{"id":"https://openalex.org/W4361827112","doi":"https://doi.org/10.1158/0008-5472.c.6508269","title":"Data from Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors","display_name":"Data from Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361827112","doi":"https://doi.org/10.1158/0008-5472.c.6508269"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6508269","doi":"https://doi.org/10.1158/0008-5472.c.6508269","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6508269","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6508269","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110967393","display_name":"Theresia R. Kress","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theresia R. Kress","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036897614","display_name":"Paola Pellanda","orcid":"https://orcid.org/0000-0002-7494-8334","observed_orcids":["https://orcid.org/0000-0002-7494-8334"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola Pellanda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009698399","display_name":"Luca Pellegrinet","orcid":"https://orcid.org/0000-0003-2081-8531","observed_orcids":["https://orcid.org/0000-0003-2081-8531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luca Pellegrinet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085896954","display_name":"Valerio Bianchi","orcid":"https://orcid.org/0000-0001-9025-7923","observed_orcids":["https://orcid.org/0000-0001-9025-7923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valerio Bianchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015568698","display_name":"Paola Nicoli","orcid":"https://orcid.org/0000-0002-6284-1839","observed_orcids":["https://orcid.org/0000-0002-6284-1839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola Nicoli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073541194","display_name":"Mirko Doni","orcid":"https://orcid.org/0000-0001-7099-2701","observed_orcids":["https://orcid.org/0000-0001-7099-2701"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mirko Doni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090326151","display_name":"Camilla Recordati","orcid":"https://orcid.org/0000-0002-7172-9662","observed_orcids":["https://orcid.org/0000-0002-7172-9662"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camilla Recordati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058937103","display_name":"Salvatore Bianchi","orcid":"https://orcid.org/0009-0009-7383-9732","observed_orcids":["https://orcid.org/0009-0009-7383-9732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salvatore Bianchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026698342","display_name":"Luca Rotta","orcid":"https://orcid.org/0000-0001-6915-1120","observed_orcids":["https://orcid.org/0000-0001-6915-1120"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luca Rotta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030754377","display_name":"Thelma Capra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thelma Capra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071842065","display_name":"Micol Rav\u00e0","orcid":"https://orcid.org/0000-0001-7606-8368","observed_orcids":["https://orcid.org/0000-0001-7606-8368"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Micol Rav\u00e0","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073844034","display_name":"Alessandro Verrecchia","orcid":"https://orcid.org/0000-0002-8596-6650","observed_orcids":["https://orcid.org/0000-0002-8596-6650"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandro Verrecchia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016391982","display_name":"Enrico Radaelli","orcid":"https://orcid.org/0000-0002-2885-0221","observed_orcids":["https://orcid.org/0000-0002-2885-0221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enrico Radaelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043387899","display_name":"Trevor D. Littlewood","orcid":"https://orcid.org/0000-0003-3475-1462","observed_orcids":["https://orcid.org/0000-0003-3475-1462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Trevor D. Littlewood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042437588","display_name":"G\u00e9rard I. Evan","orcid":"https://orcid.org/0000-0003-0412-1216","observed_orcids":["https://orcid.org/0000-0003-0412-1216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerard I. Evan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036162019","display_name":"Bruno B. Amati","orcid":"https://orcid.org/0000-0002-2958-1799","observed_orcids":["https://orcid.org/0000-0002-2958-1799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Amati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.32760000228881836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.32760000228881836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.18440000712871552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.984000027179718},{"id":"https://openalex.org/keywords/oncogene-addiction","display_name":"oncogene addiction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.625},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.968999981880188},{"id":"https://openalex.org/keywords/hepatoblastoma","display_name":"hepatoblastoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/transcriptional-programs","display_name":"transcriptional programs","score":0.6269999742507935},{"id":"https://openalex.org/keywords/miz1","display_name":"Miz-1","score":0.7080000042915344},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.5879999995231628},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5809999704360962},{"id":"https://openalex.org/keywords/chromatin-immunoprecipitation","display_name":"chromatin immunoprecipitation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tumor-maintenance","display_name":"tumor maintenance","score":0.6150000095367432},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6466567516326904},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6291873455047607},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.5916441679000854},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5723360180854797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5439398884773254},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4761876165866852},{"id":"https://openalex.org/C2777956278","wikidata":"https://www.wikidata.org/wiki/Q14906753","display_name":"N-Myc","level":5,"score":0.46861299872398376},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.461507111787796},{"id":"https://openalex.org/C2776304256","wikidata":"https://www.wikidata.org/wiki/Q1607658","display_name":"Hepatoblastoma","level":2,"score":0.42651939392089844},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.41384726762771606},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4088890552520752},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3602672517299652},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3325948715209961},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18288454413414001},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.16537147760391235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14485099911689758},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.13815349340438843},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.09820759296417236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08204087615013123},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.07176318764686584},{"id":"https://openalex.org/C2779102060","wikidata":"https://www.wikidata.org/wiki/Q1124606","display_name":"Ganglioneuroma","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.c.6508269","doi":"https://doi.org/10.1158/0008-5472.c.6508269","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6508269","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.c.6508269.v1","doi":"https://doi.org/10.1158/0008-5472.c.6508269.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6508269.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6508269","doi":"https://doi.org/10.1158/0008-5472.c.6508269","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6508269","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2339244615","https://openalex.org/W2288922715","https://openalex.org/W2313546999","https://openalex.org/W2004071564","https://openalex.org/W2105613536","https://openalex.org/W2048647140","https://openalex.org/W2439543196","https://openalex.org/W2103667298","https://openalex.org/W4361265347","https://openalex.org/W2328710346"],"abstract_inverted_index":{"Abstract":[0],"Tumors":[1],"driven":[2,38],"by":[3,39],"activation":[4,120],"of":[5,35,84,123,126,133,145,157],"the":[6,15,99,107,118,153,173],"transcription":[7],"factor":[8],"MYC":[9,23,71,93,114],"generally":[10],"show":[11,77],"oncogene":[12,108],"addiction.":[13],"However,":[14],"gene":[16,49],"expression":[17,50,72],"programs":[18],"that":[19,78,113],"depend":[20],"upon":[21],"sustained":[22],"activity":[24],"remain":[25],"unknown.":[26],"In":[27],"this":[28],"study,":[29],"we":[30],"employed":[31],"a":[32,40,92,158,163,169],"mouse":[33],"model":[34],"liver":[36,85],"carcinoma":[37,166],"reversible":[41],"tet-MYC":[42],"transgene,":[43],"combined":[44],"with":[45,98],"chromatin":[46],"immunoprecipitation":[47],"and":[48,64,81,121,140,167],"profiling":[51],"to":[52,96,171,177],"identify":[53],"MYC-dependent":[54,159],"regulatory":[55],"events.":[56],"As":[57],"previously":[58],"reported,":[59],"MYC-expressing":[60],"mice":[61,90],"exhibited":[62],"hepatoblastoma-":[63],"hepatocellular":[65],"carcinoma\u2013like":[66],"tumors,":[67],"which":[68],"regressed":[69],"when":[70],"was":[73,115],"suppressed.":[74],"We":[75],"further":[76],"cellular":[79],"transformation,":[80],"thus":[82],"initiation":[83],"tumorigenesis,":[86],"were":[87],"impaired":[88],"in":[89,109,162],"harboring":[91],"mutant":[94],"unable":[95],"associate":[97],"corepressor":[100],"protein":[101],"MIZ1":[102],"(ZBTB17).":[103],"Notably,":[104],"switching":[105],"off":[106],"advanced":[110],"carcinomas":[111],"revealed":[112],"required":[116],"for":[117],"continuous":[119],"repression":[122],"distinct":[124],"sets":[125],"genes,":[127],"constituting":[128],"no":[129],"more":[130],"than":[131],"half":[132],"all":[134,146],"genes":[135],"deregulated":[136],"during":[137],"tumor":[138,179],"progression":[139],"an":[141],"even":[142],"smaller":[143],"subset":[144],"MYC-bound":[147],"genes.":[148],"Altogether,":[149],"our":[150],"data":[151],"provide":[152],"first":[154],"detailed":[155],"analysis":[156],"transcriptional":[160],"program":[161],"fully":[164],"developed":[165],"offer":[168],"guide":[170],"identifying":[172],"critical":[174],"effectors":[175],"contributing":[176],"MYC-driven":[178],"maintenance.":[180],"Cancer":[181],"Res;":[182],"76(12);":[183],"3463\u201372.":[184],"\u00a92016":[185],"AACR.":[186]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}