{"id":"https://openalex.org/W4361832297","doi":"https://doi.org/10.1158/0008-5472.22388106","title":"Supplementary Methods from The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models","display_name":"Supplementary Methods from The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361832297","doi":"https://doi.org/10.1158/0008-5472.22388106"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22388106","doi":"https://doi.org/10.1158/0008-5472.22388106","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22388106","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Methods_from_The_Dual_EGFR_HER2_Inhibitor_Lapatinib_Synergistically_Enhances_the_Antitumor_Activity_of_the_Histone_Deacetylase_Inhibitor_Panobinostat_in_Colorectal_Cancer_Models/22388106/1/files/39833586.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Methods_from_The_Dual_EGFR_HER2_Inhibitor_Lapatinib_Synergistically_Enhances_the_Antitumor_Activity_of_the_Histone_Deacetylase_Inhibitor_Panobinostat_in_Colorectal_Cancer_Models/22388106/1/files/39833586.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081238740","display_name":"Melissa J. LaBonte","orcid":"https://orcid.org/0000-0002-0354-413X","observed_orcids":["https://orcid.org/0000-0002-0354-413X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa J. LaBonte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967213","display_name":"Peter M. Wilson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter M. Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051634947","display_name":"Will Fazzone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Will Fazzone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jared Russell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jared Russell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002462952","display_name":"Stan G. Louie","orcid":"https://orcid.org/0000-0001-5941-6690","observed_orcids":["https://orcid.org/0000-0001-5941-6690"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stan G. Louie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013744957","display_name":"Anthony B. El-Khoueiry","orcid":"https://orcid.org/0000-0002-9053-3841","observed_orcids":["https://orcid.org/0000-0002-9053-3841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony El-Khoueiry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045441776","display_name":"Heinz\u2010Josef Lenz","orcid":"https://orcid.org/0000-0003-2178-9568","observed_orcids":["https://orcid.org/0000-0003-2178-9568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heinz-Josef Lenz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085279591","display_name":"Robert D. Ladner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert D. Ladner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lapatinib","display_name":"lapatinib","score":1.0},{"id":"https://openalex.org/keywords/panobinostat","display_name":"panobinostat","score":0.9980000257492065},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.8849999904632568},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.8379999995231628},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6710000038146973},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C2780225316","wikidata":"https://www.wikidata.org/wiki/Q7131441","display_name":"Panobinostat","level":5,"score":0.9769506454467773},{"id":"https://openalex.org/C2777329042","wikidata":"https://www.wikidata.org/wiki/Q420323","display_name":"Lapatinib","level":5,"score":0.8705124855041504},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.8387545943260193},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5861631631851196},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.5261325836181641},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.486741304397583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4601171314716339},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38905611634254456},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.366097629070282},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3193545639514923},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.24274882674217224},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.23731711506843567},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18692922592163086},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.17603856325149536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.22388106","doi":"https://doi.org/10.1158/0008-5472.22388106","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22388106","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Methods_from_The_Dual_EGFR_HER2_Inhibitor_Lapatinib_Synergistically_Enhances_the_Antitumor_Activity_of_the_Histone_Deacetylase_Inhibitor_Panobinostat_in_Colorectal_Cancer_Models/22388106/1/files/39833586.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.22388106.v1","doi":"https://doi.org/10.1158/0008-5472.22388106.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22388106.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22388106","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Methods_from_The_Dual_EGFR_HER2_Inhibitor_Lapatinib_Synergistically_Enhances_the_Antitumor_Activity_of_the_Histone_Deacetylase_Inhibitor_Panobinostat_in_Colorectal_Cancer_Models/22388106","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22388106","doi":"https://doi.org/10.1158/0008-5472.22388106","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22388106","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Methods_from_The_Dual_EGFR_HER2_Inhibitor_Lapatinib_Synergistically_Enhances_the_Antitumor_Activity_of_the_Histone_Deacetylase_Inhibitor_Panobinostat_in_Colorectal_Cancer_Models/22388106/1/files/39833586.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361832297.pdf","grobid_xml":"https://content.openalex.org/works/W4361832297.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W2023237279","https://openalex.org/W2044497301","https://openalex.org/W2077945404","https://openalex.org/W4405993572"],"related_works":["https://openalex.org/W2145953198","https://openalex.org/W4392678817","https://openalex.org/W1991944575","https://openalex.org/W7168342294","https://openalex.org/W2042976627","https://openalex.org/W2715730378","https://openalex.org/W1681190610","https://openalex.org/W2227073681","https://openalex.org/W2084930534","https://openalex.org/W6976865102"],"abstract_inverted_index":{"Supplementary":[0],"Methods":[1],"from":[2],"The":[3],"Dual":[4],"EGFR/HER2":[5],"Inhibitor":[6,17],"Lapatinib":[7],"Synergistically":[8],"Enhances":[9],"the":[10,14],"Antitumor":[11],"Activity":[12],"of":[13],"Histone":[15],"Deacetylase":[16],"Panobinostat":[18],"in":[19],"Colorectal":[20],"Cancer":[21],"Models":[22]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}