{"id":"https://openalex.org/W4361876265","doi":"https://doi.org/10.1158/0008-5472.22419287","title":"NK cells mediate synergistic antitumor effects of combined inhibition of HDAC6 and BET in a SCLC preclinical model from NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model","display_name":"NK cells mediate synergistic antitumor effects of combined inhibition of HDAC6 and BET in a SCLC preclinical model from NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361876265","doi":"https://doi.org/10.1158/0008-5472.22419287"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22419287","doi":"https://doi.org/10.1158/0008-5472.22419287","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22419287","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22419287","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yan Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100317610","display_name":"Yuyang Li","orcid":"https://orcid.org/0000-0001-8489-3296","observed_orcids":["https://orcid.org/0000-0001-8489-3296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuyang Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058532984","display_name":"Shengwu Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shengwu Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026258084","display_name":"Dennis O. Adeegbe","orcid":"https://orcid.org/0000-0001-9233-3328","observed_orcids":["https://orcid.org/0000-0001-9233-3328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis O. Adeegbe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013721197","display_name":"Camilla Laulund Christensen","orcid":"https://orcid.org/0009-0007-3313-2615","observed_orcids":["https://orcid.org/0009-0007-3313-2615"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camilla L. Christensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065891566","display_name":"Max M. Quinn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Max M. Quinn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000624568","display_name":"Ruben Dries","orcid":"https://orcid.org/0000-0001-7650-7754","observed_orcids":["https://orcid.org/0000-0001-7650-7754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruben Dries","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102508016","display_name":"Shiwei Han","orcid":"https://orcid.org/0009-0002-4264-6320","observed_orcids":["https://orcid.org/0009-0002-4264-6320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiwei Han","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063189800","display_name":"Kevin A. Buczkowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Buczkowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071614134","display_name":"Xiaoen Wang","orcid":"https://orcid.org/0000-0001-7713-7062","observed_orcids":["https://orcid.org/0000-0001-7713-7062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoen Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443212","display_name":"Ting Chen","orcid":"https://orcid.org/0000-0003-1725-7956","observed_orcids":["https://orcid.org/0000-0003-1725-7956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ting Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362398","display_name":"Peng Gao","orcid":"https://orcid.org/0000-0002-1290-6972","observed_orcids":["https://orcid.org/0000-0002-1290-6972"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408674","display_name":"Hua Zhang","orcid":"https://orcid.org/0000-0001-7704-4712","observed_orcids":["https://orcid.org/0000-0001-7704-4712","https://orcid.org/0000-0002-4700-5971"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100325819","display_name":"Fei Li","orcid":"https://orcid.org/0000-0002-3989-8124","observed_orcids":["https://orcid.org/0000-0002-3989-8124","https://orcid.org/0009-0009-7325-2923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004171995","display_name":"Peter S. Hammerman","orcid":"https://orcid.org/0009-0006-9143-899X","observed_orcids":["https://orcid.org/0009-0006-9143-899X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter S. Hammerman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110274677","display_name":"James E. Bradner","orcid":"https://orcid.org/0000-0002-2718-4415","observed_orcids":["https://orcid.org/0000-0002-2718-4415","https://orcid.org/0000-0003-1422-5318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James E. Bradner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110477505","display_name":"Steven N. Quayle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven N. Quayle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019034689","display_name":"Kwok\u2010Kin Wong","orcid":"https://orcid.org/0000-0001-6323-235X","observed_orcids":["https://orcid.org/0000-0001-6323-235X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kwok-Kin Wong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hdac6-inhibition","display_name":"HDAC6 inhibition","score":0.9409999847412109},{"id":"https://openalex.org/keywords/bet-inhibition","display_name":"BET inhibition","score":0.8220000267028809},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9409999847412109},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/synergistic-antitumor-effect","display_name":"synergistic antitumor effect","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C23681527","wikidata":"https://www.wikidata.org/wiki/Q18034953","display_name":"HDAC6","level":5,"score":0.7234493494033813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4049660563468933},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37710845470428467},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37376511096954346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27955162525177},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1861897110939026},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11351007223129272},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.09484556317329407},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.07174205780029297}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.22419287","doi":"https://doi.org/10.1158/0008-5472.22419287","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22419287","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22419287","doi":"https://doi.org/10.1158/0008-5472.22419287","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22419287","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361876333","https://openalex.org/W4361876323","https://openalex.org/W4362422558","https://openalex.org/W4361876317","https://openalex.org/W4362422484","https://openalex.org/W2803891124","https://openalex.org/W4361824174","https://openalex.org/W4307291218","https://openalex.org/W7171425547","https://openalex.org/W3036811635"],"abstract_inverted_index":{"This":[0],"section":[1],"contains":[2],"10":[3],"supplemental":[4],"figures":[5],"and":[6],"related":[7],"figure":[8],"legends.":[9]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-04-05T00:00:00"}
