{"id":"https://openalex.org/W4361883230","doi":"https://doi.org/10.1158/1078-0432.22452009","title":"Supplementary Figure 1 from CpG Island Methylator Phenotype\u2013Positive Tumors in the Absence of MLH1 Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor Prognosis","display_name":"Supplementary Figure 1 from CpG Island Methylator Phenotype\u2013Positive Tumors in the Absence of MLH1 Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor Prognosis","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361883230","doi":"https://doi.org/10.1158/1078-0432.22452009"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22452009","doi":"https://doi.org/10.1158/1078-0432.22452009","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22452009","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_CpG_Island_Methylator_Phenotype_Positive_Tumors_in_the_Absence_of_i_MLH1_i_Methylation_Constitute_a_Distinct_Subset_of_Duodenal_Adenocarcinomas_and_Are_Associated_with_Poor_Prognosis/22452009/1/files/39903087.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_CpG_Island_Methylator_Phenotype_Positive_Tumors_in_the_Absence_of_i_MLH1_i_Methylation_Constitute_a_Distinct_Subset_of_Duodenal_Adenocarcinomas_and_Are_Associated_with_Poor_Prognosis/22452009/1/files/39903087.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039609611","display_name":"Tao Fu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Fu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070324294","display_name":"Emmanouil P. Pappou","orcid":"https://orcid.org/0000-0002-8735-1852","observed_orcids":["https://orcid.org/0000-0002-8735-1852"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emmanouil P. Pappou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040255726","display_name":"Angela A. Guzzetta","orcid":"https://orcid.org/0009-0009-1286-6059","observed_orcids":["https://orcid.org/0009-0009-1286-6059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angela A. Guzzetta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066423730","display_name":"Jana Jeschke","orcid":"https://orcid.org/0000-0002-6047-2558","observed_orcids":["https://orcid.org/0000-0002-6047-2558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jana Jeschke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069847600","display_name":"Ruby Kwak","orcid":"https://orcid.org/0000-0002-2314-4088","observed_orcids":["https://orcid.org/0000-0002-2314-4088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruby Kwak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024249898","display_name":"Pujan Dave","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pujan Dave","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104276309","display_name":"Craig M. Hooker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Craig M. Hooker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Morgan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Morgan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058612163","display_name":"Stephen B. Baylin","orcid":"https://orcid.org/0000-0003-3697-3798","observed_orcids":["https://orcid.org/0000-0003-3697-3798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen B. Baylin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043757838","display_name":"Christine A. Iacobuzio\u2013Donahue","orcid":"https://orcid.org/0000-0002-4672-3023","observed_orcids":["https://orcid.org/0000-0002-4672-3023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine A. Iacobuzio-Donahue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051619233","display_name":"Christopher L. Wolfgang","orcid":"https://orcid.org/0009-0000-5817-6146","observed_orcids":["https://orcid.org/0009-0000-5817-6146"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher L. Wolfgang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5114001695","display_name":"Nita Ahuja","orcid":"https://orcid.org/0000-0001-8293-1893","observed_orcids":["https://orcid.org/0000-0001-8293-1893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nita Ahuja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6137999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6137999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.33500000834465027,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cimp","display_name":"CpG island methylator phenotype","score":0.9169999957084656},{"id":"https://openalex.org/keywords/duodenal-adenocarcinoma","display_name":"duodenal adenocarcinoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/mlh1-promoter-methylation","display_name":"MLH1 promoter methylation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/methylation-specific-pcr","display_name":"methylation-specific PCR","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C111425858","wikidata":"https://www.wikidata.org/wiki/Q14911708","display_name":"MLH1","level":5,"score":0.7995330095291138},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7577353715896606},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6602761149406433},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.5789408683776855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5127652287483215},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47918736934661865},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44253838062286377},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27066826820373535},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2689365744590759},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1777345836162567},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.17181342840194702},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15855678915977478},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07493659853935242},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.07347854971885681}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.22452009","doi":"https://doi.org/10.1158/1078-0432.22452009","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22452009","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_CpG_Island_Methylator_Phenotype_Positive_Tumors_in_the_Absence_of_i_MLH1_i_Methylation_Constitute_a_Distinct_Subset_of_Duodenal_Adenocarcinomas_and_Are_Associated_with_Poor_Prognosis/22452009/1/files/39903087.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22452009.v1","doi":"https://doi.org/10.1158/1078-0432.22452009.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22452009.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22452009","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_CpG_Island_Methylator_Phenotype_Positive_Tumors_in_the_Absence_of_i_MLH1_i_Methylation_Constitute_a_Distinct_Subset_of_Duodenal_Adenocarcinomas_and_Are_Associated_with_Poor_Prognosis/22452009","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22452009","doi":"https://doi.org/10.1158/1078-0432.22452009","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22452009","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_CpG_Island_Methylator_Phenotype_Positive_Tumors_in_the_Absence_of_i_MLH1_i_Methylation_Constitute_a_Distinct_Subset_of_Duodenal_Adenocarcinomas_and_Are_Associated_with_Poor_Prognosis/22452009/1/files/39903087.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361883230.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2095785927","https://openalex.org/W1978850955","https://openalex.org/W2144936572","https://openalex.org/W2060647968","https://openalex.org/W2579134885","https://openalex.org/W7037759769","https://openalex.org/W2046845749","https://openalex.org/W2029843689","https://openalex.org/W4299394678","https://openalex.org/W2102458283"],"abstract_inverted_index":{"PDF":[0],"file,":[1],"382K,":[2],"Summary":[3],"of":[4,28],"promoter":[5],"hypermethylation":[6],"frequency":[7],"in":[8],"CIMP\u2212":[9],"and":[10,20],"CIMP+":[11],"duodenal":[12],"adenocarcinomas":[13],"as":[14],"detected":[15],"by":[16],"methylation-specific":[17],"PCR.":[18],"Black":[19],"gray":[21],"boxes":[22],"indicate":[23],"the":[24],"presence":[25],"or":[26],"absence":[27],"hypermethylation,":[29],"respectively.":[30]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}