{"id":"https://openalex.org/W4361891345","doi":"https://doi.org/10.1158/1535-7163.22485138","title":"Supplementary Tables 1-3, Figures 1-4 from SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo","display_name":"Supplementary Tables 1-3, Figures 1-4 from SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361891345","doi":"https://doi.org/10.1158/1535-7163.22485138"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22485138","doi":"https://doi.org/10.1158/1535-7163.22485138","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22485138","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.22485138","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037720065","display_name":"Sean G. Buchanan","orcid":"https://orcid.org/0000-0002-5215-4672","observed_orcids":["https://orcid.org/0000-0002-5215-4672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean G. Buchanan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038290615","display_name":"J\u00f6rg Hendle","orcid":"https://orcid.org/0000-0001-8857-0216","observed_orcids":["https://orcid.org/0000-0001-8857-0216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorg Hendle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001174927","display_name":"Patrick S. Lee","orcid":"https://orcid.org/0000-0002-0517-120X","observed_orcids":["https://orcid.org/0000-0002-0517-120X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick S. Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017753241","display_name":"Christopher R. Smith","orcid":"https://orcid.org/0000-0003-2795-0922","observed_orcids":["https://orcid.org/0000-0003-2795-0922"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher R. Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007700384","display_name":"Pierre\u2010Yves Bounaud","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre-Yves Bounaud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043173903","display_name":"Katti Jessen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katti A. Jessen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090775995","display_name":"Crystal M. Tang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Crystal M. Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016891210","display_name":"Nanni H. Huser","orcid":"https://orcid.org/0009-0005-8709-0903","observed_orcids":["https://orcid.org/0009-0005-8709-0903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nanni H. Huser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035026356","display_name":"Jeremy D. Felce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy D. Felce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055907829","display_name":"Karen Froning","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen J. Froning","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024788247","display_name":"Marshall C. Peterman","orcid":"https://orcid.org/0009-0009-2739-2239","observed_orcids":["https://orcid.org/0009-0009-2739-2239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marshall C. Peterman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028075560","display_name":"Brandon E. Aubol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brandon E. Aubol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015632679","display_name":"Steve F. Gessert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve F. Gessert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014074389","display_name":"J.M. Sauder","orcid":"https://orcid.org/0000-0002-0254-4955","observed_orcids":["https://orcid.org/0000-0002-0254-4955"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Michael Sauder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038886245","display_name":"Kenneth D. Schwinn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth D. Schwinn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086041232","display_name":"Marijane Russell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marijane Russell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000291728","display_name":"Isabelle Anne Rooney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabelle A. Rooney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jason Adams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason Adams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058284518","display_name":"Barbara C. Leon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara C. Leon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062547671","display_name":"Tuan H. Do","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tuan H. Do","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030750442","display_name":"Jeff Blaney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeff M. Blaney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015619526","display_name":"Paul A. Sprengeler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul A. Sprengeler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105361201","display_name":"Devon A. Thompson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Devon A. Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088863132","display_name":"Lydia Smyth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lydia Smyth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071351267","display_name":"Laura A. Pelletier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura A. Pelletier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020683463","display_name":"S. Atwell","orcid":"https://orcid.org/0000-0002-2578-2462","observed_orcids":["https://orcid.org/0000-0002-2578-2462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shane Atwell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078504875","display_name":"Kevin R. Holme","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Holme","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108615827","display_name":"Stephen R. Wasserman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen R. Wasserman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084563908","display_name":"Spencer Emtage","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Spencer Emtage","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068648875","display_name":"Stephen Kevin Burley","orcid":"https://orcid.org/0000-0002-2487-9713","observed_orcids":["https://orcid.org/0000-0002-2487-9713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen K. Burley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058385152","display_name":"Siegfried Reich","orcid":"https://orcid.org/0000-0002-6840-2618","observed_orcids":["https://orcid.org/0000-0002-6840-2618"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Siegfried H. Reich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.06469999998807907,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/met-receptor-tyrosine-kinase","display_name":"MET receptor tyrosine kinase","score":0.8740000128746033},{"id":"https://openalex.org/keywords/atp-competitive-inhibitors","display_name":"ATP-competitive inhibitors","score":0.9240000247955322},{"id":"https://openalex.org/keywords/kinase-inhibitor-selectivity","display_name":"kinase selectivity","score":0.8700000047683716},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/in-vivo-tumor-model","display_name":"in vivo tumor model","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7514240741729736},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.6558258533477783},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5754265785217285},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.5650181770324707},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.478153795003891},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4648420214653015},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41735196113586426},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39604148268699646},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3768587112426758},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3430996537208557},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3308538794517517},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.08258619904518127},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08062127232551575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.052688777446746826}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.22485138","doi":"https://doi.org/10.1158/1535-7163.22485138","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22485138","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22485138.v1","doi":"https://doi.org/10.1158/1535-7163.22485138.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22485138.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39936687","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22485138","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Tables_1-3_Figures_1-4_from_SGX523_is_an_exquisitely_selective_ATP-competitive_inhibitor_of_the_MET_receptor_tyrosine_kinase_with_antitumor_activity_i_in_vivo_i_/22485138","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22485138","doi":"https://doi.org/10.1158/1535-7163.22485138","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22485138","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361891345.pdf","grobid_xml":"https://content.openalex.org/works/W4361891345.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2120460652","https://openalex.org/W4361953965","https://openalex.org/W2262590203","https://openalex.org/W2280336592","https://openalex.org/W4236689035","https://openalex.org/W1967107350","https://openalex.org/W2239552271","https://openalex.org/W2017193770","https://openalex.org/W2161604270","https://openalex.org/W2165588904"],"abstract_inverted_index":{"Supplementary":[0],"Tables":[1],"1-3,":[2],"Figures":[3],"1-4":[4],"from":[5],"SGX523":[6],"is":[7],"an":[8],"exquisitely":[9],"selective,":[10],"ATP-competitive":[11],"inhibitor":[12],"of":[13],"the":[14],"MET":[15],"receptor":[16],"tyrosine":[17],"kinase":[18],"with":[19],"antitumor":[20],"activity":[21],"in":[22],"vivo":[23]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}