{"id":"https://openalex.org/W4361884459","doi":"https://doi.org/10.1158/1078-0432.22457546","title":"Supplementary Figure 2 from Sorafenib Inhibition of Mcl-1 Accelerates ATRA-Induced Apoptosis in Differentiation-Responsive AML Cells","display_name":"Supplementary Figure 2 from Sorafenib Inhibition of Mcl-1 Accelerates ATRA-Induced Apoptosis in Differentiation-Responsive AML Cells","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361884459","doi":"https://doi.org/10.1158/1078-0432.22457546"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22457546","doi":"https://doi.org/10.1158/1078-0432.22457546","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22457546","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22457546","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100431254","display_name":"Rui Wang","orcid":"https://orcid.org/0000-0002-4719-9921","observed_orcids":["https://orcid.org/0000-0002-4719-9921","https://orcid.org/0009-0003-7191-7828"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102508198","display_name":"Lijuan Xia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lijuan Xia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062295987","display_name":"Janice Lynn Gabrilove","orcid":"https://orcid.org/0000-0002-2967-4493","observed_orcids":["https://orcid.org/0000-0002-2967-4493"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janice Gabrilove","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103695409","display_name":"Samuel Waxman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samuel Waxman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013338910","display_name":"Yongkui Jing","orcid":"https://orcid.org/0000-0002-7915-8593","observed_orcids":["https://orcid.org/0000-0002-7915-8593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongkui Jing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.16030000150203705,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9750000238418579},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9599999785423279},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6309999823570251},{"id":"https://openalex.org/keywords/leukemia-cell-differentiation","display_name":"leukemia cell differentiation","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.8977593183517456},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7098119854927063},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5565982460975647},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49891066551208496},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3950692415237427},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35095125436782837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3287650942802429},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2585054636001587},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24638032913208008},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12932944297790527},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.050722718238830566}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22457546","doi":"https://doi.org/10.1158/1078-0432.22457546","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22457546","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22457546","doi":"https://doi.org/10.1158/1078-0432.22457546","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22457546","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2215293059","https://openalex.org/W4361951438","https://openalex.org/W2083815446","https://openalex.org/W1593993073","https://openalex.org/W3192688371","https://openalex.org/W2765793833","https://openalex.org/W2053585518","https://openalex.org/W3198703646","https://openalex.org/W2492186994","https://openalex.org/W2547136458"],"abstract_inverted_index":{"Combined":[0],"effects":[1],"of":[2],"ATRA":[3],"with":[4],"MEK":[5],"inhibitors":[6],"in":[7],"HL-60":[8],"cells":[9]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2023-04-05T00:00:00"}