{"id":"https://openalex.org/W4361863296","doi":"https://doi.org/10.1158/1055-9965.c.6515293","title":"Data from Bioavailable Insulin-like Growth Factor-I Inversely Related to Weight Gain in Postmenopausal Women Regardless of Exogenous Estrogen","display_name":"Data from Bioavailable Insulin-like Growth Factor-I Inversely Related to Weight Gain in Postmenopausal Women Regardless of Exogenous Estrogen","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361863296","doi":"https://doi.org/10.1158/1055-9965.c.6515293"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.c.6515293","doi":"https://doi.org/10.1158/1055-9965.c.6515293","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6515293","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1055-9965.c.6515293","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012046553","display_name":"Su Yon Jung","orcid":"https://orcid.org/0000-0002-0513-1830","observed_orcids":["https://orcid.org/0000-0002-0513-1830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Su Yon Jung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036400845","display_name":"Stephen David Hursting","orcid":"https://orcid.org/0000-0003-3605-2833","observed_orcids":["https://orcid.org/0000-0003-3605-2833"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen D. Hursting","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065405793","display_name":"Michele Guindani","orcid":"https://orcid.org/0000-0002-6363-9907","observed_orcids":["https://orcid.org/0000-0002-6363-9907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michele Guindani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009980709","display_name":"Mara Z. Vitolins","orcid":"https://orcid.org/0000-0002-0348-0113","observed_orcids":["https://orcid.org/0000-0002-0348-0113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mara Z. Vitolins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029182022","display_name":"Electra D. Paskett","orcid":"https://orcid.org/0000-0002-8247-8299","observed_orcids":["https://orcid.org/0000-0002-8247-8299","https://orcid.org/0000-0002-0720-938X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Electra Paskett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084454043","display_name":"Shine Chang","orcid":"https://orcid.org/0000-0003-3804-9697","observed_orcids":["https://orcid.org/0000-0003-3804-9697"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shine Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9729999899864197},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.9620000123977661},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9940000176429749},{"id":"https://openalex.org/keywords/exogenous-estrogen","display_name":"exogenous estrogen","score":0.875},{"id":"https://openalex.org/keywords/igf-binding-protein-3","display_name":"IGF binding protein-3","score":0.8669999837875366},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6430000066757202},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.8579999804496765},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.765999972820282},{"id":"https://openalex.org/keywords/women-s-health-initiative","display_name":"Women's Health Initiative","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.7372100949287415},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.7000604271888733},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6910837888717651},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6843050122261047},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.6391280889511108},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6289321184158325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5212829113006592},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.47842270135879517},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4760998487472534},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.4206504821777344},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.41158127784729004},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.2724992036819458},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14369353652000427},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1055-9965.c.6515293","doi":"https://doi.org/10.1158/1055-9965.c.6515293","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6515293","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.c.6515293","doi":"https://doi.org/10.1158/1055-9965.c.6515293","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6515293","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2161996207","https://openalex.org/W2151593979","https://openalex.org/W2112515570","https://openalex.org/W2037889931","https://openalex.org/W2132577252","https://openalex.org/W2528362558","https://openalex.org/W2111014150","https://openalex.org/W2526695910","https://openalex.org/W1275290832","https://openalex.org/W7099296599"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Weight":[2],"gain,":[3],"insulin-like":[4],"growth":[5],"factor-I":[6],"(IGF-I)":[7],"levels,":[8,49],"and":[9,39,50,80,88,142,171],"excess":[10],"exogenous":[11,51],"steroid":[12],"hormone":[13],"use":[14,53],"are":[15],"putative":[16],"cancer":[17,241],"risk":[18,242],"factors,":[19],"yet":[20],"their":[21],"interconnected":[22],"pathways":[23],"have":[24],"not":[25,219],"been":[26],"fully":[27],"characterized.":[28],"This":[29,58],"cross-sectional":[30],"study":[31,59,69],"investigated":[32],"the":[33,71,99,131,136,160,165,196],"relationship":[34,84],"between":[35,77,85],"plasma":[36,123],"IGF-I":[37,86,103,111,141,205,224],"levels":[38,87,112,206,225],"weight":[40,89,152,200,211,216,234],"gain":[41,90,151,184,212,217,235],"according":[42],"to":[43,104,150,183,210,239],"body":[44],"mass":[45],"index":[46],"(BMI),":[47],"leptin":[48],"estrogen":[52,188],"among":[54,226],"postmenopausal":[55,62,227],"women.":[56],"Methods:":[57],"included":[60],"794":[61],"women":[63,134,158,168,228],"who":[64],"enrolled":[65],"in":[66,135,159,169,181,223,229],"an":[67],"ancillary":[68],"of":[70,102,119,140,145,173,191,198,233],"Women's":[72],"Health":[73],"Initiative":[74],"Observational":[75],"Study":[76],"February":[78],"1995":[79],"July":[81],"1998.":[82],"The":[83,122],"was":[91,218],"analyzed":[92],"using":[93],"ordinal":[94],"logistic":[95],"regression.":[96],"We":[97],"used":[98],"molar":[100],"ratio":[101],"IGF":[105],"binding":[106],"protein-3":[107],"(IGF-I/IGFBP-3)":[108],"or":[109],"circulating":[110],"adjusting":[113],"for":[114],"IGFBP-3":[115],"as":[116,127,236],"a":[117,237],"proxy":[118],"bioavailable":[120],"IGF-I.":[121],"concentrations":[124],"were":[125,147,157,175,207],"expressed":[126],"quartiles.":[128],"Results:":[129],"Among":[130,164,186],"obese":[132],"group,":[133,167],"third":[137],"quartile":[138,144],"(Q3)":[139],"highest":[143],"IGF-I/IGFBP-3":[146,174,192],"less":[148,177],"likely":[149,178],"(>3%":[153],"from":[154],"baseline)":[155],"than":[156,179,201],"first":[161],"quartiles":[162],"(Q1).":[163],"normal-weight":[166],"Q2":[170],"Q3":[172,190],"70%":[176],"those":[180],"Q1":[182],"weight.":[185],"current":[187],"users,":[189],"had":[193],"0.5":[194],"times":[195],"odds":[197],"gaining":[199],"Q1.":[202],"Conclusions:":[203],"Bioavailable":[204],"inversely":[208],"related":[209],"overall.":[213],"Impact:":[214],"Although":[215],"consistent":[220],"with":[221],"increases":[222],"this":[230],"report,":[231],"avoidance":[232],"strategy":[238],"reduce":[240],"may":[243],"be":[244],"recommended.":[245],"Cancer":[246],"Epidemiol":[247],"Biomarkers":[248],"Prev;":[249],"23(3);":[250],"534\u201344.":[251],"\u00a92013":[252],"AACR.":[253]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2023-04-05T00:00:00"}