{"id":"https://openalex.org/W4361849349","doi":"https://doi.org/10.1158/0008-5472.22407198","title":"Supplementary Figure S1 from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis","display_name":"Supplementary Figure S1 from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361849349","doi":"https://doi.org/10.1158/0008-5472.22407198"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22407198","doi":"https://doi.org/10.1158/0008-5472.22407198","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22407198","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22407198","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070629256","display_name":"Shon Green","orcid":"https://orcid.org/0009-0007-4618-4609","observed_orcids":["https://orcid.org/0009-0007-4618-4609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shon Green","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004350870","display_name":"Christy L. Trejo","orcid":"https://orcid.org/0000-0001-5535-3725","observed_orcids":["https://orcid.org/0000-0001-5535-3725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christy L. Trejo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003652463","display_name":"Martin McMahon","orcid":"https://orcid.org/0000-0003-2812-1042","observed_orcids":["https://orcid.org/0000-0003-2812-1042"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin McMahon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.4368000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.4368000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.2919999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.15880000591278076,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pik3ca-h1047r","display_name":"PIK3CA H1047R","score":0.9350000023841858},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lung-carcinogenesis","display_name":"lung carcinogenesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/erk1-2-activation","display_name":"ERK1/2 activation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/akt-activation","display_name":"Akt activation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8524576425552368},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6280951499938965},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.608923614025116},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44177085161209106},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.439238965511322},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.41280269622802734},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35776209831237793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2884535789489746},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2744605541229248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24132472276687622},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2187555730342865},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2134055197238922},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11052879691123962},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10439133644104004}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.22407198","doi":"https://doi.org/10.1158/0008-5472.22407198","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22407198","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.22407198.v1","doi":"https://doi.org/10.1158/0008-5472.22407198.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22407198.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22407198","doi":"https://doi.org/10.1158/0008-5472.22407198","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22407198","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392725591","https://openalex.org/W2241377864","https://openalex.org/W2172561271","https://openalex.org/W3174777841","https://openalex.org/W2520198980","https://openalex.org/W4393093949","https://openalex.org/W3093086801","https://openalex.org/W2809593667","https://openalex.org/W7165040775","https://openalex.org/W4361240282"],"abstract_inverted_index":{"Comparison":[0],"of":[1],"ERK1/2":[2],"and":[3],"AKT":[4],"activation":[5],"in":[6],"KRASG12D-":[7],"versus":[8],"KRASG12D/PIK3CAH1047R-driven":[9],"lung":[10],"tumors.":[11]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}