{"id":"https://openalex.org/W4361844674","doi":"https://doi.org/10.1158/0008-5472.22390737","title":"Supplementary Figure 1 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer","display_name":"Supplementary Figure 1 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361844674","doi":"https://doi.org/10.1158/0008-5472.22390737"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22390737","doi":"https://doi.org/10.1158/0008-5472.22390737","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22390737","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22390737","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071898897","display_name":"Emily M. Fox","orcid":"https://orcid.org/0000-0002-0649-4414","observed_orcids":["https://orcid.org/0000-0002-0649-4414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily M. Fox","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080163243","display_name":"Todd W. Miller","orcid":"https://orcid.org/0000-0001-8912-2909","observed_orcids":["https://orcid.org/0000-0001-8912-2909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Todd W. Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089113899","display_name":"Justin Micah Balko","orcid":"https://orcid.org/0000-0002-4263-5974","observed_orcids":["https://orcid.org/0000-0002-4263-5974"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justin M. Balko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102744882","display_name":"Maria Gabriela Kuba","orcid":"https://orcid.org/0000-0003-0109-0231","observed_orcids":["https://orcid.org/0000-0003-0109-0231"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria G. Kuba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037252693","display_name":"Violeta M. Sanchez","orcid":"https://orcid.org/0000-0001-6639-9024","observed_orcids":["https://orcid.org/0000-0001-6639-9024","https://orcid.org/0000-0001-7967-8233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Violeta S\u00e1nchez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002988801","display_name":"R. Adam Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Adam Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100626214","display_name":"Shuying Liu","orcid":"https://orcid.org/0000-0001-5787-1163","observed_orcids":["https://orcid.org/0000-0001-5787-1163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuying Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073488441","display_name":"Ana Maria Gonzalez-Angulo","orcid":"https://orcid.org/0000-0002-9816-2707","observed_orcids":["https://orcid.org/0000-0002-9816-2707"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Mar\u00eda Gonz\u00e1lez-Angulo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357202","display_name":"Fei Ye","orcid":"https://orcid.org/0000-0001-6472-5076","observed_orcids":["https://orcid.org/0000-0001-6472-5076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fei Ye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062656698","display_name":"Yu Shyr","orcid":"https://orcid.org/0000-0003-2086-9670","observed_orcids":["https://orcid.org/0000-0003-2086-9670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Shyr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062023116","display_name":"H. Charles Manning","orcid":"https://orcid.org/0000-0002-2042-8800","observed_orcids":["https://orcid.org/0000-0002-2042-8800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Charles Manning","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040424020","display_name":"Elizabeth A. Buck","orcid":"https://orcid.org/0000-0002-6022-1871","observed_orcids":["https://orcid.org/0000-0002-6022-1871"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Buck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043946489","display_name":"Carlos L. Arteaga","orcid":"https://orcid.org/0000-0003-0870-9586","observed_orcids":["https://orcid.org/0000-0003-0870-9586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos L. Arteaga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.4115999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.4115999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.3292999863624573,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0722000002861023,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hormone-dependence","display_name":"hormone dependence","score":0.6549999713897705},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7910000085830688},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C54174078","wikidata":"https://www.wikidata.org/wiki/Q3197188","display_name":"Kinome","level":3,"score":0.9482558369636536},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6713811159133911},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.49999380111694336},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4831054210662842},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.47447875142097473},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4308466911315918},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.4254681468009949},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4165344834327698},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40560370683670044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3789287209510803},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35438334941864014},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3490574061870575},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34370243549346924},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29662221670150757},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2820320129394531},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20443511009216309},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18551909923553467},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1221843957901001},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.08495759963989258},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.22390737","doi":"https://doi.org/10.1158/0008-5472.22390737","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22390737","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.22390737.v1","doi":"https://doi.org/10.1158/0008-5472.22390737.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22390737.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_A_Kinome-Wide_Screen_Identifies_the_Insulin_IGF-I_Receptor_Pathway_as_a_Mechanism_of_Escape_from_Hormone_Dependence_in_Breast_Cancer/22390737/1/files/39836268.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22390737","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_A_Kinome-Wide_Screen_Identifies_the_Insulin_IGF-I_Receptor_Pathway_as_a_Mechanism_of_Escape_from_Hormone_Dependence_in_Breast_Cancer/22390737","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22390737","doi":"https://doi.org/10.1158/0008-5472.22390737","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22390737","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361844674.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2164541907","https://openalex.org/W4392679365","https://openalex.org/W1969740359","https://openalex.org/W2460869219","https://openalex.org/W7221164124","https://openalex.org/W7029341393","https://openalex.org/W2362881289","https://openalex.org/W2401439190","https://openalex.org/W4238669965","https://openalex.org/W1575040356"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"376K":[3]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-04-05T00:00:00"}