{"id":"https://openalex.org/W4361875941","doi":"https://doi.org/10.1158/0008-5472.22415310","title":"Figure S5 from Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities","display_name":"Figure S5 from Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361875941","doi":"https://doi.org/10.1158/0008-5472.22415310"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22415310","doi":"https://doi.org/10.1158/0008-5472.22415310","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22415310","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22415310","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084440384","display_name":"Andr\u00e9s M\u00e9ndez\u2010Lucas","orcid":"https://orcid.org/0000-0002-0725-4375","observed_orcids":["https://orcid.org/0000-0002-0725-4375"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andr\u00e9s M\u00e9ndez-Lucas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100366457","display_name":"Xiaolei Li","orcid":"https://orcid.org/0000-0002-2697-6496","observed_orcids":["https://orcid.org/0000-0002-2697-6496","https://orcid.org/0000-0001-7777-1004"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaolei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101982146","display_name":"Junjie Hu","orcid":"https://orcid.org/0000-0002-5750-0511","observed_orcids":["https://orcid.org/0000-0002-5750-0511","https://orcid.org/0009-0009-5098-9025"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junjie Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046126034","display_name":"Li Che","orcid":"https://orcid.org/0000-0001-7971-8725","observed_orcids":["https://orcid.org/0000-0001-7971-8725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Che","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031681400","display_name":"Xinhua Song","orcid":"https://orcid.org/0000-0002-8232-6869","observed_orcids":["https://orcid.org/0000-0002-8232-6869"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinhua Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044408202","display_name":"Jiaoyuan Jia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiaoyuan Jia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040373155","display_name":"Jingxiao Wang","orcid":"https://orcid.org/0000-0002-7799-781X","observed_orcids":["https://orcid.org/0000-0002-7799-781X","https://orcid.org/0000-0002-3807-7754","https://orcid.org/0000-0001-8070-9543"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingxiao Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017503976","display_name":"Chencheng Xie","orcid":"https://orcid.org/0000-0002-5781-2697","observed_orcids":["https://orcid.org/0000-0002-5781-2697"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chencheng Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091420663","display_name":"Paul C. Driscoll","orcid":"https://orcid.org/0000-0002-4124-6950","observed_orcids":["https://orcid.org/0000-0002-4124-6950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul C. Driscoll","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063809621","display_name":"Darjus Felix Tschaharganeh","orcid":"https://orcid.org/0000-0002-2369-5138","observed_orcids":["https://orcid.org/0000-0002-2369-5138"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darjus F. Tschaharganeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091038323","display_name":"Diego Francesco Calvisi","orcid":"https://orcid.org/0000-0002-6038-8567","observed_orcids":["https://orcid.org/0000-0002-6038-8567"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diego F. Calvisi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005740304","display_name":"Mariia O. Yuneva","orcid":"https://orcid.org/0000-0003-3455-9374","observed_orcids":["https://orcid.org/0000-0003-3455-9374"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariia Yuneva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100363101","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-9588-0164","observed_orcids":["https://orcid.org/0000-0002-9588-0164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.7860000133514404},{"id":"https://openalex.org/keywords/pkm2","display_name":"PKM2","score":0.7960000038146973},{"id":"https://openalex.org/keywords/pyruvate-kinase","display_name":"pyruvate kinase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pklr","display_name":"PKLR gene","score":0.7789999842643738},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.7490000128746033},{"id":"https://openalex.org/keywords/liver-tumors","display_name":"liver tumors","score":0.8510000109672546},{"id":"https://openalex.org/keywords/glucose-catabolism","display_name":"glucose catabolism","score":0.9729999899864197},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C10730799","wikidata":"https://www.wikidata.org/wiki/Q18030568","display_name":"PKM2","level":5,"score":0.918580174446106},{"id":"https://openalex.org/C2780854706","wikidata":"https://www.wikidata.org/wiki/Q900970","display_name":"Pyruvate kinase","level":4,"score":0.835720419883728},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.6844735145568848},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5542558431625366},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48223409056663513},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44787460565567017},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3981020450592041},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31828978657722473},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.30268651247024536},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2936133146286011}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.22415310","doi":"https://doi.org/10.1158/0008-5472.22415310","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22415310","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22415310","doi":"https://doi.org/10.1158/0008-5472.22415310","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22415310","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362422084","https://openalex.org/W4361876039","https://openalex.org/W4362422094","https://openalex.org/W4361876035","https://openalex.org/W4362422165","https://openalex.org/W4361876049","https://openalex.org/W4361824194","https://openalex.org/W2653605117","https://openalex.org/W4362422087","https://openalex.org/W3145082570"],"abstract_inverted_index":{"PKM2":[0],"and":[1,6],"PKLR":[2],"expression":[3],"in":[4],"c-MYC-shLuc/MCL1":[5],"c-MYC-shPKM/MCL1":[7],"tumors":[8]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-04-05T00:00:00"}