{"id":"https://openalex.org/W4361889583","doi":"https://doi.org/10.1158/1078-0432.22479353","title":"Table S5 from Genomic Analysis of Circulating Tumor DNA in 3,334 Patients with Advanced Prostate Cancer Identifies Targetable BRCA Alterations and AR Resistance Mechanisms","display_name":"Table S5 from Genomic Analysis of Circulating Tumor DNA in 3,334 Patients with Advanced Prostate Cancer Identifies Targetable BRCA Alterations and AR Resistance Mechanisms","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361889583","doi":"https://doi.org/10.1158/1078-0432.22479353"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22479353","doi":"https://doi.org/10.1158/1078-0432.22479353","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22479353","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22479353","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027336186","display_name":"Hanna Tukachinsky","orcid":"https://orcid.org/0000-0002-0777-7555","observed_orcids":["https://orcid.org/0000-0002-0777-7555"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanna Tukachinsky","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0777-7555","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032009066","display_name":"Russell William Madison","orcid":"https://orcid.org/0000-0002-7838-2526","observed_orcids":["https://orcid.org/0000-0002-7838-2526"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Russell W. Madison","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7838-2526","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078798686","display_name":"Jon Chung","orcid":"https://orcid.org/0000-0003-0526-3670","observed_orcids":["https://orcid.org/0000-0003-0526-3670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jon H. Chung","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0526-3670","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061790056","display_name":"Ole V. Gjoerup","orcid":"https://orcid.org/0000-0001-9127-8769","observed_orcids":["https://orcid.org/0000-0001-9127-8769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ole V. Gjoerup","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026556414","display_name":"Eric Allan Severson","orcid":"https://orcid.org/0000-0003-4394-2412","observed_orcids":["https://orcid.org/0000-0003-4394-2412"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric A. Severson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071168587","display_name":"Lucas M. Dennis","orcid":"https://orcid.org/0000-0002-5299-8066","observed_orcids":["https://orcid.org/0000-0002-5299-8066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucas Dennis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042945519","display_name":"Bernard J. Fendler","orcid":"https://orcid.org/0000-0001-7352-0689","observed_orcids":["https://orcid.org/0000-0001-7352-0689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard J. Fendler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089794644","display_name":"Samantha Morley","orcid":"https://orcid.org/0009-0007-4507-3739","observed_orcids":["https://orcid.org/0009-0007-4507-3739"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samantha Morley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101886633","display_name":"Lei Zhong","orcid":"https://orcid.org/0000-0002-0208-1823","observed_orcids":["https://orcid.org/0000-0002-0208-1823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Zhong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025819053","display_name":"Ryon P. Graf","orcid":"https://orcid.org/0000-0002-8065-4148","observed_orcids":["https://orcid.org/0000-0002-8065-4148"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryon P. Graf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088559019","display_name":"Jeffrey S. Ross","orcid":"https://orcid.org/0000-0001-8494-2596","observed_orcids":["https://orcid.org/0000-0001-8494-2596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey S. Ross","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8494-2596","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047888321","display_name":"Brian Michael Alexander","orcid":"https://orcid.org/0000-0003-3903-9175","observed_orcids":["https://orcid.org/0000-0003-3903-9175"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian M. Alexander","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3903-9175","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062426672","display_name":"Wassim M. Abida","orcid":"https://orcid.org/0000-0002-9006-7043","observed_orcids":["https://orcid.org/0000-0002-9006-7043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wassim Abida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110735930","display_name":"Simon Chowdhury","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Chowdhury","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012804612","display_name":"Charles J. Ryan","orcid":"https://orcid.org/0000-0002-2081-3557","observed_orcids":["https://orcid.org/0000-0002-2081-3557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles J. Ryan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007779528","display_name":"Karim S. Fizazi","orcid":"https://orcid.org/0000-0002-6068-9474","observed_orcids":["https://orcid.org/0000-0002-6068-9474"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karim Fizazi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023257867","display_name":"Tony Golsorkhi","orcid":"https://orcid.org/0000-0002-9146-6230","observed_orcids":["https://orcid.org/0000-0002-9146-6230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tony Golsorkhi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9146-6230","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078054913","display_name":"Simon Paul Watkins","orcid":"https://orcid.org/0000-0001-8628-8399","observed_orcids":["https://orcid.org/0000-0001-8628-8399"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon P. Watkins","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8628-8399","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103133276","display_name":"Andrew D. Simmons","orcid":"https://orcid.org/0000-0001-6075-0549","observed_orcids":["https://orcid.org/0000-0001-6075-0549"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Simmons","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6075-0549","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040200708","display_name":"Andrea Loehr","orcid":"https://orcid.org/0009-0008-6682-8405","observed_orcids":["https://orcid.org/0009-0008-6682-8405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Loehr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001623694","display_name":"Jeffrey Michael Venstrom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey M. Venstrom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045665778","display_name":"Geoffrey R. Oxnard","orcid":"https://orcid.org/0000-0003-1054-8240","observed_orcids":["https://orcid.org/0000-0003-1054-8240"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoffrey R. Oxnard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8291000127792358,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8291000127792358,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.1370999962091446,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.8980000019073486},{"id":"https://openalex.org/keywords/advanced-prostate-cancer","display_name":"advanced prostate cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":1.0},{"id":"https://openalex.org/keywords/deleterious-mutations","display_name":"deleterious mutations","score":0.9490000009536743},{"id":"https://openalex.org/keywords/reversion-mutations","display_name":"reversion mutations","score":0.9700000286102295},{"id":"https://openalex.org/keywords/androgen-receptor-resistance","display_name":"androgen receptor resistance","score":0.8939999938011169},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5490000247955322},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C70883133","wikidata":"https://www.wikidata.org/wiki/Q7318316","display_name":"Reversion","level":4,"score":0.7722992897033691},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6885628700256348},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5199590921401978},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.44575995206832886},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41962334513664246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40045326948165894},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3705863356590271},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35352781414985657},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34615829586982727},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17955738306045532},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.06169074773788452}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.22479353","doi":"https://doi.org/10.1158/1078-0432.22479353","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22479353","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22479353.v1","doi":"https://doi.org/10.1158/1078-0432.22479353.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22479353.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22479353","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Table_S5_from_Genomic_Analysis_of_Circulating_Tumor_DNA_in_3_334_Patients_with_Advanced_Prostate_Cancer_Identifies_Targetable_BRCA_Alterations_and_AR_Resistance_Mechanisms/22479353","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22479353","doi":"https://doi.org/10.1158/1078-0432.22479353","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22479353","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361938787","https://openalex.org/W4361938864","https://openalex.org/W4361938982","https://openalex.org/W4361938753","https://openalex.org/W4361889651","https://openalex.org/W4361889743","https://openalex.org/W4361889745","https://openalex.org/W4361938889","https://openalex.org/W4361938827","https://openalex.org/W4361938771"],"abstract_inverted_index":{"List":[0],"of":[1],"BRCA1/2":[2],"deleterious":[3],"(red)":[4],"and":[5],"reversion":[6],"(blue)":[7],"mutations":[8],"summarized":[9],"in":[10],"Fig":[11],"3C.":[12]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}