{"id":"https://openalex.org/W4361842970","doi":"https://doi.org/10.1158/0008-5472.22423679","title":"Supplementary Data from A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma","display_name":"Supplementary Data from A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361842970","doi":"https://doi.org/10.1158/0008-5472.22423679"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22423679","doi":"https://doi.org/10.1158/0008-5472.22423679","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22423679","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22423679","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052928890","display_name":"Tikvah K. Hayes","orcid":"https://orcid.org/0000-0003-0008-5246","observed_orcids":["https://orcid.org/0000-0003-0008-5246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tikvah K. Hayes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904471","display_name":"Flora Luo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Flora Luo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083324690","display_name":"Ofir Cohen","orcid":"https://orcid.org/0000-0002-0043-6838","observed_orcids":["https://orcid.org/0000-0002-0043-6838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ofir Cohen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060463684","display_name":"Amy B. Goodale","orcid":"https://orcid.org/0000-0003-4294-5777","observed_orcids":["https://orcid.org/0000-0003-4294-5777"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy B. Goodale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031035835","display_name":"Yenarae Lee","orcid":"https://orcid.org/0009-0002-3777-343X","observed_orcids":["https://orcid.org/0009-0002-3777-343X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yenarae Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005268578","display_name":"Sasha Pantel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sasha Pantel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075861555","display_name":"Mukta Bagul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mukta Bagul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000745052","display_name":"Federica Piccioni","orcid":"https://orcid.org/0000-0003-1210-3210","observed_orcids":["https://orcid.org/0000-0003-1210-3210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Federica Piccioni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086771961","display_name":"David E. Root","orcid":"https://orcid.org/0000-0001-5122-861X","observed_orcids":["https://orcid.org/0000-0001-5122-861X","https://orcid.org/0000-0003-0096-4830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David E. Root","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5122-861X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055048393","display_name":"Levi A. Garraway","orcid":"https://orcid.org/0000-0003-3739-0471","observed_orcids":["https://orcid.org/0000-0003-3739-0471"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Levi A. Garraway","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056373767","display_name":"Matthew M. Meyerson","orcid":"https://orcid.org/0000-0002-9133-8108","observed_orcids":["https://orcid.org/0000-0002-9133-8108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Meyerson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022484206","display_name":"Cory M. Johannessen","orcid":"https://orcid.org/0000-0002-2618-1036","observed_orcids":["https://orcid.org/0000-0002-2618-1036"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cory M. Johannessen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2618-1036","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nras-mutant-melanoma","display_name":"NRAS-mutant melanoma","score":0.925000011920929},{"id":"https://openalex.org/keywords/mek1-2-inhibition","display_name":"MEK1/2 inhibition","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cdk4-6-inhibition","display_name":"CDK4/6 inhibition","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9620000123977661},{"id":"https://openalex.org/keywords/functional-genomic-screens","display_name":"functional genomic screens","score":0.44999998807907104},{"id":"https://openalex.org/keywords/crispr-screening","display_name":"CRISPR screen","score":0.8500000238418579},{"id":"https://openalex.org/keywords/enrichment-score","display_name":"enrichment score","score":0.6230000257492065},{"id":"https://openalex.org/keywords/resistance-genes","display_name":"resistance genes","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.9007024168968201},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.6561958193778992},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6474941968917847},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.46293726563453674},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4046930968761444},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.3880111575126648},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38767021894454956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38627249002456665},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3397732675075531},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2992417514324188},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1092950701713562},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08713051676750183}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.22423679","doi":"https://doi.org/10.1158/0008-5472.22423679","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22423679","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.22423679.v1","doi":"https://doi.org/10.1158/0008-5472.22423679.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22423679.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22423679","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Data_from_A_Functional_Landscape_of_Resistance_to_MEK1_2_and_CDK4_6_Inhibition_in_NRAS-Mutant_Melanoma/22423679","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22423679","doi":"https://doi.org/10.1158/0008-5472.22423679","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22423679","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361842968","https://openalex.org/W2918594924","https://openalex.org/W2975506762","https://openalex.org/W4417237615","https://openalex.org/W6910561812","https://openalex.org/W4200436752","https://openalex.org/W6902377202","https://openalex.org/W4282918986","https://openalex.org/W4362528975","https://openalex.org/W7056843444"],"abstract_inverted_index":{"Supplementary":[0],"Table":[1],"1":[2],"contains":[3],"the":[4,8,12],"enrichment":[5],"scores":[6],"for":[7],"candidates":[9],"from":[10],"both":[11],"ORF":[13],"and":[14],"CRISPR":[15],"screens":[16]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-04-05T00:00:00"}
