{"id":"https://openalex.org/W4361884532","doi":"https://doi.org/10.1158/1078-0432.22458780","title":"Supplementary Table S1 and Figure Legends from Personalized Preclinical Trials in BRAF Inhibitor\u2013Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies","display_name":"Supplementary Table S1 and Figure Legends from Personalized Preclinical Trials in BRAF Inhibitor\u2013Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361884532","doi":"https://doi.org/10.1158/1078-0432.22458780"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22458780","doi":"https://doi.org/10.1158/1078-0432.22458780","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22458780","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.22458780","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037620517","display_name":"Clemens Krepler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clemens Krepler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067382998","display_name":"Min Xiao","orcid":"https://orcid.org/0000-0001-9421-6344","observed_orcids":["https://orcid.org/0000-0001-9421-6344"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Xiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058997105","display_name":"Katrin Sproesser","orcid":"https://orcid.org/0009-0000-5043-6281","observed_orcids":["https://orcid.org/0009-0000-5043-6281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katrin Sproesser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051118651","display_name":"Patricia A. Brafford","orcid":"https://orcid.org/0000-0002-4836-7421","observed_orcids":["https://orcid.org/0000-0002-4836-7421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia A. Brafford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022769141","display_name":"Batool Shannan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Batool Shannan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065799733","display_name":"Marilda Beqiri","orcid":"https://orcid.org/0000-0002-9738-0243","observed_orcids":["https://orcid.org/0000-0002-9738-0243"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marilda Beqiri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432490","display_name":"Qin Liu","orcid":"https://orcid.org/0000-0001-9964-580X","observed_orcids":["https://orcid.org/0000-0001-9964-580X","https://orcid.org/0009-0000-3931-0813"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qin Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407852","display_name":"Wei Xu","orcid":"https://orcid.org/0000-0002-1960-0992","observed_orcids":["https://orcid.org/0000-0002-1960-0992","https://orcid.org/0000-0002-9590-1906","https://orcid.org/0009-0009-8295-9963","https://orcid.org/0000-0003-4208-7477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044963819","display_name":"Bradley Garman","orcid":"https://orcid.org/0000-0001-9641-4125","observed_orcids":["https://orcid.org/0000-0001-9641-4125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bradley Garman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072490052","display_name":"Katherine L. Nathanson","orcid":"https://orcid.org/0000-0002-6740-0901","observed_orcids":["https://orcid.org/0000-0002-6740-0901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine L. Nathanson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110634","display_name":"Xiaowei Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaowei Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035929126","display_name":"Giorgos Constantine Karakousis","orcid":"https://orcid.org/0000-0002-9321-2795","observed_orcids":["https://orcid.org/0000-0002-9321-2795"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgos C. Karakousis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020581776","display_name":"Yiling Lu","orcid":"https://orcid.org/0000-0002-3662-2106","observed_orcids":["https://orcid.org/0000-0002-3662-2106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yiling Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011684568","display_name":"Tamer A. Ahmed","orcid":"https://orcid.org/0000-0002-6922-6193","observed_orcids":["https://orcid.org/0000-0002-6922-6193"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamer A. Ahmed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078118619","display_name":"Poulikos I. Poulikakos","orcid":"https://orcid.org/0000-0001-6071-9963","observed_orcids":["https://orcid.org/0000-0001-6071-9963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Poulikos I. Poulikakos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025118565","display_name":"Giordano Caponigro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giordano Caponigro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065761868","display_name":"Markus Boehm","orcid":"https://orcid.org/0000-0002-7025-3287","observed_orcids":["https://orcid.org/0000-0002-7025-3287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus Boehm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Malte Peters","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malte Peters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012671311","display_name":"Lynn Mara Schuchter","orcid":"https://orcid.org/0000-0002-0523-4346","observed_orcids":["https://orcid.org/0000-0002-0523-4346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lynn M. Schuchter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085589424","display_name":"Ashani T. Weeraratna","orcid":"https://orcid.org/0000-0003-0448-6952","observed_orcids":["https://orcid.org/0000-0003-0448-6952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashani T. Weeraratna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028792712","display_name":"Meenhard Herlyn","orcid":"https://orcid.org/0000-0003-0839-0739","observed_orcids":["https://orcid.org/0000-0003-0839-0739"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meenhard Herlyn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/braf-inhibitor-resistance","display_name":"BRAF inhibitor resistance","score":0.8220000267028809},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8769999742507935},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9620000123977661},{"id":"https://openalex.org/keywords/clinical-follow-up","display_name":"clinical follow-up","score":0.8640000224113464}],"concepts":[{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.5772891640663147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5457127094268799},{"id":"https://openalex.org/C3019258254","wikidata":"https://www.wikidata.org/wiki/Q1423317","display_name":"Second line","level":3,"score":0.45289745926856995},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4175226390361786},{"id":"https://openalex.org/C2993493390","wikidata":"https://www.wikidata.org/wiki/Q5453208","display_name":"First line","level":2,"score":0.4126170873641968},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4068619906902313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37878063321113586},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12461236119270325},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.07890412211418152}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22458780","doi":"https://doi.org/10.1158/1078-0432.22458780","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22458780","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22458780","doi":"https://doi.org/10.1158/1078-0432.22458780","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22458780","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2565605759","https://openalex.org/W4362404242","https://openalex.org/W4361951697","https://openalex.org/W2207662183","https://openalex.org/W7099819376","https://openalex.org/W4362550717"],"abstract_inverted_index":{"Supplementary":[0],"Table":[1],"S1:":[2],"Summary":[3],"of":[4],"melanoma":[5],"patients":[6],"with":[7],"clinical":[8],"follow-up.":[9],"Figure":[10],"Legends":[11]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-04-05T00:00:00"}