{"id":"https://openalex.org/W4361886579","doi":"https://doi.org/10.1158/1078-0432.22466786","title":"Supplemental Figure 5B from Exposure\u2013Response Analysis of Alvocidib (Flavopiridol) Treatment by Bolus or Hybrid Administration in Newly Diagnosed or Relapsed/Refractory Acute Leukemia Patients","display_name":"Supplemental Figure 5B from Exposure\u2013Response Analysis of Alvocidib (Flavopiridol) Treatment by Bolus or Hybrid Administration in Newly Diagnosed or Relapsed/Refractory Acute Leukemia Patients","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361886579","doi":"https://doi.org/10.1158/1078-0432.22466786"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22466786","doi":"https://doi.org/10.1158/1078-0432.22466786","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22466786","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22466786","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004471390","display_name":"Carl LaCerte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl LaCerte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000044132","display_name":"Vijay D. Ivaturi","orcid":"https://orcid.org/0000-0002-6433-1154","observed_orcids":["https://orcid.org/0000-0002-6433-1154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vijay Ivaturi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083885025","display_name":"Jogarao V. S. Gobburu","orcid":"https://orcid.org/0000-0002-8348-4295","observed_orcids":["https://orcid.org/0000-0002-8348-4295"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joga Gobburu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079274832","display_name":"Jacqueline M. Greer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacqueline M. Greer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041531063","display_name":"L. Austin Doyle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Austin Doyle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"John J. Wright","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John J. Wright","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040758762","display_name":"Judith E. Karp","orcid":"https://orcid.org/0000-0003-4754-127X","observed_orcids":["https://orcid.org/0000-0003-4754-127X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judith E. Karp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015341987","display_name":"Michelle A. Rudek","orcid":"https://orcid.org/0000-0001-5739-6868","observed_orcids":["https://orcid.org/0000-0001-5739-6868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle A. Rudek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.4269999861717224,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.4269999861717224,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.36570000648498535,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.06199999898672104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavopiridol","display_name":"flavopiridol","score":1.0},{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":0.8149999976158142},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8809999823570251},{"id":"https://openalex.org/keywords/bolus-dose","display_name":"bolus dosing","score":0.8659999966621399},{"id":"https://openalex.org/keywords/unbound-drug-concentration","display_name":"unbound drug concentration","score":0.7599999904632568},{"id":"https://openalex.org/keywords/exposure-response-relationship","display_name":"exposure-response relationship","score":0.5509999990463257},{"id":"https://openalex.org/keywords/relapsed-refractory-leukemia","display_name":"relapsed/refractory leukemia","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.7115870714187622},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6763268113136292},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6070283651351929},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6068252325057983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.548554003238678},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42445603013038635},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41155609488487244},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4080694317817688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08895793557167053},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22466786","doi":"https://doi.org/10.1158/1078-0432.22466786","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22466786","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22466786","doi":"https://doi.org/10.1158/1078-0432.22466786","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22466786","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2586989097","https://openalex.org/W4361946561","https://openalex.org/W1989819905","https://openalex.org/W2072874976","https://openalex.org/W2527377099","https://openalex.org/W2550700223","https://openalex.org/W1990453662","https://openalex.org/W2571041746","https://openalex.org/W2953096157","https://openalex.org/W2052120331"],"abstract_inverted_index":{"Representative":[0],"Individual":[1],"Concentration":[2],"versus":[3],"Time":[4],"Pharmacokinetic":[5],"Profiles":[6],"for":[7],"Total":[8],"or":[9,15],"Unbound":[10],"Flavopiridol":[11],"Using":[12],"Bolus":[13],"(A)":[14],"Hybrid":[16],"(B)":[17],"Dosing":[18],"Schemes.":[19]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-04-05T00:00:00"}