{"id":"https://openalex.org/W4361843673","doi":"https://doi.org/10.1158/0008-5472.c.6511230","title":"Data from Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis","display_name":"Data from Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361843673","doi":"https://doi.org/10.1158/0008-5472.c.6511230"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6511230","doi":"https://doi.org/10.1158/0008-5472.c.6511230","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6511230","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6511230","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067050108","display_name":"Yasuyuki Mizutani","orcid":"https://orcid.org/0000-0002-4363-3161","observed_orcids":["https://orcid.org/0000-0002-4363-3161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuyuki Mizutani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070753522","display_name":"Hiroki Kobayashi","orcid":"https://orcid.org/0000-0002-1717-4870","observed_orcids":["https://orcid.org/0000-0002-1717-4870","https://orcid.org/0000-0002-5337-2540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroki Kobayashi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1717-4870","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048443511","display_name":"Tadashi Iida","orcid":"https://orcid.org/0000-0001-5491-6012","observed_orcids":["https://orcid.org/0000-0001-5491-6012"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tadashi Iida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028812875","display_name":"Naoya Asai","orcid":"https://orcid.org/0000-0002-1930-0447","observed_orcids":["https://orcid.org/0000-0002-1930-0447"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoya Asai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044706381","display_name":"Atsushi Masamune","orcid":"https://orcid.org/0000-0001-7184-7282","observed_orcids":["https://orcid.org/0000-0001-7184-7282"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atsushi Masamune","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042365053","display_name":"Akitoshi Hara","orcid":"https://orcid.org/0000-0002-9369-3293","observed_orcids":["https://orcid.org/0000-0002-9369-3293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akitoshi Hara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019357990","display_name":"Nobutoshi Esaki","orcid":"https://orcid.org/0000-0002-6092-0736","observed_orcids":["https://orcid.org/0000-0002-6092-0736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobutoshi Esaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113436042","display_name":"Kaori Ushida","orcid":"https://orcid.org/0009-0006-9511-5733","observed_orcids":["https://orcid.org/0009-0006-9511-5733"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaori Ushida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066040234","display_name":"Shinji Mii","orcid":"https://orcid.org/0000-0001-8266-3235","observed_orcids":["https://orcid.org/0000-0001-8266-3235"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shinji Mii","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087833156","display_name":"Yukihiro Shiraki","orcid":"https://orcid.org/0000-0003-3666-0556","observed_orcids":["https://orcid.org/0000-0003-3666-0556"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukihiro Shiraki","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3666-0556","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034568552","display_name":"Kenju Ando","orcid":"https://orcid.org/0009-0007-6645-2674","observed_orcids":["https://orcid.org/0009-0007-6645-2674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenju Ando","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904439","display_name":"Liang Weng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liang Weng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086302856","display_name":"Seiichiro Ishihara","orcid":"https://orcid.org/0009-0000-6148-449X","observed_orcids":["https://orcid.org/0009-0000-6148-449X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seiichiro Ishihara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084992053","display_name":"Suzanne M. Ponik","orcid":"https://orcid.org/0000-0003-1367-4349","observed_orcids":["https://orcid.org/0000-0003-1367-4349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suzanne M. Ponik","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1367-4349","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065554744","display_name":"Matthew W. Conklin","orcid":"https://orcid.org/0000-0001-7087-4561","observed_orcids":["https://orcid.org/0000-0001-7087-4561"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew W. Conklin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077206064","display_name":"Hisashi Haga","orcid":"https://orcid.org/0000-0001-9464-6723","observed_orcids":["https://orcid.org/0000-0001-9464-6723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisashi Haga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054793137","display_name":"Arata Nagasaka","orcid":"https://orcid.org/0009-0008-4531-7470","observed_orcids":["https://orcid.org/0009-0008-4531-7470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arata Nagasaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013090856","display_name":"Takaki Miyata","orcid":"https://orcid.org/0000-0002-5952-0241","observed_orcids":["https://orcid.org/0000-0002-5952-0241"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takaki Miyata","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5952-0241","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020029139","display_name":"Makoto Matsuyama","orcid":"https://orcid.org/0000-0003-2606-059X","observed_orcids":["https://orcid.org/0000-0003-2606-059X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Makoto Matsuyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110698819","display_name":"Tomoe Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoe Kobayashi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1717-4870","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047606517","display_name":"Tsutomu Fujii","orcid":"https://orcid.org/0000-0003-0625-1911","observed_orcids":["https://orcid.org/0000-0003-0625-1911"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsutomu Fujii","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022391772","display_name":"Suguru Yamada","orcid":"https://orcid.org/0000-0001-9912-9119","observed_orcids":["https://orcid.org/0000-0001-9912-9119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suguru Yamada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060818759","display_name":"Junpei Yamaguchi","orcid":"https://orcid.org/0000-0002-5892-5271","observed_orcids":["https://orcid.org/0000-0002-5892-5271"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junpei Yamaguchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100687967","display_name":"Tongtong Wang","orcid":"https://orcid.org/0000-0002-8807-2441","observed_orcids":["https://orcid.org/0000-0002-8807-2441"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tongtong Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028417543","display_name":"Susan Lesley Woods","orcid":"https://orcid.org/0000-0002-8955-2017","observed_orcids":["https://orcid.org/0000-0002-8955-2017"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan L. Woods","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008826006","display_name":"Daniel L. Worthley","orcid":"https://orcid.org/0000-0003-0374-9124","observed_orcids":["https://orcid.org/0000-0003-0374-9124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Worthley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009811167","display_name":"Teppei Shimamura","orcid":"https://orcid.org/0000-0003-2994-872X","observed_orcids":["https://orcid.org/0000-0003-2994-872X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teppei Shimamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056500184","display_name":"Mitsuhiro Fujishiro","orcid":"https://orcid.org/0000-0002-4074-1140","observed_orcids":["https://orcid.org/0000-0002-4074-1140"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitsuhiro Fujishiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048728798","display_name":"Yoshiki Hirooka","orcid":"https://orcid.org/0000-0001-9639-7425","observed_orcids":["https://orcid.org/0000-0001-9639-7425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshiki Hirooka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016934524","display_name":"Atsushi Enomoto","orcid":"https://orcid.org/0000-0002-4149-6247","observed_orcids":["https://orcid.org/0000-0002-4149-6247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atsushi Enomoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048038268","display_name":"Masahide Takahashi","orcid":"https://orcid.org/0000-0002-2803-2683","observed_orcids":["https://orcid.org/0000-0002-2803-2683"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masahide Takahashi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2803-2683","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.972000002861023},{"id":"https://openalex.org/keywords/pancreatic-stellate-cells","display_name":"pancreatic stellate cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9269999861717224},{"id":"https://openalex.org/keywords/caf-heterogeneity","display_name":"CAF heterogeneity","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5109999775886536},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.7409999966621399},{"id":"https://openalex.org/keywords/gpi-anchored-proteins","display_name":"GPI-anchored proteins","score":0.8080000281333923},{"id":"https://openalex.org/keywords/patient-outcomes","display_name":"patient outcomes","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C2909706936","wikidata":"https://www.wikidata.org/wiki/Q42417562","display_name":"Cancer-Associated Fibroblasts","level":4,"score":0.7315658330917358},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7042976021766663},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6650571227073669},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6393693685531616},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.596551775932312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5710958242416382},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5661311745643616},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.48765552043914795},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.4822998046875},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.4226270318031311},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4087929427623749},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3747755289077759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23368126153945923},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2190350890159607},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.1733013391494751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.164507657289505},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1115034818649292},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6511230","doi":"https://doi.org/10.1158/0008-5472.c.6511230","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6511230","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6511230","doi":"https://doi.org/10.1158/0008-5472.c.6511230","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6511230","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2969959193","https://openalex.org/W2995902966","https://openalex.org/W2955461363","https://openalex.org/W3175079523","https://openalex.org/W4390915194","https://openalex.org/W4223450969","https://openalex.org/W4206502761","https://openalex.org/W4284880966","https://openalex.org/W7127065078","https://openalex.org/W3202445277"],"abstract_inverted_index":{"Abstract":[0],"Cancer-associated":[1],"fibroblasts":[2,261],"(CAF)":[3],"constitute":[4],"a":[5,72,77,96,140,157,164,204,223,242,257],"major":[6],"component":[7],"of":[8,34,54,59,62,79,98,109,118,147,154,163,173,180,244,259],"the":[9,52,60,116,168,178,236],"tumor":[10,133,169],"microenvironment.":[11],"Recent":[12],"observations":[13],"in":[14,100,139,151,156,175,216,228],"genetically":[15],"engineered":[16],"mouse":[17,142,229],"models":[18],"and":[19,41,83,253],"clinical":[20],"studies":[21],"have":[22,49],"suggested":[23],"that":[24,36,70,75,94,115,186,196,239,246,262],"there":[25],"may":[26],"exist":[27],"at":[28],"least":[29],"two":[30],"functionally":[31,254],"different":[32],"populations":[33],"CAFs,":[35],"is,":[37],"cancer-promoting":[38],"CAFs":[39,43,99,120,149,176,195],"(pCAF)":[40],"cancer-restraining":[42],"(rCAF).":[44],"Although":[45],"various":[46],"pCAF":[47],"markers":[48],"been":[50],"identified,":[51],"identity":[53],"rCAFs":[55,245],"remains":[56],"unknown":[57],"because":[58],"lack":[61],"rCAF-specific":[63],"marker(s).":[64],"In":[65,105],"this":[66],"study,":[67],"we":[68],"found":[69],"Meflin,":[71,202],"glycosylphosphatidylinositol-anchored":[73],"protein":[74],"is":[76,88,241],"marker":[78,243],"mesenchymal":[80],"stromal/stem":[81],"cells":[82,93,188],"maintains":[84],"their":[85],"undifferentiated":[86],"state,":[87],"expressed":[89],"by":[90],"pancreatic":[91,101],"stellate":[92],"are":[95,197],"source":[97],"ductal":[102],"adenocarcinoma":[103],"(PDAC).":[104],"situ":[106],"hybridization":[107],"analysis":[108],"71":[110],"human":[111,231],"PDAC":[112,141,232,248],"tissues":[113],"revealed":[114,185],"infiltration":[117],"Meflin-positive":[119,148,187],"correlated":[121],"with":[122,135],"favorable":[123],"patient":[124],"outcome.":[125],"Consistent":[126],"herewith,":[127],"Meflin":[128,174,210,240,251],"deficiency":[129,211],"led":[130],"to":[131,191,256],"significant":[132],"progression":[134],"poorly":[136],"differentiated":[137],"histology":[138],"model.":[143,160],"Similarly,":[144],"genetic":[145],"ablation":[146],"resulted":[150,215],"poor":[152],"differentiation":[153],"tumors":[155],"syngeneic":[158],"transplantation":[159],"Conversely,":[161],"delivery":[162],"Meflin-expressing":[165],"lentivirus":[166],"into":[167],"stroma":[170],"or":[171,199,212,230],"overexpression":[172],"suppressed":[177],"growth":[179],"xenograft":[181],"tumors.":[182],"Lineage":[183],"tracing":[184],"gave":[189],"rise":[190],"\u03b1-smooth":[192],"muscle":[193],"actin-positive":[194],"positive":[198],"negative":[200],"for":[201,206,225],"suggesting":[203],"mechanism":[205],"generating":[207],"CAF":[208],"heterogeneity.":[209],"low":[213],"expression":[214],"straightened":[217],"stromal":[218],"collagen":[219],"fibers,":[220],"which":[221],"represent":[222],"signature":[224],"aggressive":[226],"tumors,":[227],"tissues,":[233],"respectively.":[234],"Together,":[235],"data":[237],"suggest":[238],"suppress":[247],"progression.":[249],"Significance:":[250],"marks":[252],"contributes":[255],"subset":[258],"cancer-associated":[260],"exert":[263],"antitumoral":[264],"effects.":[265]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2023-04-05T00:00:00"}