{"id":"https://openalex.org/W4361847222","doi":"https://doi.org/10.1158/0008-5472.22400063","title":"Supplementary Methods from Predictive Performance of Microarray Gene Signatures: Impact of Tumor Heterogeneity and Multiple Mechanisms of Drug Resistance","display_name":"Supplementary Methods from Predictive Performance of Microarray Gene Signatures: Impact of Tumor Heterogeneity and Multiple Mechanisms of Drug Resistance","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361847222","doi":"https://doi.org/10.1158/0008-5472.22400063"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22400063","doi":"https://doi.org/10.1158/0008-5472.22400063","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22400063","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.22400063","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057848295","display_name":"Charlotte K.Y. Ng","orcid":"https://orcid.org/0000-0002-6100-0026","observed_orcids":["https://orcid.org/0000-0002-6100-0026"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charlotte K.Y. Ng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040506127","display_name":"Britta Weigelt","orcid":"https://orcid.org/0000-0001-9927-1270","observed_orcids":["https://orcid.org/0000-0001-9927-1270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Britta Weigelt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040167724","display_name":"Roger A\u2019Hern","orcid":"https://orcid.org/0000-0003-0593-8391","observed_orcids":["https://orcid.org/0000-0003-0593-8391"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger A'Hern","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005286764","display_name":"Fran\u00e7ois\u2010Cl\u00e9ment Bidard","orcid":"https://orcid.org/0000-0001-5932-8949","observed_orcids":["https://orcid.org/0000-0001-5932-8949"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francois-Clement Bidard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018484667","display_name":"Christophe Lemetre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christophe Lemetre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016475369","display_name":"Charles Swanton","orcid":"https://orcid.org/0000-0002-4299-3018","observed_orcids":["https://orcid.org/0000-0002-4299-3018"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Swanton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103057800","display_name":"Ronglai Shen","orcid":"https://orcid.org/0000-0001-9694-584X","observed_orcids":["https://orcid.org/0000-0001-9694-584X","https://orcid.org/0000-0002-8192-7531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronglai Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077235697","display_name":"Jorge Sergio Reis-Filho","orcid":"https://orcid.org/0000-0003-2969-3173","observed_orcids":["https://orcid.org/0000-0003-2969-3173"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge S. Reis-Filho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.12380000203847885,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/predictive-performance","display_name":"predictive performance","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.753000020980835},{"id":"https://openalex.org/keywords/cancer-genomics","display_name":"cancer genomics","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C3018028425","wikidata":"https://www.wikidata.org/wiki/Q15917291","display_name":"Tumor heterogeneity","level":3,"score":0.621283769607544},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5798797607421875},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5512038469314575},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.531025767326355},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5204722881317139},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4770078659057617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4390489459037781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38618841767311096},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24065208435058594},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22867351770401},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17157405614852905},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15234661102294922}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.22400063","doi":"https://doi.org/10.1158/0008-5472.22400063","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22400063","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.22400063.v1","doi":"https://doi.org/10.1158/0008-5472.22400063.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22400063.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Methods_from_Predictive_Performance_of_Microarray_Gene_Signatures_Impact_of_Tumor_Heterogeneity_and_Multiple_Mechanisms_of_Drug_Resistance/22400063/1/files/39845819.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22400063","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Methods_from_Predictive_Performance_of_Microarray_Gene_Signatures_Impact_of_Tumor_Heterogeneity_and_Multiple_Mechanisms_of_Drug_Resistance/22400063","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22400063","doi":"https://doi.org/10.1158/0008-5472.22400063","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22400063","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361847222.pdf","grobid_xml":"https://content.openalex.org/works/W4361847222.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2313246865","https://openalex.org/W4361822078","https://openalex.org/W1993894040","https://openalex.org/W2946322155","https://openalex.org/W3146240351","https://openalex.org/W7065744626","https://openalex.org/W7096065981","https://openalex.org/W4245988923","https://openalex.org/W2200133433","https://openalex.org/W3213661490"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"33K,":[3],"SUPPLEMENTARY":[4],"R":[5,7],"SCRIPT:":[6],"script":[8],"and":[9],"code":[10],"that":[11],"can":[12],"be":[13],"employed":[14],"to":[15],"generate":[16],"all":[17],"results":[18],"described":[19],"in":[20],"the":[21],"manuscript.":[22]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}