{"id":"https://openalex.org/W4361848592","doi":"https://doi.org/10.1158/0008-5472.22403955.v1","title":"Data Supplement from Definition of PKC-\u03b1, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer","display_name":"Data Supplement from Definition of PKC-\u03b1, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361848592","doi":"https://doi.org/10.1158/0008-5472.22403955.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22403955.v1","doi":"https://doi.org/10.1158/0008-5472.22403955.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22403955.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22403955.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030972065","display_name":"Yi-Hsin Elsa Hsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-Hsin Hsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088507691","display_name":"Jun Yao","orcid":"https://orcid.org/0000-0002-3472-1602","observed_orcids":["https://orcid.org/0000-0002-3472-1602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Yao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071293792","display_name":"Li-Chuan Chan","orcid":"https://orcid.org/0000-0002-2665-637X","observed_orcids":["https://orcid.org/0000-0002-2665-637X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-Chuan Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073051320","display_name":"Ting-Jung Wu","orcid":"https://orcid.org/0000-0001-8911-8758","observed_orcids":["https://orcid.org/0000-0001-8911-8758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ting-Jung Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018650939","display_name":"Jennifer L. Hsu","orcid":"https://orcid.org/0000-0001-9920-0720","observed_orcids":["https://orcid.org/0000-0001-9920-0720"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer L. Hsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009721499","display_name":"Yueh\u2010Fu Fang","orcid":"https://orcid.org/0000-0003-2211-3076","observed_orcids":["https://orcid.org/0000-0003-2211-3076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yueh-Fu Fang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109411868","display_name":"Yongkun Wei","orcid":"https://orcid.org/0000-0001-8998-5333","observed_orcids":["https://orcid.org/0000-0001-8998-5333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongkun Wei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111704919","display_name":"Yun Wu","orcid":"https://orcid.org/0009-0007-9248-2404","observed_orcids":["https://orcid.org/0009-0007-9248-2404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062806463","display_name":"Wen\u2010Chien Huang","orcid":"https://orcid.org/0000-0002-9482-8188","observed_orcids":["https://orcid.org/0000-0002-9482-8188"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-Chien Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102902754","display_name":"Chien\u2010Liang Liu","orcid":"https://orcid.org/0000-0001-8127-588X","observed_orcids":["https://orcid.org/0000-0001-8127-588X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chien-Liang Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053516664","display_name":"Yuan\u2010Ching Chang","orcid":"https://orcid.org/0000-0001-7625-606X","observed_orcids":["https://orcid.org/0000-0001-7625-606X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan-Ching Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348323","display_name":"Mingyang Wang","orcid":"https://orcid.org/0000-0001-7201-5090","observed_orcids":["https://orcid.org/0000-0001-7201-5090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming-Yang Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035895874","display_name":"Chia-Wei Li","orcid":"https://orcid.org/0000-0002-6280-0877","observed_orcids":["https://orcid.org/0000-0002-6280-0877"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chia-Wei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101475015","display_name":"Jia Shen","orcid":"https://orcid.org/0000-0002-4983-2049","observed_orcids":["https://orcid.org/0000-0002-4983-2049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089455074","display_name":"Mei\u2010Kuang Chen","orcid":"https://orcid.org/0000-0001-8027-8990","observed_orcids":["https://orcid.org/0000-0001-8027-8990"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mei-Kuang Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041098535","display_name":"Ay\u015feg\u00fcl A. \u015eahin","orcid":"https://orcid.org/0000-0001-8259-9624","observed_orcids":["https://orcid.org/0000-0001-8259-9624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aysegul A. Sahin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100640276","display_name":"Anil K. Sood","orcid":"https://orcid.org/0000-0002-5415-9901","observed_orcids":["https://orcid.org/0000-0002-5415-9901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anil Sood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040450464","display_name":"Dihua Yu","orcid":"https://orcid.org/0000-0001-6231-9381","observed_orcids":["https://orcid.org/0000-0001-6231-9381"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dihua Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018617106","display_name":"Gabriel N. Hortob\u00e1gyi","orcid":"https://orcid.org/0000-0002-4873-4412","observed_orcids":["https://orcid.org/0000-0002-4873-4412","https://orcid.org/0000-0001-9030-4136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel N. Hortobagyi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076834432","display_name":"Mien\u2010Chie Hung","orcid":"https://orcid.org/0000-0003-4317-4740","observed_orcids":["https://orcid.org/0000-0003-4317-4740"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mien-Chie Hung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/protein-kinase-c-alpha","display_name":"protein kinase C alpha","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cdk6","display_name":"CDK6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/met","display_name":"MET","score":0.9950000047683716},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9760000109672546},{"id":"https://openalex.org/keywords/trio","display_name":"trios","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epha4","display_name":"EphA4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diacylglycerol-kinase-alpha","display_name":"diacylglycerol kinase alpha","score":0.9950000047683716},{"id":"https://openalex.org/keywords/erk5","display_name":"ERK5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6204549670219421},{"id":"https://openalex.org/C199649820","wikidata":"https://www.wikidata.org/wiki/Q14911762","display_name":"Cyclin-dependent kinase 6","level":5,"score":0.6174959540367126},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.5787985920906067},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.5748015642166138},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5541766881942749},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49901723861694336},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4699530601501465},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39249420166015625},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3840184211730957},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.24489399790763855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2088596522808075},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.11750206351280212},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09229639172554016},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.22403955.v1","doi":"https://doi.org/10.1158/0008-5472.22403955.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22403955.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22403955","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Data_Supplement_from_Definition_of_PKC-_CDK6_and_MET_as_Therapeutic_Targets_in_Triple-Negative_Breast_Cancer/22403955","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22403955.v1","doi":"https://doi.org/10.1158/0008-5472.22403955.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22403955.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392680158","https://openalex.org/W2074550517","https://openalex.org/W2810929070","https://openalex.org/W4361257366","https://openalex.org/W3093318942","https://openalex.org/W2759118902","https://openalex.org/W3033176457","https://openalex.org/W4409632373","https://openalex.org/W4322774578","https://openalex.org/W2989902053"],"abstract_inverted_index":{"Supplementary":[0,16],"Figure":[1,17],"S1.":[2],"The":[3],"mRNA":[4],"expression":[5],"of":[6,20],"MAP4K5,":[7],"TRIO,":[8],"EPHA4,":[9],"DGKA":[10],"and":[11,23],"MAPK7":[12],"in":[13],"TNBC":[14],"cells":[15],"S2.":[18],"Inhibition":[19],"PKC-alpha,":[21],"MET,":[22],"CDK6":[24],"reduced":[25],"stem":[26],"cell-like":[27],"population.":[28]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-04-05T00:00:00"}