{"id":"https://openalex.org/W4361825136","doi":"https://doi.org/10.1158/0008-5472.c.6512463.v1","title":"Data from A Wnt-Induced Phenotypic Switch in Cancer-Associated Fibroblasts Inhibits EMT in Colorectal Cancer","display_name":"Data from A Wnt-Induced Phenotypic Switch in Cancer-Associated Fibroblasts Inhibits EMT in Colorectal Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361825136","doi":"https://doi.org/10.1158/0008-5472.c.6512463.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6512463.v1","doi":"https://doi.org/10.1158/0008-5472.c.6512463.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6512463.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6512463.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083489137","display_name":"Mohammed H. Mosa","orcid":"https://orcid.org/0000-0002-8950-8470","observed_orcids":["https://orcid.org/0000-0002-8950-8470"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210153469","display_name":"Georg Speyer Haus","ror":"https://ror.org/04xmnzw38","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210153469"]},{"id":"https://openalex.org/I4210161239","display_name":"Frankfurt Cancer Institute","ror":"https://ror.org/05bx21r34","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210161239"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mohammed H. Mosa","raw_affiliation_strings":["Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany","German Cancer Consortium (DKTK), Heidelberg, Germany","German Cancer Research Center (DKFZ), Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8950-8470","affiliations":[{"raw_affiliation_string":"Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210161239"]},{"raw_affiliation_string":"Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210153469"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078807718","display_name":"Birgitta E. Michels","orcid":"https://orcid.org/0000-0001-9948-4567","observed_orcids":["https://orcid.org/0000-0001-9948-4567"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210153469","display_name":"Georg Speyer Haus","ror":"https://ror.org/04xmnzw38","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210153469"]},{"id":"https://openalex.org/I4210161239","display_name":"Frankfurt Cancer Institute","ror":"https://ror.org/05bx21r34","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210161239"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Birgitta E. Michels","raw_affiliation_strings":["Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany","German Cancer Consortium (DKTK), Heidelberg, Germany","German Cancer Research Center (DKFZ), Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9948-4567","affiliations":[{"raw_affiliation_string":"Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210161239"]},{"raw_affiliation_string":"Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210153469"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046056275","display_name":"Constantin Menche","orcid":"https://orcid.org/0009-0002-1805-3605","observed_orcids":["https://orcid.org/0009-0002-1805-3605"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210153469","display_name":"Georg Speyer Haus","ror":"https://ror.org/04xmnzw38","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210153469"]},{"id":"https://openalex.org/I4210161239","display_name":"Frankfurt Cancer Institute","ror":"https://ror.org/05bx21r34","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210161239"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Constantin Menche","raw_affiliation_strings":["Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210161239"]},{"raw_affiliation_string":"Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210153469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066428957","display_name":"Adele M. Nicolas","orcid":"https://orcid.org/0000-0003-0784-7207","observed_orcids":["https://orcid.org/0000-0003-0784-7207"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210153469","display_name":"Georg Speyer Haus","ror":"https://ror.org/04xmnzw38","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210153469"]},{"id":"https://openalex.org/I4210161239","display_name":"Frankfurt Cancer Institute","ror":"https://ror.org/05bx21r34","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210161239"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Adele M. Nicolas","raw_affiliation_strings":["Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210161239"]},{"raw_affiliation_string":"Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210153469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038750196","display_name":"Tahmineh Darvishi","orcid":"https://orcid.org/0009-0007-7024-275X","observed_orcids":["https://orcid.org/0009-0007-7024-275X"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210153469","display_name":"Georg Speyer Haus","ror":"https://ror.org/04xmnzw38","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210153469"]},{"id":"https://openalex.org/I4210161239","display_name":"Frankfurt Cancer Institute","ror":"https://ror.org/05bx21r34","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210161239"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tahmineh Darvishi","raw_affiliation_strings":["Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany","German Cancer Consortium (DKTK), Heidelberg, Germany","German Cancer Research Center (DKFZ), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210161239"]},{"raw_affiliation_string":"Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210153469"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002204711","display_name":"Florian R. Greten","orcid":"https://orcid.org/0000-0002-3928-6080","observed_orcids":["https://orcid.org/0000-0002-3928-6080"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210153469","display_name":"Georg Speyer Haus","ror":"https://ror.org/04xmnzw38","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210153469"]},{"id":"https://openalex.org/I4210161239","display_name":"Frankfurt Cancer Institute","ror":"https://ror.org/05bx21r34","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210161239"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian R. Greten","raw_affiliation_strings":["Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany","German Cancer Consortium (DKTK), Heidelberg, Germany","German Cancer Research Center (DKFZ), Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3928-6080","affiliations":[{"raw_affiliation_string":"Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210161239"]},{"raw_affiliation_string":"Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210153469"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040494071","display_name":"Henner F. Farin","orcid":"https://orcid.org/0000-0003-1558-5366","observed_orcids":["https://orcid.org/0000-0003-1558-5366"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210153469","display_name":"Georg Speyer Haus","ror":"https://ror.org/04xmnzw38","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210153469"]},{"id":"https://openalex.org/I4210161239","display_name":"Frankfurt Cancer Institute","ror":"https://ror.org/05bx21r34","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210161239"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Henner F. Farin","raw_affiliation_strings":["Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany","German Cancer Consortium (DKTK), Heidelberg, Germany","German Cancer Research Center (DKFZ), Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1558-5366","affiliations":[{"raw_affiliation_string":"Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210161239"]},{"raw_affiliation_string":"Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210153469"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5040494071"],"corresponding_institution_ids":["https://openalex.org/I114090438","https://openalex.org/I17937529","https://openalex.org/I4210153469","https://openalex.org/I4210161239","https://openalex.org/I4391767962"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.15629999339580536,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9679999947547913},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9629999995231628},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9769999980926514},{"id":"https://openalex.org/keywords/sfrp1","display_name":"SFRP1","score":0.9279999732971191},{"id":"https://openalex.org/keywords/dkk1","display_name":"DKK1","score":0.8050000071525574},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tumor-organoids","display_name":"tumor organoids","score":0.7570000290870667},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.8640000224113464},{"id":"https://openalex.org/keywords/juxtacrine-signaling","display_name":"juxtacrine signaling","score":0.7120000123977661},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8496578931808472},{"id":"https://openalex.org/C2777491412","wikidata":"https://www.wikidata.org/wiki/Q18036610","display_name":"DKK1","level":4,"score":0.7104851007461548},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6804258823394775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6366617679595947},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5674853324890137},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.562619149684906},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.557643473148346},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5212514996528625},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4464181065559387},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4369143843650818},{"id":"https://openalex.org/C2909706936","wikidata":"https://www.wikidata.org/wiki/Q42417562","display_name":"Cancer-Associated Fibroblasts","level":4,"score":0.4315629005432129},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.40818578004837036},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24917861819267273},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2490842342376709},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2264326512813568},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09498187899589539},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6512463.v1","doi":"https://doi.org/10.1158/0008-5472.c.6512463.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6512463.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6512463.v1","doi":"https://doi.org/10.1158/0008-5472.c.6512463.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6512463.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G832577324","display_name":null,"funder_award_id":"FOR 2438","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W115384338","https://openalex.org/W1934094702","https://openalex.org/W1966427351","https://openalex.org/W1985020869","https://openalex.org/W1990606472","https://openalex.org/W2011217149","https://openalex.org/W2033751993","https://openalex.org/W2038714514","https://openalex.org/W2085852125","https://openalex.org/W2085963386","https://openalex.org/W2088110734","https://openalex.org/W2103597610","https://openalex.org/W2104135721","https://openalex.org/W2106544674","https://openalex.org/W2108976255","https://openalex.org/W2135914580","https://openalex.org/W2139788242","https://openalex.org/W2140489687","https://openalex.org/W2153043700","https://openalex.org/W2154941270","https://openalex.org/W2168631000","https://openalex.org/W2171352366","https://openalex.org/W2258083311","https://openalex.org/W2299095671","https://openalex.org/W2302003756","https://openalex.org/W2314266733","https://openalex.org/W2321016022","https://openalex.org/W2579132329","https://openalex.org/W2590390825","https://openalex.org/W2600453489","https://openalex.org/W2603641223","https://openalex.org/W2619400800","https://openalex.org/W2786031287","https://openalex.org/W2788975052","https://openalex.org/W2793126529","https://openalex.org/W2798041799","https://openalex.org/W2800767913","https://openalex.org/W2805644493","https://openalex.org/W2895158524","https://openalex.org/W2898406892","https://openalex.org/W2898435366","https://openalex.org/W2901741449","https://openalex.org/W2917791553","https://openalex.org/W2943005115","https://openalex.org/W2951222857","https://openalex.org/W2973763693","https://openalex.org/W2992151131","https://openalex.org/W3028489281","https://openalex.org/W3047308150"],"related_works":["https://openalex.org/W3092702002","https://openalex.org/W2970115210","https://openalex.org/W3173299633","https://openalex.org/W3206895781","https://openalex.org/W4280580634","https://openalex.org/W4392690259","https://openalex.org/W2619400800","https://openalex.org/W4403609037","https://openalex.org/W2056869894","https://openalex.org/W2114301011"],"abstract_inverted_index":{"Abstract":[0],"Tumor":[1],"progression":[2],"is":[3],"recognized":[4],"as":[5,63,65],"a":[6,70,203],"result":[7],"of":[8,73,99,104,114,120,149,158,185,198],"an":[9,84,139],"evolving":[10],"cross-talk":[11],"between":[12],"tumor":[13,51,74,90,150,171],"cells":[14,91],"and":[15,77,135,173],"their":[16],"surrounding":[17],"nontransformed":[18],"stroma.":[19],"Although":[20],"Wnt":[21,56,95,124,187],"signaling":[22,106],"has":[23],"been":[24],"intensively":[25],"studied":[26],"in":[27,35,69,89,126,155],"colorectal":[28,199],"cancer,":[29],"it":[30],"remains":[31],"unclear":[32],"whether":[33],"activity":[34,125],"the":[36,55,118,183],"tumor-associated":[37],"stroma":[38],"contributes":[39],"to":[40],"malignancy.":[41],"To":[42],"specifically":[43],"interfere":[44],"with":[45,130,152],"stromal":[46,101],"signals,":[47],"we":[48,168],"generated":[49],"Wnt-independent":[50],"organoids":[52,151],"that":[53,81,170],"secrete":[54],"antagonist":[57],"Sfrp1.":[58],"Subcutaneous":[59],"transplantation":[60],"into":[61],"immunocompetent":[62],"well":[64],"immunodeficient":[66],"mice":[67],"resulted":[68,154],"strong":[71],"reduction":[72],"growth.":[75],"Histologic":[76],"transcriptomic":[78],"analyses":[79],"revealed":[80],"Sfrp1":[82],"induced":[83,138],"epithelial\u2013mesenchymal":[85],"transition":[86],"(EMT)":[87],"phenotype":[88],"without":[92],"affecting":[93],"tumor-intrinsic":[94],"signaling,":[96],"suggesting":[97],"involvement":[98],"nonimmune":[100],"cells.":[102],"Blockage":[103],"canonical":[105],"using":[107],"Sfrp1,":[108],"Dkk1,":[109],"or":[110,144],"fibroblast-specific":[111],"genetic":[112],"ablation":[113],"\u03b2-catenin":[115],"strongly":[116],"decreased":[117],"number":[119],"cancer-associated":[121],"myofibroblasts":[122],"(myCAF).":[123],"CAFs":[127],"was":[128],"linked":[129],"distinct":[131,179],"subtypes,":[132],"where":[133],"low":[134],"high":[136],"levels":[137],"inflammatory-like":[140],"CAF":[141],"(iCAF)":[142],"subtype":[143],"contractile":[145],"myCAFs,":[146],"respectively.":[147],"Coculture":[148],"iCAFs":[153],"significant":[156],"upregulation":[157],"EMT":[159],"markers,":[160],"while":[161],"myCAFs":[162],"reverted":[163],"this":[164],"phenotype.":[165],"In":[166],"summary,":[167],"show":[169],"growth":[172],"malignancy":[174],"are":[175],"differentially":[176],"regulated":[177],"via":[178],"fibroblast":[180],"subtypes":[181],"under":[182],"influence":[184],"juxtacrine":[186],"signals.":[188],"Significance:":[189],"This":[190],"study":[191],"provides":[192],"evidence":[193],"for":[194,207],"Wnt-induced":[195],"functional":[196],"diversity":[197],"cancer\u2013associated":[200],"fibroblasts,":[201],"representing":[202],"non-cell":[204],"autonomous":[205],"mechanism":[206],"colon":[208],"cancer":[209],"progression.":[210]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-05T00:00:00"}
