{"id":"https://openalex.org/W4361825004","doi":"https://doi.org/10.1158/0008-5472.c.6500531","title":"Data from Estrogen-Dependent and Estrogen-Independent Mechanisms Contribute to AIB1-Mediated Tumor Formation","display_name":"Data from Estrogen-Dependent and Estrogen-Independent Mechanisms Contribute to AIB1-Mediated Tumor Formation","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361825004","doi":"https://doi.org/10.1158/0008-5472.c.6500531"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6500531","doi":"https://doi.org/10.1158/0008-5472.c.6500531","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6500531","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6500531","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037769521","display_name":"Maria I. Torres\u2010Arzayus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria I. Torres-Arzayus","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute and","Division of Molecular and Cellular Oncology,","Harvard Medical School and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute and","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Division of Molecular and Cellular Oncology,","institution_ids":[]},{"raw_affiliation_string":"Harvard Medical School and","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100723224","display_name":"Jin Zhao","orcid":"https://orcid.org/0009-0000-4632-4770","observed_orcids":["https://orcid.org/0009-0000-4632-4770"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Zhao","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute and","Division of Molecular and Cellular Oncology,","Harvard Medical School and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute and","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Division of Molecular and Cellular Oncology,","institution_ids":[]},{"raw_affiliation_string":"Harvard Medical School and","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054412365","display_name":"Roderick Terry Bronson","orcid":"https://orcid.org/0000-0003-3725-2511","observed_orcids":["https://orcid.org/0000-0003-3725-2511"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roderick Bronson","raw_affiliation_strings":["Department of Pathology, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033532061","display_name":"Myles A Brown","orcid":"https://orcid.org/0000-0002-8213-1658","observed_orcids":["https://orcid.org/0000-0002-8213-1658"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Myles Brown","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute and","Division of Molecular and Cellular Oncology,","Harvard Medical School and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute and","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Division of Molecular and Cellular Oncology,","institution_ids":[]},{"raw_affiliation_string":"Harvard Medical School and","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033532061"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aib1","display_name":"AIB1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p160-coactivators","display_name":"p160 coactivators","score":0.8360000252723694},{"id":"https://openalex.org/keywords/estrogen-receptor-coactivator","display_name":"estrogen receptor coactivator","score":0.746999979019165},{"id":"https://openalex.org/keywords/estrogen-dependence","display_name":"estrogen dependence","score":0.6819999814033508},{"id":"https://openalex.org/keywords/mammary-tumors","display_name":"mammary tumors","score":0.8069999814033508},{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.9089999794960022},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pituitary-tumors","display_name":"pituitary tumors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7322647571563721},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6730953454971313},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6648967266082764},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6471055150032043},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.5089335441589355},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.4924968183040619},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4461638331413269},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4446217715740204},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.44180965423583984},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.4225732982158661},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4203437566757202},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41905859112739563},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30073052644729614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23934760689735413},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2140572965145111},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06808885931968689},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6500531","doi":"https://doi.org/10.1158/0008-5472.c.6500531","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6500531","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6500531","doi":"https://doi.org/10.1158/0008-5472.c.6500531","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6500531","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310274","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1613446635","https://openalex.org/W1782837552","https://openalex.org/W1896311502","https://openalex.org/W1963572676","https://openalex.org/W1998772680","https://openalex.org/W2002372679","https://openalex.org/W2016181677","https://openalex.org/W2047518704","https://openalex.org/W2058056109","https://openalex.org/W2060128629","https://openalex.org/W2073133361","https://openalex.org/W2079149091","https://openalex.org/W2094838095","https://openalex.org/W2097155470","https://openalex.org/W2149338552","https://openalex.org/W2153455967","https://openalex.org/W2156575042","https://openalex.org/W2158737326","https://openalex.org/W2167787018"],"related_works":["https://openalex.org/W2143283599","https://openalex.org/W2167787018","https://openalex.org/W6887996565","https://openalex.org/W2597377533","https://openalex.org/W2034139352","https://openalex.org/W1481832964","https://openalex.org/W7096110689","https://openalex.org/W3008433404","https://openalex.org/W7095938213","https://openalex.org/W2113538636"],"abstract_inverted_index":{"Abstract":[0],"We":[1,235],"have":[2],"previously":[3],"reported":[4],"the":[5,9,20,54,124,231],"oncogenic":[6,204],"properties":[7],"of":[8,19,23,39,126,153,173,188,206,211,228],"gene":[10],"amplified":[11],"in":[12,35,41,57,117,169,176,224,230],"breast":[13],"cancer":[14],"1":[15],"(AIB1),":[16],"a":[17,28,36,170,225],"member":[18],"p160":[21],"family":[22],"hormone":[24],"receptor":[25,67],"coactivators.":[26],"In":[27],"transgenic":[29,83],"mouse":[30],"model,":[31],"AIB1":[32,55,82,105,207,239],"overexpression":[33],"resulted":[34,168,223],"high":[37,226],"incidence":[38,227],"tumors":[40,144,161,229],"various":[42],"tissues,":[43],"including":[44],"mammary":[45,111,128,133,143],"gland,":[46],"uterus,":[47],"lung,":[48],"and":[49,91,114,219,233,247],"pituitary.":[50,234],"To":[51],"determine":[52],"whether":[53],"oncogenicity":[56,243],"this":[58],"model":[59],"depended":[60],"on":[61,81,150],"its":[62,212,242],"function":[63],"as":[64,215],"an":[65,184],"estrogen":[66,89,138,193],"(ER)":[68],"coactivator,":[69],"we":[70],"abolished":[71],"ER":[72,213],"signaling":[73],"through":[74,244],"two":[75],"independent":[76,210],"approaches,":[77,120,217],"by":[78,92],"performing":[79],"ovariectomy":[80,218],"(AIB1-tg)":[84],"mice":[85,95,167,182],"to":[86],"prevent":[87],"gonadal":[88],"production":[90],"crossing":[93],"AIB1-tg":[94],"with":[96],"ER\u03b1-null":[97],"mutant":[98],"mice.":[99],"Ovariectomized":[100],"(ovx)":[101],"mice,":[102,108],"but":[103],"not":[104],"\u00d7":[106],"ER\u03b1\u2212/\u2212":[107],"still":[109,222],"developed":[110],"gland":[112],"hyperplasia":[113],"ductal":[115],"carcinoma":[116],"situ.":[118],"Both":[119],"however,":[121,180],"completely":[122],"prevented":[123],"development":[125],"invasive":[127,132],"tumors,":[129],"indicating":[130],"that":[131,192,208,238],"tumor":[134,155,174],"formation":[135],"is":[136],"strictly":[137],"dependent.":[139],"Once":[140],"developed,":[141],"AIB1-induced":[142],"can":[145,240],"subsequently":[146],"lose":[147],"their":[148],"dependence":[149],"estrogen:":[151],"Injection":[152],"ER\u03b1(+)":[154],"cell":[156],"lines":[157],"derived":[158],"from":[159,197],"such":[160],"into":[162],"ovx":[163,181],"or":[164],"untreated":[165],"wild-type":[166],"similar":[171],"rate":[172,187],"growth":[175],"both":[177,216],"groups.":[178],"Surprisingly,":[179],"had":[183],"\u223c4-fold":[185],"higher":[186],"metastasis":[189,198],"formation,":[190],"suggesting":[191],"provided":[194],"some":[195],"protection":[196],"formation.":[199],"Lastly,":[200],"our":[201],"experiments":[202],"identified":[203],"functions":[205],"are":[209],"coactivation,":[214],"ER\u2212/\u2212":[220],"crosses,":[221],"lung":[232],"therefore":[236],"conclude":[237],"exert":[241],"tissue-specific":[245],"estrogen-dependent":[246],"estrogen-independent":[248],"functions.":[249],"Cancer":[250],"Res;":[251],"70(10);":[252],"4102\u201311.":[253],"\u00a92010":[254],"AACR.":[255]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}