_orcids":["https://orcid.org/0000-0001-5407-9787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard C.A. Sainson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100760917","display_name":"Wen Shi","orcid":"https://orcid.org/0000-0002-5770-5672","observed_orcids":["https://orcid.org/0000-0002-5770-5672","https://orcid.org/0009-0004-0761-1530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058291433","display_name":"Russell Leek","orcid":"https://orcid.org/0000-0002-8038-8660","observed_orcids":["https://orcid.org/0000-0002-8038-8660"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Russell Leek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062308314","display_name":"Laura S. Harrington","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura S. Harrington","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057141936","display_name":"Matthias Preusser","orcid":"https://orcid.org/0000-0003-3541-2315","observed_orcids":["https://orcid.org/0000-0003-3541-2315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthias Preusser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113635272","display_name":"Swethajit Biswas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Swethajit Biswas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033223978","display_name":"Helen Turley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen Turley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088402992","display_name":"Emily Heikamp","orcid":"https://orcid.org/0000-0002-4591-4477","observed_orcids":["https://orcid.org/0000-0002-4591-4477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily Heikamp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043947003","display_name":"Johannes Andreas Hainfellner","orcid":"https://orcid.org/0000-0002-9148-958X","observed_orcids":["https://orcid.org/0000-0002-9148-958X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johannes A. Hainfellner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079633934","display_name":"Adrian Llewellyn Harris","orcid":"https://orcid.org/0000-0003-1376-8409","observed_orcids":["https://orcid.org/0000-0003-1376-8409","https://orcid.org/0000-0002-5222-4765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adrian L. Harris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/delta-like-ligand-4","display_name":"DLL4","score":0.9369999766349792},{"id":"https://openalex.org/keywords/notch-ligands","display_name":"Notch ligands","score":0.8730000257492065},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.9890000224113464},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.6930000185966492},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8579902052879333},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7414051294326782},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6078622937202454},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6076613664627075},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.5400015711784363},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5383073091506958},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46220114827156067},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43767163157463074},{"id":"https://openalex.org/C5072461","wikidata":"https://www.wikidata.org/wiki/Q49506","display_name":"Delta","level":2,"score":0.42401716113090515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3039589524269104},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17410534620285034},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.135731041431427},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09373298287391663},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0699923038482666},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.059965550899505615},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.22370991","doi":"https://doi.org/10.1158/0008-5472.22370991","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22370991","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.22370991.v1","doi":"https://doi.org/10.1158/0008-5472.22370991.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22370991.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Methods_and_Materials_from_Delta-like_4_Notch_Ligand_Regulates_Tumor_Angiogenesis_Improves_Tumor_Vascular_Function_and_Promotes_Tumor_Growth_i_In_vivo_i_/22370991/1/files/39816078.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22370991","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Methods_and_Materials_from_Delta-like_4_Notch_Ligand_Regulates_Tumor_Angiogenesis_Improves_Tumor_Vascular_Function_and_Promotes_Tumor_Growth_i_In_vivo_i_/22370991","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22370991","doi":"https://doi.org/10.1158/0008-5472.22370991","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22370991","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361892220.pdf","grobid_xml":"https://content.openalex.org/works/W4361892220.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W1990607537","https://openalex.org/W2048907346","https://openalex.org/W2055647863","https://openalex.org/W2073465941","https://openalex.org/W2153726848"],"related_works":["https://openalex.org/W4392678502","https://openalex.org/W2076274098","https://openalex.org/W3021227184","https://openalex.org/W2098041761","https://openalex.org/W55814286","https://openalex.org/W3012204787","https://openalex.org/W181837403","https://openalex.org/W7098659647","https://openalex.org/W3031575538","https://openalex.org/W2123295526"],"abstract_inverted_index":{"Supplementary":[0],"Methods":[1],"and":[2,16],"Materials":[3],"from":[4],"Delta-like":[5],"4":[6],"Notch":[7],"Ligand":[8],"Regulates":[9],"Tumor":[10,13,18],"Angiogenesis,":[11],"Improves":[12],"Vascular":[14],"Function,":[15],"Promotes":[17],"Growth":[19],"In":[20],"vivo":[21]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-05T00:00:00"}