{"id":"https://openalex.org/W4361824835","doi":"https://doi.org/10.1158/0008-5472.c.6512085.v1","title":"Data from Cancer-Induced Muscle Wasting Requires p38\u03b2 MAPK Activation of p300","display_name":"Data from Cancer-Induced Muscle Wasting Requires p38\u03b2 MAPK Activation of p300","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361824835","doi":"https://doi.org/10.1158/0008-5472.c.6512085.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6512085.v1","doi":"https://doi.org/10.1158/0008-5472.c.6512085.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6512085.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6512085.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041443463","display_name":"Thomas K. Sin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas K. Sin","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100339805","display_name":"Guohua Zhang","orcid":"https://orcid.org/0000-0003-3275-6905","observed_orcids":["https://orcid.org/0000-0003-3275-6905"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guohua Zhang","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101797194","display_name":"Zicheng Zhang","orcid":"https://orcid.org/0000-0002-9631-4316","observed_orcids":["https://orcid.org/0000-0002-9631-4316"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zicheng Zhang","raw_affiliation_strings":["University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050537513","display_name":"James Z. Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Z. Zhu","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101436506","display_name":"Yan Zuo","orcid":"https://orcid.org/0009-0009-8341-5570","observed_orcids":["https://orcid.org/0009-0009-8341-5570"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Zuo","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046674705","display_name":"Jeffrey A. Frost","orcid":"https://orcid.org/0000-0001-9722-1536","observed_orcids":["https://orcid.org/0000-0001-9722-1536"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Frost","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400752","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-7113-2700","observed_orcids":["https://orcid.org/0000-0002-7113-2700","https://orcid.org/0000-0002-5551-0134","https://orcid.org/0009-0008-7671-1462"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas","Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","The Vivian L. Smith Depart-ment of Neurosurgery, The University of Texas Health Science Center at Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"The Vivian L. Smith Depart-ment of Neurosurgery, The University of Texas Health Science Center at Houston, Houston, Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100628291","display_name":"Yiping Li","orcid":"https://orcid.org/0000-0003-2188-6958","observed_orcids":["https://orcid.org/0000-0003-2188-6958"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Ping Li","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.09120000153779984,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-cachexia","display_name":"cancer cachexia","score":0.8500000238418579},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nilotinib","display_name":"nilotinib","score":0.9120000004768372},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.6110000014305115},{"id":"https://openalex.org/keywords/skeletal-muscle-catabolism","display_name":"skeletal muscle catabolism","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-bearing-mice","display_name":"tumor-bearing mice","score":0.7200000286102295},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.755752682685852},{"id":"https://openalex.org/C2777413986","wikidata":"https://www.wikidata.org/wiki/Q412327","display_name":"Nilotinib","level":4,"score":0.6756199598312378},{"id":"https://openalex.org/C2777704314","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cachexia","level":3,"score":0.6752020716667175},{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.6465164422988892},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.583476185798645},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5420651435852051},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5403035879135132},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5334202647209167},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5176830291748047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43890824913978577},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4196835160255432},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40340620279312134},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.35640817880630493},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3537924289703369},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27340176701545715},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17606788873672485},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0673641562461853},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6512085.v1","doi":"https://doi.org/10.1158/0008-5472.c.6512085.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6512085.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6512085.v1","doi":"https://doi.org/10.1158/0008-5472.c.6512085.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6512085.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4056138739","display_name":"Prognostic Biomarkers for ZIP4-mediated Cachexia in Pancreatic Cancer","funder_award_id":"R01CA203108","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320321514","display_name":"Central South University","ror":"https://ror.org/00f1zfq44"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1965909642","https://openalex.org/W1977177366","https://openalex.org/W1992995822","https://openalex.org/W1993792235","https://openalex.org/W1997155298","https://openalex.org/W2019558909","https://openalex.org/W2034127653","https://openalex.org/W2043127198","https://openalex.org/W2061838604","https://openalex.org/W2090101716","https://openalex.org/W2093322643","https://openalex.org/W2107441200","https://openalex.org/W2117066780","https://openalex.org/W2145280166","https://openalex.org/W2158933399","https://openalex.org/W2170356930","https://openalex.org/W2177984400","https://openalex.org/W2288173083","https://openalex.org/W2414773926","https://openalex.org/W2615927929","https://openalex.org/W2733043835","https://openalex.org/W2737050825","https://openalex.org/W2754168513","https://openalex.org/W2784374589","https://openalex.org/W2791955556","https://openalex.org/W2896710157","https://openalex.org/W2912925714","https://openalex.org/W2958857500","https://openalex.org/W2970650601"],"related_works":["https://openalex.org/W3116082743","https://openalex.org/W4361824834","https://openalex.org/W2912925714","https://openalex.org/W2144720369","https://openalex.org/W2896795033","https://openalex.org/W4225716520","https://openalex.org/W4415405576","https://openalex.org/W6979751934","https://openalex.org/W6983697259","https://openalex.org/W2350198083"],"abstract_inverted_index":{"Abstract":[0],"Cancer-associated":[1],"cachexia,":[2,198],"characterized":[3],"by":[4,27,190],"muscle":[5,25,80,94,124,152],"wasting,":[6,153],"is":[7,47,74,85],"a":[8,86,140,163,200],"lethal":[9],"metabolic":[10],"syndrome":[11],"without":[12,130],"defined":[13],"etiology":[14],"or":[15],"established":[16],"treatment.":[17],"We":[18],"previously":[19],"found":[20],"that":[21,40,52,103,182],"p300":[22,42,68,109,189],"mediates":[23],"cancer-induced":[24,54,93],"wasting":[26],"activating":[28],"C/EBP\u03b2,":[29],"which":[30,73],"then":[31],"upregulates":[32],"key":[33],"catabolic":[34],"genes.":[35],"However,":[36],"the":[37,115,191],"signaling":[38],"mechanism":[39],"activates":[41],"in":[43,60,127,146],"response":[44],"to":[45,69,78,161,171],"cancer":[46,122,168,197],"unknown.":[48],"Here,":[49],"we":[50],"show":[51],"upon":[53],"activation":[55,110,187],"of":[56,92,137,175,184,188],"Toll-like":[57],"receptor":[58],"4":[59],"skeletal":[61],"muscle,":[62],"p38\u03b2":[63,83,106,176,185],"MAPK":[64,84,117],"phosphorylates":[65],"Ser-12":[66],"on":[67],"stimulate":[70],"C/EBP\u03b2":[71],"acetylation,":[72],"necessary":[75],"and":[76,89,120],"sufficient":[77],"cause":[79],"wasting.":[81,95],"Thus,":[82],"central":[87],"mediator":[88],"therapeutic":[90,202],"target":[91],"In":[96],"addition,":[97],"nilotinib,":[98,195],"an":[99],"FDA-approved":[100,192],"kinase":[101,193],"inhibitor":[102],"preferentially":[104],"binds":[105],"MAPK,":[107],"inhibited":[108],"20-fold":[111],"more":[112],"potently":[113],"than":[114],"p38\u03b1/\u03b2":[116],"inhibitor,":[118,194],"SB202190,":[119],"abrogated":[121],"cell\u2013induced":[123],"protein":[125],"loss":[126],"C2C12":[128],"myotubes":[129],"suppressing":[131],"p38\u03b1":[132],"MAPK\u2013dependent":[133],"myogenesis.":[134],"Systemic":[135],"administration":[136],"nilotinib":[138,159],"at":[139],"low":[141],"dose":[142],"(0.5":[143],"mg/kg/day,":[144],"i.p.)":[145],"tumor-bearing":[147],"mice":[148],"not":[149],"only":[150],"alleviated":[151],"but":[154],"also":[155],"prolonged":[156],"survival.":[157],"Therefore,":[158],"appears":[160],"be":[162],"promising":[164],"treatment":[165],"for":[166],"human":[167],"cachexia":[169],"due":[170],"its":[172],"selective":[173],"inhibition":[174],"MAPK.":[177],"Significance:":[178],"These":[179],"findings":[180],"demonstrate":[181],"prevention":[183],"MAPK\u2013mediated":[186],"ameliorates":[196],"representing":[199],"potential":[201],"strategy":[203],"against":[204],"this":[205],"syndrome.":[206]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-05T00:00:00"}
