{"id":"https://openalex.org/W4361845943","doi":"https://doi.org/10.1158/0008-5472.c.6511188.v1","title":"Data from Histone-Related Genes Are Hypermethylated in Lung Cancer and Hypermethylated HIST1H4F Could Serve as a Pan-Cancer Biomarker","display_name":"Data from Histone-Related Genes Are Hypermethylated in Lung Cancer and Hypermethylated HIST1H4F Could Serve as a Pan-Cancer Biomarker","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361845943","doi":"https://doi.org/10.1158/0008-5472.c.6511188.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6511188.v1","doi":"https://doi.org/10.1158/0008-5472.c.6511188.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6511188.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6511188.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101372278","display_name":"Shihua Dong","orcid":"https://orcid.org/0000-0003-3675-8801","observed_orcids":["https://orcid.org/0000-0003-3675-8801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shihua Dong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318082","display_name":"Wei Li","orcid":"https://orcid.org/0000-0001-9931-5990","observed_orcids":["https://orcid.org/0000-0001-9931-5990"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100677122","display_name":"Jie Hu","orcid":"https://orcid.org/0000-0003-4993-5758","observed_orcids":["https://orcid.org/0000-0003-4993-5758","https://orcid.org/0009-0003-6542-0081","https://orcid.org/0009-0004-0496-2298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100728617","display_name":"Yuanlin Song","orcid":"https://orcid.org/0000-0002-9826-4383","observed_orcids":["https://orcid.org/0000-0002-9826-4383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuanlin Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101688759","display_name":"Baolong Zhang","orcid":"https://orcid.org/0000-0002-4533-6929","observed_orcids":["https://orcid.org/0000-0002-4533-6929"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Baolong Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100633468","display_name":"Xiaoguang Ren","orcid":"https://orcid.org/0000-0002-8048-6762","observed_orcids":["https://orcid.org/0000-0002-8048-6762","https://orcid.org/0000-0003-2416-2031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoguang Ren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110966926","display_name":"Shimeng Ji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shimeng Ji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jin Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Peng Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414176","display_name":"Ying Liang","orcid":"https://orcid.org/0000-0002-2594-3318","observed_orcids":["https://orcid.org/0000-0002-2594-3318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Liang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389302","display_name":"Gang Chen","orcid":"https://orcid.org/0000-0002-9989-2381","observed_orcids":["https://orcid.org/0000-0002-9989-2381","https://orcid.org/0000-0003-0650-1175","https://orcid.org/0000-0002-0748-5026"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gang Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061826667","display_name":"Jiatao Lou","orcid":"https://orcid.org/0000-0001-8191-3255","observed_orcids":["https://orcid.org/0000-0001-8191-3255"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia-Tao Lou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108833270","display_name":"Wenqiang Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenqiang Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hypermethylation","display_name":"hypermethylation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/pan-cancer-biomarker","display_name":"pan-cancer biomarker","score":0.9660000205039978},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage-fluid","display_name":"bronchoalveolar lavage fluid","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tumor-screening","display_name":"cancer screening","score":0.6449999809265137},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7319999933242798},{"id":"https://openalex.org/keywords/histone-h4","display_name":"histone H4","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.8247824907302856},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6645668745040894},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6339802742004395},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6279447674751282},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.616665780544281},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5425193905830383},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47800981998443604},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4436129033565521},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43427175283432007},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3634800910949707},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33516979217529297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30668723583221436},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2997085452079773},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14306598901748657},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1307418942451477}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6511188.v1","doi":"https://doi.org/10.1158/0008-5472.c.6511188.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6511188.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6511188.v1","doi":"https://doi.org/10.1158/0008-5472.c.6511188.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6511188.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2977483297","https://openalex.org/W4361957971","https://openalex.org/W2269239459","https://openalex.org/W4232037809","https://openalex.org/W2087887510","https://openalex.org/W2571350358","https://openalex.org/W2284650234","https://openalex.org/W2314176182","https://openalex.org/W2495943536","https://openalex.org/W2347813157"],"abstract_inverted_index":{"Abstract":[0],"Lung":[1],"cancer":[2,20,39,55,105,134,144],"is":[3,13],"the":[4,14],"leading":[5],"cause":[6],"of":[7,34,74,104,150],"cancer-related":[8],"deaths":[9],"worldwide.":[10],"Cytologic":[11],"examination":[12],"current":[15],"\u201cgold":[16],"standard\u201d":[17],"for":[18,132,143],"lung":[19,38,54],"diagnosis,":[21],"however,":[22],"this":[23],"has":[24],"low":[25],"sensitivity.":[26],"Here,":[27],"we":[28],"identified":[29],"a":[30,117,140],"typical":[31],"methylation":[32,43,119],"signature":[33],"histone":[35],"genes":[36,152],"in":[37,64,85,100,125],"by":[40,48],"whole-genome":[41],"DNA":[42],"analysis,":[44],"which":[45,96,122],"was":[46,61,82,97],"validated":[47,99],"The":[49],"Cancer":[50],"Genome":[51],"Atlas":[52],"(TCGA)":[53],"cohort":[56],"(n":[57,93,106],"=":[58,94,107],"907)":[59],"and":[60,72,76,129,146],"further":[62,98],"confirmed":[63],"265":[65],"bronchoalveolar":[66],"lavage":[67],"fluid":[68],"samples":[69],"with":[70],"specificity":[71],"sensitivity":[73],"96.7%":[75],"87.0%,":[77],"respectively.":[78],"More":[79],"importantly,":[80],"HIST1H4F":[81,113],"universally":[83],"hypermethylated":[84],"all":[86],"17":[87],"tumor":[88],"types":[89,103],"from":[90],"TCGA":[91],"datasets":[92],"7,344),":[95],"nine":[101],"different":[102],"243).":[108],"These":[109,137],"results":[110],"demonstrate":[111],"that":[112,148],"can":[114],"function":[115],"as":[116],"universal-cancer-only":[118],"(UCOM)":[120],"marker,":[121],"may":[123],"aid":[124],"understanding":[126],"general":[127],"tumorigenesis":[128],"improve":[130],"screening":[131],"early":[133],"diagnosis.":[135],"Significance:":[136],"findings":[138],"identify":[139],"new":[141],"biomarker":[142],"detection":[145],"show":[147],"hypermethylation":[149],"histone-related":[151],"seems":[153],"to":[154],"persist":[155],"across":[156],"cancers.":[157]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
