{"id":"https://openalex.org/W4361890409","doi":"https://doi.org/10.1158/1078-0432.22480662","title":"Table S4 from LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors","display_name":"Table S4 from LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361890409","doi":"https://doi.org/10.1158/1078-0432.22480662"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22480662","doi":"https://doi.org/10.1158/1078-0432.22480662","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22480662","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22480662","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081446127","display_name":"Kelli\u2010Ann Monaco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelli-Ann Monaco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016326595","display_name":"Scott M. Delach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Delach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082434173","display_name":"Jing Yuan","orcid":"https://orcid.org/0000-0001-9050-4496","observed_orcids":["https://orcid.org/0000-0001-9050-4496"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Yuan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059882947","display_name":"Yuji M. Mishina","orcid":"https://orcid.org/0000-0002-6268-4204","observed_orcids":["https://orcid.org/0000-0002-6268-4204"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuji Mishina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027266676","display_name":"Paul Fordjour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Fordjour","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051948810","display_name":"Emma Labrot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma Labrot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel McKay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel McKay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067030899","display_name":"Ribo Guo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ribo Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009764729","display_name":"Stacy E. Higgins","orcid":"https://orcid.org/0009-0005-3388-8389","observed_orcids":["https://orcid.org/0009-0005-3388-8389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stacy Higgins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073935082","display_name":"Hui Qin Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Qin Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045823","display_name":"Jinsheng Liang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinsheng Liang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076260245","display_name":"Karen Bui","orcid":"https://orcid.org/0000-0001-7582-853X","observed_orcids":["https://orcid.org/0000-0001-7582-853X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen Bui","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7582-853X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103523060","display_name":"John Green","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Green","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001268477","display_name":"Peter Aspesi","orcid":"https://orcid.org/0000-0002-1987-6446","observed_orcids":["https://orcid.org/0000-0002-1987-6446"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Aspesi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1987-6446","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109352399","display_name":"Jessi Ambrose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessi Ambrose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043061117","display_name":"Felipa Mapa","orcid":"https://orcid.org/0000-0002-9985-4545","observed_orcids":["https://orcid.org/0000-0002-9985-4545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Felipa Mapa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9985-4545","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021784750","display_name":"Lesley A. Mathews Griner","orcid":"https://orcid.org/0000-0001-9847-1107","observed_orcids":["https://orcid.org/0000-0001-9847-1107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lesley Griner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088929965","display_name":"Mariela Jaskelioff","orcid":"https://orcid.org/0000-0002-5415-6401","observed_orcids":["https://orcid.org/0000-0002-5415-6401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariela Jaskelioff","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5415-6401","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"John Fuller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Fuller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112741330","display_name":"Kenneth C. Crawford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth Crawford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038286208","display_name":"Gwynn Pardee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gwynn Pardee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088742105","display_name":"Stephania Widger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephania Widger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004171995","display_name":"Peter S. Hammerman","orcid":"https://orcid.org/0009-0006-9143-899X","observed_orcids":["https://orcid.org/0009-0006-9143-899X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter S. Hammerman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040093136","display_name":"Jeffrey A. Engelman","orcid":"https://orcid.org/0009-0004-0775-4523","observed_orcids":["https://orcid.org/0009-0004-0775-4523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey A. Engelman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049772515","display_name":"Darrin D. Stuart","orcid":"https://orcid.org/0000-0002-4666-4000","observed_orcids":["https://orcid.org/0000-0002-4666-4000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darrin D. Stuart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074912070","display_name":"Vesselina G. Cooke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vesselina G. Cooke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025118565","display_name":"Giordano Caponigro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giordano Caponigro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/braf-inhibitors","display_name":"BRAF inhibitors","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cell-line-sensitivity","display_name":"cell line sensitivity","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6515393257141113},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5366828441619873},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.5040110945701599},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4846516251564026},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43342331051826477},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4261242747306824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41337841749191284},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36471986770629883},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3588235676288605},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3246975839138031},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21029600501060486},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.182030588388443},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15704402327537537},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1505095660686493},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22480662","doi":"https://doi.org/10.1158/1078-0432.22480662","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22480662","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22480662","doi":"https://doi.org/10.1158/1078-0432.22480662","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22480662","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361890406","https://openalex.org/W4361890218","https://openalex.org/W4361890228","https://openalex.org/W4361939300","https://openalex.org/W4361890296","https://openalex.org/W4361939377","https://openalex.org/W4361939247","https://openalex.org/W4361890299","https://openalex.org/W4361939264","https://openalex.org/W4361890326"],"abstract_inverted_index":{"Proliferation":[0],"IC50":[1],"values":[2],"for":[3],"various":[4],"cell":[5,8],"lines":[6],"and":[7],"line":[9],"derivatives":[10]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-04-05T00:00:00"}