{"id":"https://openalex.org/W4361891007","doi":"https://doi.org/10.1158/1078-0432.22484433","title":"Figure_S4 from Phase Ib Dose Expansion and Translational Analyses of Olaparib in Combination with Capivasertib in Recurrent Endometrial, Triple-Negative Breast, and Ovarian Cancer","display_name":"Figure_S4 from Phase Ib Dose Expansion and Translational Analyses of Olaparib in Combination with Capivasertib in Recurrent Endometrial, Triple-Negative Breast, and Ovarian Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361891007","doi":"https://doi.org/10.1158/1078-0432.22484433"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22484433","doi":"https://doi.org/10.1158/1078-0432.22484433","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22484433","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22484433","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026269100","display_name":"Shannon Neville Westin","orcid":"https://orcid.org/0000-0002-1922-0156","observed_orcids":["https://orcid.org/0000-0002-1922-0156"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shannon N. Westin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1922-0156","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047361129","display_name":"Marilyne Labrie","orcid":"https://orcid.org/0000-0003-3957-5533","observed_orcids":["https://orcid.org/0000-0003-3957-5533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marilyne Labrie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014713051","display_name":"Jennifer Keating Litton","orcid":"https://orcid.org/0000-0001-8390-4985","observed_orcids":["https://orcid.org/0000-0001-8390-4985"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer K. Litton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026225429","display_name":"Aurora Blucher","orcid":"https://orcid.org/0000-0001-6460-010X","observed_orcids":["https://orcid.org/0000-0001-6460-010X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aurora Blucher","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6460-010X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606638","display_name":"Yong Fang","orcid":"https://orcid.org/0000-0002-9774-5572","observed_orcids":["https://orcid.org/0000-0002-9774-5572"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Fang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012829421","display_name":"Christopher P. Vellano","orcid":"https://orcid.org/0000-0002-6643-0818","observed_orcids":["https://orcid.org/0000-0002-6643-0818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher P. Vellano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048521277","display_name":"Joseph R. Marszalek","orcid":"https://orcid.org/0000-0003-2320-3209","observed_orcids":["https://orcid.org/0000-0003-2320-3209"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph R. Marszalek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071445059","display_name":"Ningping Feng","orcid":"https://orcid.org/0000-0003-1917-9648","observed_orcids":["https://orcid.org/0000-0003-1917-9648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ningping Feng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1917-9648","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021529302","display_name":"Xiaoyan Ma","orcid":"https://orcid.org/0000-0002-6487-0887","observed_orcids":["https://orcid.org/0000-0002-6487-0887"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"XiaoYan Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000280486","display_name":"Allison Creason","orcid":"https://orcid.org/0000-0001-5724-1276","observed_orcids":["https://orcid.org/0000-0001-5724-1276"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allison Creason","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5724-1276","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080656521","display_name":"Bryan M. Fellman","orcid":"https://orcid.org/0000-0002-1810-5762","observed_orcids":["https://orcid.org/0000-0002-1810-5762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bryan Fellman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040527192","display_name":"Ying Yuan","orcid":"https://orcid.org/0000-0002-3922-9553","observed_orcids":["https://orcid.org/0000-0002-3922-9553"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Yuan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320215","display_name":"Sanghoon Lee","orcid":"https://orcid.org/0000-0003-2173-6490","observed_orcids":["https://orcid.org/0000-0003-2173-6490"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanghoon Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089310357","display_name":"Tae\u2010Beom Kim","orcid":"https://orcid.org/0000-0002-4970-3343","observed_orcids":["https://orcid.org/0000-0002-4970-3343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tae-Beom Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119011526","display_name":"Jinsong Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinsong Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001850756","display_name":"Anca Chelariu-Raicu","orcid":"https://orcid.org/0000-0003-2944-9488","observed_orcids":["https://orcid.org/0000-0003-2944-9488"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anca Chelariu-Raicu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2944-9488","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967148","display_name":"Tsun Hsuan Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsun Hsuan Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967059","display_name":"Nashwa N. Kabil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nashwa Kabil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045683633","display_name":"Pamela T. Soliman","orcid":"https://orcid.org/0000-0002-8784-9212","observed_orcids":["https://orcid.org/0000-0002-8784-9212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pamela T. Soliman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082358197","display_name":"Michael Frumovitz","orcid":"https://orcid.org/0000-0002-0810-2648","observed_orcids":["https://orcid.org/0000-0002-0810-2648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Frumovitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967199","display_name":"Katheleen M. Schmeler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katheleen M. Schmeler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000158770","display_name":"Amir Anthony Jazaeri","orcid":"https://orcid.org/0000-0003-4335-4151","observed_orcids":["https://orcid.org/0000-0003-4335-4151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amir Jazaeri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4335-4151","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078692182","display_name":"Karen H. Lu","orcid":"https://orcid.org/0000-0002-5317-9927","observed_orcids":["https://orcid.org/0000-0002-5317-9927"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen H. Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027764647","display_name":"Rashmi Krishna Murthy","orcid":"https://orcid.org/0000-0002-0103-4718","observed_orcids":["https://orcid.org/0000-0002-0103-4718"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rashmi Murthy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0103-4718","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000098403","display_name":"Larissa Alejandra Meyer","orcid":"https://orcid.org/0000-0002-2687-7463","observed_orcids":["https://orcid.org/0000-0002-2687-7463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larissa A. Meyer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2687-7463","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088938634","display_name":"Charlotte C. Sun","orcid":"https://orcid.org/0000-0003-0850-7853","observed_orcids":["https://orcid.org/0000-0003-0850-7853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charlotte C. Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100640276","display_name":"Anil K. Sood","orcid":"https://orcid.org/0000-0002-5415-9901","observed_orcids":["https://orcid.org/0000-0002-5415-9901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anil K. Sood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009234043","display_name":"Robert Louis Coleman","orcid":"https://orcid.org/0000-0001-9343-8754","observed_orcids":["https://orcid.org/0000-0001-9343-8754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert L. Coleman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9343-8754","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0144-9614","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":1.0},{"id":"https://openalex.org/keywords/capivasertib","display_name":"capivasertib","score":1.0},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.8140000104904175},{"id":"https://openalex.org/keywords/parp-inhibitor-resistance","display_name":"PARP inhibitor resistance","score":0.6129999756813049},{"id":"https://openalex.org/keywords/recurrent-endometrial-cancer","display_name":"recurrent endometrial cancer","score":0.8740000128746033},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/recurrent-ovarian-cancer","display_name":"recurrent ovarian cancer","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.7584761381149292},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.599961519241333},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.5892146229743958},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4998760223388672},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4891710579395294},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.4764992594718933},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.45074209570884705},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.423892080783844},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4137662947177887},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23538583517074585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22704780101776123},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08079048991203308},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07881245017051697},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.05363461375236511},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22484433","doi":"https://doi.org/10.1158/1078-0432.22484433","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22484433","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22484433","doi":"https://doi.org/10.1158/1078-0432.22484433","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22484433","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.44999998807907104}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361281158","https://openalex.org/W2944461583","https://openalex.org/W4389948617","https://openalex.org/W2792971967","https://openalex.org/W3112954044","https://openalex.org/W2938482998","https://openalex.org/W3198165388","https://openalex.org/W2976982111","https://openalex.org/W1963619902","https://openalex.org/W1618306469"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"S4":[2]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}