{"id":"https://openalex.org/W4361826558","doi":"https://doi.org/10.1158/0008-5472.c.6499982","title":"Data from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription","display_name":"Data from A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361826558","doi":"https://doi.org/10.1158/0008-5472.c.6499982"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6499982","doi":"https://doi.org/10.1158/0008-5472.c.6499982","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6499982","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6499982","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062642279","display_name":"Kenneth Ewan","orcid":"https://orcid.org/0000-0001-6622-9009","observed_orcids":["https://orcid.org/0000-0001-6622-9009"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth Ewan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003150024","display_name":"Bo\u017cena Paj\u0105k","orcid":"https://orcid.org/0000-0001-6767-3590","observed_orcids":["https://orcid.org/0000-0001-6767-3590"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bo\u017cena Paj\u0105k","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084313119","display_name":"Mark Stubbs","orcid":"https://orcid.org/0000-0001-7855-9435","observed_orcids":["https://orcid.org/0000-0001-7855-9435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Stubbs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114239692","display_name":"Helen Todd","orcid":"https://orcid.org/0000-0002-7983-2752","observed_orcids":["https://orcid.org/0000-0002-7983-2752"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen Todd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027264441","display_name":"Olivier R. Barbeau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olivier Barbeau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018587562","display_name":"Camilo E. Quevedo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camilo Quevedo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009037177","display_name":"Hannah F. Botfield","orcid":"https://orcid.org/0000-0003-4564-0282","observed_orcids":["https://orcid.org/0000-0003-4564-0282"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hannah Botfield","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057686273","display_name":"Rodrigo Young","orcid":"https://orcid.org/0000-0001-5765-197X","observed_orcids":["https://orcid.org/0000-0001-5765-197X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodrigo Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059545579","display_name":"Ruth R. Ruddle","orcid":"https://orcid.org/0000-0003-0025-8872","observed_orcids":["https://orcid.org/0000-0003-0025-8872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruth Ruddle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054191243","display_name":"Lee J. Samuel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lee Samuel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025588631","display_name":"Alysia Battersby","orcid":"https://orcid.org/0000-0002-0715-6935","observed_orcids":["https://orcid.org/0000-0002-0715-6935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alysia Battersby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058014829","display_name":"Florence I. Raynaud","orcid":"https://orcid.org/0000-0003-0957-6279","observed_orcids":["https://orcid.org/0000-0003-0957-6279"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florence Raynaud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063313898","display_name":"Nicholas Brian Allen","orcid":"https://orcid.org/0000-0002-1086-6639","observed_orcids":["https://orcid.org/0000-0002-1086-6639"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas Allen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057061873","display_name":"Stephen W. Wilson","orcid":"https://orcid.org/0000-0002-8557-5940","observed_orcids":["https://orcid.org/0000-0002-8557-5940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022172613","display_name":"Branko Latinkic","orcid":"https://orcid.org/0000-0003-4952-123X","observed_orcids":["https://orcid.org/0000-0003-4952-123X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Branko Latinkic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003965204","display_name":"Paul Workman","orcid":"https://orcid.org/0000-0003-1659-3034","observed_orcids":["https://orcid.org/0000-0003-1659-3034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Workman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041900322","display_name":"Edward McDonald","orcid":"https://orcid.org/0009-0009-5965-3018","observed_orcids":["https://orcid.org/0009-0009-5965-3018"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edward McDonald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055979646","display_name":"Julian Blagg","orcid":"https://orcid.org/0000-0002-7409-0323","observed_orcids":["https://orcid.org/0000-0002-7409-0323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julian Blagg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006946698","display_name":"Wynne Aherne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wynne Aherne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003639137","display_name":"Trevor C. Dale","orcid":"https://orcid.org/0000-0002-4880-9963","observed_orcids":["https://orcid.org/0000-0002-4880-9963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Trevor Dale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/beta-catenin-degradation","display_name":"\u03b2-catenin degradation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3","display_name":"glycogen synthase kinase-3","score":0.8870000243186951},{"id":"https://openalex.org/keywords/chemical-library-screening","display_name":"chemical library screening","score":0.640999972820282},{"id":"https://openalex.org/keywords/deconvolution","display_name":"deconvolution","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cancer-therapeutics","display_name":"cancer therapeutics","score":0.6320000290870667},{"id":"https://openalex.org/keywords/apc-mutation","display_name":"APC mutation","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.9506188631057739},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.5279221534729004},{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.5037094950675964},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5003652572631836},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4727174639701843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4580402076244354},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4484559893608093},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4391290545463562},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4307922124862671},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4013747572898865},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3817087411880493},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34035736322402954},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29786252975463867},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2304181456565857},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.c.6499982","doi":"https://doi.org/10.1158/0008-5472.c.6499982","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6499982","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.c.6499982.v1","doi":"https://doi.org/10.1158/0008-5472.c.6499982.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6499982.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6499982","doi":"https://doi.org/10.1158/0008-5472.c.6499982","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6499982","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2101859333","https://openalex.org/W7096105847","https://openalex.org/W2077579863","https://openalex.org/W112575187","https://openalex.org/W2740339371","https://openalex.org/W2199613542","https://openalex.org/W2999676366","https://openalex.org/W92974609","https://openalex.org/W2280028057","https://openalex.org/W7099938519"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"Wnt":[2,25,79,115],"signaling":[3,26,116],"pathway":[4,49],"is":[5],"frequently":[6],"deregulated":[7],"in":[8,13,43],"cancer":[9,74],"due":[10],"to":[11,65,88,110,125],"mutations":[12],"genes":[14],"encoding":[15],"APC,":[16],"\u03b2-catenin,":[17],"and":[18],"axin.":[19],"To":[20],"identify":[21,111],"small-molecule":[22,112],"inhibitors":[23,113],"of":[24,47,55,60,82,91,114,122],"as":[27],"potential":[28],"therapeutics,":[29],"a":[30,37,98,107],"diverse":[31],"chemical":[32],"library":[33],"was":[34,50,63],"screened":[35],"using":[36],"transcription":[38],"factor":[39],"reporter":[40],"cell":[41,75],"line":[42],"which":[44],"the":[45,48,53,83,86,120],"activity":[46],"induced":[51],"at":[52],"level":[54],"Disheveled":[56],"protein.":[57],"A":[58],"series":[59,70],"deconvolution":[61],"studies":[62],"used":[64],"focus":[66],"on":[67],"three":[68],"compound":[69],"that":[71,93,117],"selectively":[72],"killed":[73],"lines":[76],"with":[77,128],"constitutive":[78],"signaling.":[80],"Activities":[81],"compounds":[84],"included":[85],"ability":[87],"induce":[89],"degradation":[90],"\u03b2-catenin":[92],"had":[94],"been":[95],"stabilized":[96],"by":[97],"glycogen":[99],"synthase":[100],"kinase-3":[101],"(GSK-3)":[102],"inhibitor.":[103],"This":[104],"screen":[105],"illustrates":[106],"practical":[108],"approach":[109],"can":[118],"seed":[119],"development":[121],"agents":[123],"suitable":[124],"treat":[126],"patients":[127],"Wnt-dependent":[129],"tumors.":[130],"Cancer":[131],"Res;":[132],"70(14);":[133],"5963\u201373.":[134],"\u00a92010":[135],"AACR.":[136]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-05T00:00:00"}
