{"id":"https://openalex.org/W4361847714","doi":"https://doi.org/10.1158/0008-5472.c.6510333","title":"Data from Heterochromatin Protein 1\u03b1 Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer","display_name":"Data from Heterochromatin Protein 1\u03b1 Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361847714","doi":"https://doi.org/10.1158/0008-5472.c.6510333"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6510333","doi":"https://doi.org/10.1158/0008-5472.c.6510333","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6510333","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6510333","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066010480","display_name":"Xinpei Ci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinpei Ci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100550950","display_name":"Jun Hao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Hao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xin Dong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Dong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110325","display_name":"Stephen Yiu Chuen Choi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Y. Choi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337749","display_name":"Hui Xue","orcid":"https://orcid.org/0000-0002-3291-8516","observed_orcids":["https://orcid.org/0000-0002-3291-8516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Xue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044863806","display_name":"Rebecca Wu","orcid":"https://orcid.org/0000-0002-8065-4498","observed_orcids":["https://orcid.org/0000-0002-8065-4498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062170341","display_name":"Sifeng Qu","orcid":"https://orcid.org/0000-0002-3099-489X","observed_orcids":["https://orcid.org/0000-0002-3099-489X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sifeng Qu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110467","display_name":"Peter W. Gout","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter W. Gout","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100367233","display_name":"Fang Zhang","orcid":"https://orcid.org/0000-0002-2799-3220","observed_orcids":["https://orcid.org/0000-0002-2799-3220"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fang Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058224880","display_name":"Anne M. Haegert","orcid":"https://orcid.org/0000-0002-0738-2270","observed_orcids":["https://orcid.org/0000-0002-0738-2270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne M. Haegert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034110828","display_name":"Ladan Fazli","orcid":"https://orcid.org/0009-0005-0731-0583","observed_orcids":["https://orcid.org/0009-0005-0731-0583","https://orcid.org/0000-0001-6488-4245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ladan Fazli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029919899","display_name":"Francesco Crea","orcid":"https://orcid.org/0000-0002-4903-2973","observed_orcids":["https://orcid.org/0000-0002-4903-2973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Crea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073231763","display_name":"Christopher John Ong","orcid":"https://orcid.org/0000-0002-0175-8724","observed_orcids":["https://orcid.org/0000-0002-0175-8724"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher J. Ong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081653545","display_name":"Amina Zoubeidi","orcid":"https://orcid.org/0000-0002-0498-142X","observed_orcids":["https://orcid.org/0000-0002-0498-142X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amina Zoubeidi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050721657","display_name":"Housheng Hansen He","orcid":"https://orcid.org/0000-0003-2898-3363","observed_orcids":["https://orcid.org/0000-0003-2898-3363"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Housheng H. He","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062125605","display_name":"Martin Edwin Gleave","orcid":"https://orcid.org/0000-0003-4235-0167","observed_orcids":["https://orcid.org/0000-0003-4235-0167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin E. Gleave","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050325886","display_name":"Colin C. Collins","orcid":"https://orcid.org/0000-0001-6148-6110","observed_orcids":["https://orcid.org/0000-0001-6148-6110","https://orcid.org/0009-0009-3987-4294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Colin C. Collins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100325679","display_name":"Dong Lin","orcid":"https://orcid.org/0000-0002-0303-2599","observed_orcids":["https://orcid.org/0000-0002-0303-2599"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100665235","display_name":"Yuzhuo Z. Wang","orcid":"https://orcid.org/0000-0002-9749-8591","observed_orcids":["https://orcid.org/0000-0002-9749-8591"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuzhuo Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroendocrine-prostate-cancer","display_name":"neuroendocrine prostate cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.8870000243186951},{"id":"https://openalex.org/keywords/neuroendocrine-transdifferentiation","display_name":"neuroendocrine transdifferentiation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.7649999856948853},{"id":"https://openalex.org/keywords/re1-silencing-transcription-factor","display_name":"RE1-silencing transcription factor","score":0.968999981880188},{"id":"https://openalex.org/keywords/h3k9-trimethylation","display_name":"H3K9 trimethylation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hyperchromatic-nuclei","display_name":"hyperchromatic nuclei","score":0.7699999809265137},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.6940000057220459},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.650799572467804},{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.6038645505905151},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.602356493473053},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5378484129905701},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5361928939819336},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.46039313077926636},{"id":"https://openalex.org/C92149661","wikidata":"https://www.wikidata.org/wiki/Q1616164","display_name":"Heterochromatin protein 1","level":5,"score":0.45905885100364685},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.45273134112358093},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.43309077620506287},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.41531169414520264},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35412830114364624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30926385521888733},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27701321244239807},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.2580810487270355},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24282777309417725},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21438142657279968}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.c.6510333","doi":"https://doi.org/10.1158/0008-5472.c.6510333","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6510333","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.c.6510333.v1","doi":"https://doi.org/10.1158/0008-5472.c.6510333.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6510333.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6510333","doi":"https://doi.org/10.1158/0008-5472.c.6510333","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6510333","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2794019020","https://openalex.org/W2887237327","https://openalex.org/W2794083765","https://openalex.org/W4362522868","https://openalex.org/W4404960577","https://openalex.org/W7162628031","https://openalex.org/W4401013757","https://openalex.org/W3023509255","https://openalex.org/W2808720503","https://openalex.org/W4415211333"],"abstract_inverted_index":{"Abstract":[0],"Neuroendocrine":[1],"prostate":[2,10],"cancer":[3,11],"(NEPC)":[4],"is":[5],"a":[6,43,198,218,231],"lethal":[7],"subtype":[8],"of":[9,36,47,53,86,172],"arising":[12],"mostly":[13],"from":[14],"adenocarcinoma":[15,161],"via":[16],"neuroendocrine":[17],"transdifferentiation":[18,88,159],"following":[19],"androgen":[20,165,173],"deprivation":[21,166],"therapy.":[22],"Mechanisms":[23],"contributing":[24],"to":[25,67,149,164],"both":[26],"NEPC":[27,106,114,127,134,202,223],"development":[28,107,203],"and":[29,62,103,108,125,142,175,180,217,225],"its":[30],"aggressiveness":[31],"remain":[32],"elusive.":[33],"In":[34],"light":[35],"the":[37,112,132,182],"fact":[38],"that":[39,72],"hyperchromatic":[40],"nuclei":[41],"are":[42,73],"distinguishing":[44],"histopathologic":[45],"feature":[46],"NEPC,":[48,235],"we":[49],"utilized":[50],"transcriptomic":[51],"analyses":[52],"our":[54,81],"patient-derived":[55],"xenograft":[56],"(PDX)":[57],"models,":[58],"multiple":[59,123],"clinical":[60,126],"cohorts,":[61],"genetically":[63],"engineered":[64],"mouse":[65],"models":[66],"identify":[68],"36":[69,93],"heterochromatin-related":[70,94],"genes":[71],"significantly":[74,156],"enriched":[75,181],"in":[76,111,122,131,160,234],"NEPC.":[77],"Longitudinal":[78],"analysis":[79],"using":[80],"unique,":[82],"first-in-field":[83],"PDX":[84,124],"model":[85],"adenocarcinoma-to-NEPC":[87],"revealed":[89],"that,":[90],"among":[91],"those":[92],"genes,":[95,209],"heterochromatin":[96,208],"protein":[97],"1\u03b1":[98],"(HP1\u03b1)":[99],"expression":[100,118,155,171],"increased":[101],"early":[102,214],"steadily":[104],"during":[105],"remained":[109],"elevated":[110,117],"developed":[113],"tumor.":[115],"Its":[116,153],"was":[119],"further":[120],"confirmed":[121],"samples.":[128],"HP1\u03b1":[129,169,211],"knockdown":[130],"NCI-H660":[133],"cell":[135,145],"line":[136],"inhibited":[137],"proliferation,":[138],"ablated":[139],"colony":[140],"formation,":[141],"induced":[143],"apoptotic":[144],"death,":[146],"ultimately":[147],"leading":[148],"tumor":[150],"growth":[151],"arrest.":[152],"ectopic":[154],"promoted":[157],"NE":[158],"cells":[162],"subjected":[163],"treatment.":[167],"Mechanistically,":[168],"reduced":[170],"receptor":[174],"RE1":[176],"silencing":[177],"transcription":[178],"factor":[179],"repressive":[183],"trimethylated":[184],"histone":[185],"H3":[186],"at":[187],"Lys9":[188],"mark":[189],"on":[190],"their":[191],"respective":[192],"gene":[193],"promoters.":[194],"These":[195],"observations":[196],"indicate":[197],"novel":[199],"mechanism":[200],"underlying":[201],"mediated":[204],"by":[205],"abnormally":[206],"expressed":[207],"with":[210],"as":[212],"an":[213],"functional":[215],"mediator":[216],"potential":[219],"therapeutic":[220,238],"target":[221],"for":[222,240],"prevention":[224],"management.":[226],"Significance:":[227],"Heterochromatin":[228],"proteins":[229],"play":[230],"fundamental":[232],"role":[233],"illuminating":[236],"new":[237],"targets":[239],"this":[241],"aggressive":[242],"disease.":[243],"Cancer":[244],"Res;":[245],"78(10);":[246],"2691\u2013704.":[247],"\u00a92018":[248],"AACR.":[249]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}