{"id":"https://openalex.org/W4361827407","doi":"https://doi.org/10.1158/0008-5472.22414761","title":"Figure S8 from \u03b2-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy","display_name":"Figure S8 from \u03b2-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361827407","doi":"https://doi.org/10.1158/0008-5472.22414761"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22414761","doi":"https://doi.org/10.1158/0008-5472.22414761","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22414761","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22414761","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078984239","display_name":"Mark J. Bucsek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark J. Bucsek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079666362","display_name":"Guanxi Qiao","orcid":"https://orcid.org/0000-0002-7340-7077","observed_orcids":["https://orcid.org/0000-0002-7340-7077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guanxi Qiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036102637","display_name":"Cameron R. MacDonald","orcid":"https://orcid.org/0000-0002-7402-7113","observed_orcids":["https://orcid.org/0000-0002-7402-7113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cameron R. MacDonald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016454018","display_name":"Thejaswini Giridharan","orcid":"https://orcid.org/0000-0003-0512-577X","observed_orcids":["https://orcid.org/0000-0003-0512-577X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thejaswini Giridharan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102735317","display_name":"Lauren Evans","orcid":"https://orcid.org/0000-0002-8268-7031","observed_orcids":["https://orcid.org/0000-0002-8268-7031","https://orcid.org/0000-0002-9874-9241"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lauren Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080242259","display_name":"Brian Niedzwecki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Niedzwecki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100782472","display_name":"Haichao Liu","orcid":"https://orcid.org/0000-0001-6866-1284","observed_orcids":["https://orcid.org/0000-0001-6866-1284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haichao Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019688706","display_name":"Kathleen M. Kokolus","orcid":"https://orcid.org/0000-0002-9088-5409","observed_orcids":["https://orcid.org/0000-0002-9088-5409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathleen M. Kokolus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066978332","display_name":"Jason W.\u2010L. Eng","orcid":"https://orcid.org/0000-0002-8219-2290","observed_orcids":["https://orcid.org/0000-0002-8219-2290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason W.-L. Eng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058177760","display_name":"Michelle Nicole Messmer","orcid":"https://orcid.org/0000-0002-7597-8615","observed_orcids":["https://orcid.org/0000-0002-7597-8615"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle N. Messmer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011054139","display_name":"Kristopher M. Attwood","orcid":"https://orcid.org/0000-0002-7229-5472","observed_orcids":["https://orcid.org/0000-0002-7229-5472","https://orcid.org/0009-0003-3874-1293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristopher Attwood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058401562","display_name":"Scott I. Abrams","orcid":"https://orcid.org/0000-0002-8742-4708","observed_orcids":["https://orcid.org/0000-0002-8742-4708"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott I. Abrams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085199635","display_name":"Bonnie Lee Hylander","orcid":"https://orcid.org/0000-0002-0836-1893","observed_orcids":["https://orcid.org/0000-0002-0836-1893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bonnie L. Hylander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029344793","display_name":"Elizabeth A. Repasky","orcid":"https://orcid.org/0000-0002-9554-4152","observed_orcids":["https://orcid.org/0000-0002-9554-4152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth A. Repasky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-signaling","display_name":"beta-adrenergic signaling","score":0.9549999833106995},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/anti-pd-1-antibody","display_name":"anti-PD-1","score":0.8069999814033508},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8299999833106995},{"id":"https://openalex.org/keywords/4t1-tumor","display_name":"4T1 tumor","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tumor-bearing-mice","display_name":"tumor-bearing mice","score":0.5870000123977661},{"id":"https://openalex.org/keywords/effector-t-cells","display_name":"effector T cells","score":0.7229999899864197},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.7344722747802734},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6936237812042236},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5898345112800598},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4863513112068176},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4857945442199707},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4626880884170532},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41740691661834717},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38914498686790466},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38294902443885803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2975471019744873},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2920054495334625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27118968963623047},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24286440014839172},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12689045071601868},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11398878693580627},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.09916135668754578},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08422401547431946}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.22414761","doi":"https://doi.org/10.1158/0008-5472.22414761","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22414761","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.22414761.v1","doi":"https://doi.org/10.1158/0008-5472.22414761.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22414761.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22414761","doi":"https://doi.org/10.1158/0008-5472.22414761","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22414761","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362421796","https://openalex.org/W4362461481","https://openalex.org/W4362348241","https://openalex.org/W4362421807","https://openalex.org/W4362348238","https://openalex.org/W4362446375","https://openalex.org/W4361820570","https://openalex.org/W4361824101","https://openalex.org/W2748524892","https://openalex.org/W4313373579"],"abstract_inverted_index":{"This":[0],"figure":[1],"shows":[2],"that":[3],"similar":[4],"to":[5],"our":[6],"observations":[7],"in":[8,34],"mice":[9,17],"treated":[10],"with":[11,18],"only":[12],"propranolol,":[13],"treating":[14],"4T1":[15],"tumor-bearing":[16],"anti-PD-1":[19],"and":[20],"propranolol":[21],"does":[22],"not":[23],"increase":[24],"the":[25],"frequency":[26],"or":[27],"relative":[28],"number":[29],"of":[30],"CD8+":[31],"T":[32],"cells":[33],"tumors.":[35]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
