{"id":"https://openalex.org/W4361879705","doi":"https://doi.org/10.1158/1055-9965.22438194","title":"Supplementary Figure S1. HPV capture methodology from Targeted, Deep Sequencing Reveals Full Methylation Profiles of Multiple HPV Types and Potential Biomarkers for Cervical Cancer Progression","display_name":"Supplementary Figure S1. HPV capture methodology from Targeted, Deep Sequencing Reveals Full Methylation Profiles of Multiple HPV Types and Potential Biomarkers for Cervical Cancer Progression","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361879705","doi":"https://doi.org/10.1158/1055-9965.22438194"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.22438194","doi":"https://doi.org/10.1158/1055-9965.22438194","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1055-9965.22438194","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1055-9965.22438194","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100714941","display_name":"Pengyuan Liu","orcid":"https://orcid.org/0000-0002-5443-5910","observed_orcids":["https://orcid.org/0000-0002-5443-5910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pengyuan Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068985284","display_name":"Marissa Iden","orcid":"https://orcid.org/0000-0003-3383-1751","observed_orcids":["https://orcid.org/0000-0003-3383-1751"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marissa Iden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111269375","display_name":"Samantha Fye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samantha Fye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106976513","display_name":"Yi\u2010Wen Huang","orcid":"https://orcid.org/0000-0002-5196-7030","observed_orcids":["https://orcid.org/0000-0002-5196-7030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-Wen Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111833667","display_name":"Elizabeth E. Hopp","orcid":"https://orcid.org/0000-0002-0577-0501","observed_orcids":["https://orcid.org/0000-0002-0577-0501"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Hopp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741514","display_name":"Chu Chen","orcid":"https://orcid.org/0000-0002-2280-4523","observed_orcids":["https://orcid.org/0000-0002-2280-4523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen Chu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100729292","display_name":"Yan L\u00fc","orcid":"https://orcid.org/0000-0001-7159-879X","observed_orcids":["https://orcid.org/0000-0001-7159-879X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017254635","display_name":"Janet Sue Rader","orcid":"https://orcid.org/0000-0001-7031-3385","observed_orcids":["https://orcid.org/0000-0001-7031-3385"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janet S. Rader","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9139999747276306},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.753000020980835},{"id":"https://openalex.org/keywords/cervical-cancer-progression","display_name":"cervical cancer progression","score":0.7870000004768372},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6610000133514404},{"id":"https://openalex.org/keywords/targeted-deep-sequencing","display_name":"targeted deep sequencing","score":0.9459999799728394},{"id":"https://openalex.org/keywords/bisulfite-sequencing","display_name":"bisulfite sequencing","score":0.675000011920929},{"id":"https://openalex.org/keywords/library-preparation","display_name":"library preparation","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C204628709","wikidata":"https://www.wikidata.org/wiki/Q864854","display_name":"Biotinylation","level":2,"score":0.5304932594299316},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.5297967791557312},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5175692439079285},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5123482942581177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48238101601600647},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4375007748603821},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.436245322227478},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.43553948402404785},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4225037097930908},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36335211992263794},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2230345904827118},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1055-9965.22438194","doi":"https://doi.org/10.1158/1055-9965.22438194","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1055-9965.22438194","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.22438194","doi":"https://doi.org/10.1158/1055-9965.22438194","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1055-9965.22438194","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361901550","https://openalex.org/W4361901274","https://openalex.org/W4361879466","https://openalex.org/W4361901266","https://openalex.org/W4417118415","https://openalex.org/W185249840","https://openalex.org/W2568741003","https://openalex.org/W2020225326","https://openalex.org/W4361942506","https://openalex.org/W1967698392"],"abstract_inverted_index":{"(1)":[0],"Genomic":[1],"DNA":[2],"(gDNA)":[3],"was":[4,24,55],"sheared":[5],"into":[6],"~300":[7],"bp":[8],"fragments":[9],"that":[10],"were":[11,40,61,68,81,93,107],"end-repaired,":[12],"adenylated,":[13],"and":[14,32,44,58],"ligated":[15],"to":[16,42,76,86,95],"Illumina":[17,111],"TruSeq":[18,89],"adapters.":[19],"(2)":[20],"The":[21],"prepared":[22],"library":[23],"hybridized":[25],"with":[26,70,83,98],"Agilent's":[27],"Custom":[28],"HPV":[29],"Capture":[30],"Library":[31],"IDT's":[33],"xGen":[34],"Lockdown":[35],"Probes.":[36],"(3)":[37],"Streptavidin-coated":[38],"beads":[39],"used":[41],"target":[43],"separate":[45],"the":[46,50,87,110],"5'-biotinylated":[47],"end":[48],"of":[49],"bound":[51],"hybrids.":[52],"Unbound":[53],"gDNA":[54],"washed":[56],"away,":[57],"captured":[59],"hybrids":[60,80],"eluted.":[62],"(4)":[63],"For":[64],"methylation":[65],"analysis,":[66],"samples":[67],"treated":[69],"BS,":[71],"which":[72],"converts":[73],"unmethylated":[74],"cytosines":[75],"uracil.":[77],"(5)":[78],"Captured":[79],"PCR-amplified":[82],"primers":[84],"specific":[85],"Illumnia":[88],"Adapters.":[90],"Finally,":[91],"libraries":[92,106],"indexed":[94],"provide":[96],"each":[97],"a":[99],"unique":[100],"6":[101],"base":[102],"pair":[103],"code.":[104],"Pooled":[105],"sequenced":[108],"using":[109],"HiSeq":[112],"2000":[113],"workflow.":[114]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2023-04-05T00:00:00"}
