{"id":"https://openalex.org/W4361889455","doi":"https://doi.org/10.1158/1078-0432.22478667","title":"Supplementary Data from Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer: Analysis From the Phase II TRITON2 Study","display_name":"Supplementary Data from Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer: Analysis From the Phase II TRITON2 Study","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361889455","doi":"https://doi.org/10.1158/1078-0432.22478667"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22478667","doi":"https://doi.org/10.1158/1078-0432.22478667","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22478667","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22478667","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062426672","display_name":"Wassim M. Abida","orcid":"https://orcid.org/0000-0002-9006-7043","observed_orcids":["https://orcid.org/0000-0002-9006-7043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wassim Abida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"David Campbell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Campbell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068014441","display_name":"Akash Patnaik","orcid":"https://orcid.org/0000-0001-5306-0208","observed_orcids":["https://orcid.org/0000-0001-5306-0208"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akash Patnaik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086640363","display_name":"Jeremy David Shapiro","orcid":"https://orcid.org/0009-0007-9290-8145","observed_orcids":["https://orcid.org/0009-0007-9290-8145"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy D. Shapiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076200732","display_name":"Brieuc R. Sautois","orcid":"https://orcid.org/0000-0002-0029-7735","observed_orcids":["https://orcid.org/0000-0002-0029-7735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brieuc Sautois","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059219836","display_name":"Nicholas J. Vogelzang","orcid":"https://orcid.org/0000-0002-7665-6079","observed_orcids":["https://orcid.org/0000-0002-7665-6079"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas J. Vogelzang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7665-6079","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006671522","display_name":"\u00c9ric Voog","orcid":"https://orcid.org/0000-0001-8366-8003","observed_orcids":["https://orcid.org/0000-0001-8366-8003"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric G. Voog","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030233600","display_name":"Alan Haruo Bryce","orcid":"https://orcid.org/0000-0002-0206-3895","observed_orcids":["https://orcid.org/0000-0002-0206-3895"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan H. Bryce","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0206-3895","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006249276","display_name":"Ray McDermott","orcid":"https://orcid.org/0000-0002-8952-4315","observed_orcids":["https://orcid.org/0000-0002-8952-4315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ray McDermott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018935401","display_name":"Francesco Ricci","orcid":"https://orcid.org/0000-0003-4941-8646","observed_orcids":["https://orcid.org/0000-0003-4941-8646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Ricci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067789137","display_name":"Julie Haewon Rowe","orcid":"https://orcid.org/0000-0001-7583-7794","observed_orcids":["https://orcid.org/0000-0001-7583-7794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Rowe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083315480","display_name":"Jingsong Zhang","orcid":"https://orcid.org/0000-0003-1192-5116","observed_orcids":["https://orcid.org/0000-0003-1192-5116"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingsong Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019869973","display_name":"Josep Maria Piulats","orcid":"https://orcid.org/0000-0002-3606-1724","observed_orcids":["https://orcid.org/0000-0002-3606-1724"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josep Maria Piulats","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007779528","display_name":"Karim S. Fizazi","orcid":"https://orcid.org/0000-0002-6068-9474","observed_orcids":["https://orcid.org/0000-0002-6068-9474"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karim Fizazi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016971686","display_name":"Axel S. Merseburger","orcid":"https://orcid.org/0000-0001-6467-3931","observed_orcids":["https://orcid.org/0000-0001-6467-3931"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Axel S. Merseburger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001591556","display_name":"Celestia S. Higano","orcid":"https://orcid.org/0000-0001-5308-8972","observed_orcids":["https://orcid.org/0000-0001-5308-8972"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Celestia S. Higano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103019012","display_name":"Laurence Eliot Miles Krieger","orcid":"https://orcid.org/0000-0002-6894-6041","observed_orcids":["https://orcid.org/0000-0002-6894-6041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurence E. Krieger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012804612","display_name":"Charles J. Ryan","orcid":"https://orcid.org/0000-0002-2081-3557","observed_orcids":["https://orcid.org/0000-0002-2081-3557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles J. Ryan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020006331","display_name":"Felix Yi-Chung Feng","orcid":"https://orcid.org/0000-0002-0963-7687","observed_orcids":["https://orcid.org/0000-0002-0963-7687","https://orcid.org/0000-0001-9756-4037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Felix Y. Feng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103133276","display_name":"Andrew D. Simmons","orcid":"https://orcid.org/0000-0001-6075-0549","observed_orcids":["https://orcid.org/0000-0001-6075-0549"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew D. Simmons","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6075-0549","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040200708","display_name":"Andrea Loehr","orcid":"https://orcid.org/0009-0008-6682-8405","observed_orcids":["https://orcid.org/0009-0008-6682-8405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Loehr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071843782","display_name":"Darrin Despain","orcid":"https://orcid.org/0000-0002-9445-8834","observed_orcids":["https://orcid.org/0000-0002-9445-8834"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darrin Despain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904665","display_name":"Melanie Dowson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melanie Dowson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Foad Green","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Foad Green","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078054913","display_name":"Simon Paul Watkins","orcid":"https://orcid.org/0000-0001-8628-8399","observed_orcids":["https://orcid.org/0000-0001-8628-8399"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon P. Watkins","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8628-8399","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023257867","display_name":"Tony Golsorkhi","orcid":"https://orcid.org/0000-0002-9146-6230","observed_orcids":["https://orcid.org/0000-0002-9146-6230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tony Golsorkhi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9146-6230","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110735930","display_name":"Simon Chowdhury","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Chowdhury","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.6800000071525574},{"id":"https://openalex.org/keywords/rucaparib","display_name":"rucaparib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.8159412145614624},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7459225654602051},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.7242376208305359},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5847111940383911},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5149210691452026},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5096044540405273},{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.4615052044391632},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42996853590011597},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4218288064002991},{"id":"https://openalex.org/C2909513124","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA Damage Repair","level":4,"score":0.4138176441192627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3814992308616638},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3790012300014496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26306307315826416},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23297840356826782},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.07334494590759277}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22478667","doi":"https://doi.org/10.1158/1078-0432.22478667","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22478667","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22478667","doi":"https://doi.org/10.1158/1078-0432.22478667","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22478667","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361889522","https://openalex.org/W4361889518","https://openalex.org/W4361889579","https://openalex.org/W4361889633","https://openalex.org/W3008060424","https://openalex.org/W4361889441","https://openalex.org/W4361947252","https://openalex.org/W4379203214","https://openalex.org/W2978095728","https://openalex.org/W3006907257"],"abstract_inverted_index":{"Suppl":[0],"Fig":[1],"Legends":[2]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-04-05T00:00:00"}