{"id":"https://openalex.org/W4361850485","doi":"https://doi.org/10.1158/0008-5472.22409301.v1","title":"Supplementary Figure Legend from Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations","display_name":"Supplementary Figure Legend from Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361850485","doi":"https://doi.org/10.1158/0008-5472.22409301.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22409301.v1","doi":"https://doi.org/10.1158/0008-5472.22409301.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22409301.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_Legend_from_Modulation_of_EZH2_Expression_by_MEK-ERK_or_PI3K-AKT_Signaling_in_Lung_Cancer_Is_Dictated_by_Different_KRAS_Oncogene_Mutations/22409301/1/files/39855177.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_Legend_from_Modulation_of_EZH2_Expression_by_MEK-ERK_or_PI3K-AKT_Signaling_in_Lung_Cancer_Is_Dictated_by_Different_KRAS_Oncogene_Mutations/22409301/1/files/39855177.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066180141","display_name":"Erick Marcelo Riquelme","orcid":"https://orcid.org/0000-0002-2696-7995","observed_orcids":["https://orcid.org/0000-0002-2696-7995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erick Riquelme","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009105122","display_name":"Carmen Behrens","orcid":"https://orcid.org/0000-0003-1905-8061","observed_orcids":["https://orcid.org/0000-0003-1905-8061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Behrens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074671045","display_name":"Heather Yan Lin","orcid":"https://orcid.org/0000-0002-1779-7007","observed_orcids":["https://orcid.org/0000-0002-1779-7007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heather Y. Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102964486","display_name":"George R. Simon","orcid":"https://orcid.org/0000-0002-3894-0773","observed_orcids":["https://orcid.org/0000-0002-3894-0773"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Simon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008790176","display_name":"Vassiliki A. Papadimitrakopoulou","orcid":"https://orcid.org/0000-0003-3172-1399","observed_orcids":["https://orcid.org/0000-0003-3172-1399"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vassiliki Papadimitrakopoulou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108617500","display_name":"Julie G. Izzo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Izzo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001098397","display_name":"C\u00e9sar A. Moran","orcid":"https://orcid.org/0000-0003-1158-5713","observed_orcids":["https://orcid.org/0000-0003-1158-5713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cesar Moran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103148045","display_name":"Neda Kalhor","orcid":"https://orcid.org/0000-0001-6891-6435","observed_orcids":["https://orcid.org/0000-0001-6891-6435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neda Kalhor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J. Jack Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Jack Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048865240","display_name":"John Dorrance Minna","orcid":"https://orcid.org/0000-0002-7776-0767","observed_orcids":["https://orcid.org/0000-0002-7776-0767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John D. Minna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028085268","display_name":"Ignacio Ivan Wistuba","orcid":"https://orcid.org/0000-0003-3365-6340","observed_orcids":["https://orcid.org/0000-0003-3365-6340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ignacio I. Wistuba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5532000064849854,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5532000064849854,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.20499999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.05920000001788139,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mek-erk-signaling","display_name":"MEK/ERK signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9449999928474426},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ezh2-inhibitors","display_name":"EZH2 inhibitors","score":0.8069999814033508},{"id":"https://openalex.org/keywords/selumetinib","display_name":"selumetinib","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mk-2206","display_name":"MK-2206","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gsk343","display_name":"GSK343","score":0.8209999799728394},{"id":"https://openalex.org/keywords/gsk126","display_name":"GSK126","score":0.9779999852180481},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8570080995559692},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6817300915718079},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6716173887252808},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6586634516716003},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6023010015487671},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5268988609313965},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.5133664011955261},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.42890745401382446},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3802841603755951},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3523419201374054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35137826204299927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2957010269165039},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28950703144073486},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22500577569007874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17960292100906372},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0970928966999054},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09161651134490967},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.08164763450622559},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05936324596405029},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.042296260595321655}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.22409301.v1","doi":"https://doi.org/10.1158/0008-5472.22409301.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22409301.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_Legend_from_Modulation_of_EZH2_Expression_by_MEK-ERK_or_PI3K-AKT_Signaling_in_Lung_Cancer_Is_Dictated_by_Different_KRAS_Oncogene_Mutations/22409301/1/files/39855177.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22409301","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_Legend_from_Modulation_of_EZH2_Expression_by_MEK-ERK_or_PI3K-AKT_Signaling_in_Lung_Cancer_Is_Dictated_by_Different_KRAS_Oncogene_Mutations/22409301","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22409301.v1","doi":"https://doi.org/10.1158/0008-5472.22409301.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22409301.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_Legend_from_Modulation_of_EZH2_Expression_by_MEK-ERK_or_PI3K-AKT_Signaling_in_Lung_Cancer_Is_Dictated_by_Different_KRAS_Oncogene_Mutations/22409301/1/files/39855177.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361850485.pdf","grobid_xml":"https://content.openalex.org/works/W4361850485.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2216439242","https://openalex.org/W2564508184","https://openalex.org/W4361827577","https://openalex.org/W2057385859","https://openalex.org/W2474534769","https://openalex.org/W2312585159","https://openalex.org/W3195681675","https://openalex.org/W2617472849","https://openalex.org/W2157814804","https://openalex.org/W4361950092"],"abstract_inverted_index":{"1.EZH2":[0],"and":[1,3,11,15,22,32],"MEK-ERK":[2],"PI3K/AKT":[4],"signaling":[5],"pathway":[6],"expression":[7],"in":[8,18,24,34],"lung":[9],"adenocarcinoma":[10],"HBEC":[12],"cell":[13],"lines":[14],"2.":[16],"Sensitivity":[17],"vitro":[19],"to":[20],"AZD6244":[21],"MK2206":[23],"combination":[25],"with":[26],"selective":[27],"EZH2":[28],"inhibitor":[29],"GSK343,":[30],"EPZ6438":[31],"GSK126":[33],"NSCLC":[35],"cells.":[36]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-05T00:00:00"}
