{"id":"https://openalex.org/W4361823905","doi":"https://doi.org/10.1158/0008-5472.c.6513193.v1","title":"Data from MTAP Deficiency\u2013Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting De Novo Purine Synthesis and Glycolysis in Pancreatic Cancer","display_name":"Data from MTAP Deficiency\u2013Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting De Novo Purine Synthesis and Glycolysis in Pancreatic Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361823905","doi":"https://doi.org/10.1158/0008-5472.c.6513193.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6513193.v1","doi":"https://doi.org/10.1158/0008-5472.c.6513193.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6513193.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6513193.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021423929","display_name":"Qiangsheng Hu","orcid":"https://orcid.org/0000-0001-7469-1359","observed_orcids":["https://orcid.org/0000-0001-7469-1359"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiangsheng Hu","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","Pancreatic Cancer Institute, Fudan University, Shanghai, China","Shanghai Pancreatic Cancer Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Pancreatic Cancer Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Pancreatic Cancer Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100711578","display_name":"Yi Qin","orcid":"https://orcid.org/0000-0002-6019-3719","observed_orcids":["https://orcid.org/0000-0002-6019-3719"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Qin","raw_affiliation_strings":["Cancer Research Institute, Fudan University Shanghai Cancer Center, Shanghai, China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","Pancreatic Cancer Institute, Fudan University, Shanghai, China","Shanghai Pancreatic Cancer Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Pancreatic Cancer Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Pancreatic Cancer Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000579442","display_name":"Shunrong Ji","orcid":"https://orcid.org/0000-0001-5497-241X","observed_orcids":["https://orcid.org/0000-0001-5497-241X","https://orcid.org/0000-0003-2556-3320"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shunrong Ji","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","Pancreatic Cancer Institute, Fudan University, Shanghai, China","Shanghai Pancreatic Cancer Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Pancreatic Cancer Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Pancreatic Cancer Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051700425","display_name":"Xiuhui Shi","orcid":"https://orcid.org/0000-0002-5327-8247","observed_orcids":["https://orcid.org/0000-0002-5327-8247"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiuhui Shi","raw_affiliation_strings":["Department of Medicine, Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048739174","display_name":"Weixing Dai","orcid":"https://orcid.org/0000-0002-5395-8568","observed_orcids":["https://orcid.org/0000-0002-5395-8568"]},"institutions":[{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weixing Dai","raw_affiliation_strings":["Cancer Research Institute, Fudan University Shanghai Cancer Center, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064651955","display_name":"Guixiong Fan","orcid":"https://orcid.org/0009-0004-3995-612X","observed_orcids":["https://orcid.org/0009-0004-3995-612X"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guixiong Fan","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","Pancreatic Cancer Institute, Fudan University, Shanghai, China","Shanghai Pancreatic Cancer Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Pancreatic Cancer Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Pancreatic Cancer Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shuo Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuo Li","raw_affiliation_strings":["Shanghai Pancreatic Cancer Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Pancreatic Cancer Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113364539","display_name":"Wenyan Xu","orcid":"https://orcid.org/0009-0006-3701-562X","observed_orcids":["https://orcid.org/0009-0006-3701-562X","https://orcid.org/0000-0003-2671-0345"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyan Xu","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","Pancreatic Cancer Institute, Fudan University, Shanghai, China","Shanghai Pancreatic Cancer Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Pancreatic Cancer Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Pancreatic Cancer Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100678274","display_name":"Wensheng Liu","orcid":"https://orcid.org/0000-0003-4357-1893","observed_orcids":["https://orcid.org/0000-0003-4357-1893"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wensheng Liu","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","Pancreatic Cancer Institute, Fudan University, Shanghai, China","Shanghai Pancreatic Cancer Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Pancreatic Cancer Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Pancreatic Cancer Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100757658","display_name":"Mengqi Liu","orcid":"https://orcid.org/0000-0002-9881-404X","observed_orcids":["https://orcid.org/0000-0002-9881-404X","https://orcid.org/0000-0003-2129-7950"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Mengqi Liu","raw_affiliation_strings":["Department of Medicine,","Department of Surgery, The University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1262A, Oklahoma City, OK 73104","Fudan University Shanghai Cancer Center,","Fudan University, Shanghai Pancreatic Cancer Institute, 270 DongAn Road, Shanghai 200032, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Department of Surgery, The University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1262A, Oklahoma City, OK 73104","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Fudan University Shanghai Cancer Center,","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Fudan University, Shanghai Pancreatic Cancer Institute, 270 DongAn Road, Shanghai 200032, P.R. China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100459113","display_name":"Zheng Zhang","orcid":"https://orcid.org/0000-0002-3242-5738","observed_orcids":["https://orcid.org/0000-0002-3242-5738"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Zhang","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","Pancreatic Cancer Institute, Fudan University, Shanghai, China","Shanghai Pancreatic Cancer Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Pancreatic Cancer Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Pancreatic Cancer Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101727201","display_name":"Ye Zeng","orcid":"https://orcid.org/0000-0003-1207-6486","observed_orcids":["https://orcid.org/0000-0003-1207-6486"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeng Ye","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","Pancreatic Cancer Institute, Fudan University, Shanghai, China","Shanghai Pancreatic Cancer Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Pancreatic Cancer Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Pancreatic Cancer Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051324146","display_name":"Zhijun Zhou","orcid":"https://orcid.org/0000-0003-2226-2223","observed_orcids":["https://orcid.org/0000-0003-2226-2223"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zhijun Zhou","raw_affiliation_strings":["Department of Medicine, Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","Pancreatic Cancer Institute, Fudan University, Shanghai, China","Shanghai Pancreatic Cancer Institute, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0003-2226-2223","affiliations":[{"raw_affiliation_string":"Department of Medicine, Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Pancreatic Cancer Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Pancreatic Cancer Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011227285","display_name":"Jingxuan Yang","orcid":"https://orcid.org/0000-0003-3265-161X","observed_orcids":["https://orcid.org/0000-0003-3265-161X"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingxuan Yang","raw_affiliation_strings":["Department of Medicine, Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":"https://orcid.org/0000-0003-3265-161X","affiliations":[{"raw_affiliation_string":"Department of Medicine, Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054031774","display_name":"Qifeng Zhuo","orcid":"https://orcid.org/0000-0003-0248-331X","observed_orcids":["https://orcid.org/0000-0003-0248-331X"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qifeng Zhuo","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","Pancreatic Cancer Institute, Fudan University, Shanghai, China","Shanghai Pancreatic Cancer Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Pancreatic Cancer Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Pancreatic Cancer Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100374639","display_name":"Xianjun Yu","orcid":"https://orcid.org/0000-0002-6697-7143","observed_orcids":["https://orcid.org/0000-0002-6697-7143"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianjun Yu","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","Pancreatic Cancer Institute, Fudan University, Shanghai, China","Shanghai Pancreatic Cancer Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Pancreatic Cancer Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Pancreatic Cancer Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400736","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-3971-9130","observed_orcids":["https://orcid.org/0000-0002-3971-9130"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["Department of Medicine, Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100605525","display_name":"Xiaowu Xu","orcid":"https://orcid.org/0000-0001-5792-9839","observed_orcids":["https://orcid.org/0000-0001-5792-9839"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowu Xu","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","Pancreatic Cancer Institute, Fudan University, Shanghai, China","Shanghai Pancreatic Cancer Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Pancreatic Cancer Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Pancreatic Cancer Institute, Shanghai, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.5238999724388123,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.5238999724388123,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.40139999985694885,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtap-deficiency","display_name":"MTAP deficiency","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9769999980926514},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.9459999799728394},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/de-novo-purine-synthesis","display_name":"de novo purine synthesis","score":0.996999979019165},{"id":"https://openalex.org/keywords/hif-1alpha-stabilization","display_name":"HIF-1\u03b1 stabilization","score":0.9039999842643738},{"id":"https://openalex.org/keywords/riok1","display_name":"RIOK1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/2-deoxy-d-glucose","display_name":"2-deoxyglucose","score":0.8379999995231628},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.628000020980835},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7160000205039978},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7058416604995728},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.5883258581161499},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.583159327507019},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4475805461406708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41907694935798645},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4111822247505188},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3759758174419403},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3095495402812958},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29096749424934387},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2263852059841156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21711599826812744}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6513193.v1","doi":"https://doi.org/10.1158/0008-5472.c.6513193.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6513193.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6513193.v1","doi":"https://doi.org/10.1158/0008-5472.c.6513193.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6513193.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3377574098","display_name":null,"funder_award_id":"81625016","funder_id":"https://openalex.org/F4320336125","funder_display_name":"National Science Fund for Distinguished Young Scholars"},{"id":"https://openalex.org/G4758882156","display_name":null,"funder_award_id":"81625016","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4827053189","display_name":null,"funder_award_id":"2019-01-07-00-07-E00057","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6347225829","display_name":null,"funder_award_id":"81625016","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8050155218","display_name":null,"funder_award_id":"81871950","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G865850907","display_name":null,"funder_award_id":"2019-01","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G988355653","display_name":null,"funder_award_id":"81972250","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320336125","display_name":"National Science Fund for Distinguished Young Scholars","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W45284719","https://openalex.org/W1526987695","https://openalex.org/W1864264858","https://openalex.org/W1984264526","https://openalex.org/W1998628096","https://openalex.org/W2003653590","https://openalex.org/W2019299732","https://openalex.org/W2031211461","https://openalex.org/W2033160470","https://openalex.org/W2051257252","https://openalex.org/W2066050590","https://openalex.org/W2066379425","https://openalex.org/W2070454905","https://openalex.org/W2077945404","https://openalex.org/W2099023480","https://openalex.org/W2102416115","https://openalex.org/W2103562758","https://openalex.org/W2106825335","https://openalex.org/W2110020665","https://openalex.org/W2111945921","https://openalex.org/W2114843025","https://openalex.org/W2122339465","https://openalex.org/W2138386102","https://openalex.org/W2149441684","https://openalex.org/W2163018106","https://openalex.org/W2287840388","https://openalex.org/W2297486194","https://openalex.org/W2321587450","https://openalex.org/W2470517880","https://openalex.org/W2491220498","https://openalex.org/W2522437666","https://openalex.org/W2582166823","https://openalex.org/W2605682092","https://openalex.org/W2741282735","https://openalex.org/W2741605333","https://openalex.org/W2758067903","https://openalex.org/W2771670527","https://openalex.org/W2775853582","https://openalex.org/W2803664483","https://openalex.org/W2912467927","https://openalex.org/W2922572041","https://openalex.org/W2940707333","https://openalex.org/W2942790831","https://openalex.org/W2967091916","https://openalex.org/W2976596173","https://openalex.org/W3008313240","https://openalex.org/W3010195317","https://openalex.org/W3120617198","https://openalex.org/W3142605790","https://openalex.org/W4229801234","https://openalex.org/W4255872931"],"related_works":["https://openalex.org/W3189157262","https://openalex.org/W4361878473","https://openalex.org/W4362424154","https://openalex.org/W4361971620","https://openalex.org/W4361878302","https://openalex.org/W4361878702","https://openalex.org/W4361879563","https://openalex.org/W4362424131","https://openalex.org/W2080951657","https://openalex.org/W7214798132"],"abstract_inverted_index":{"Abstract":[0],"Methylthioadenosine":[1],"phosphorylase":[2],"(MTAP)":[3],"is":[4,17],"a":[5,34,63,108,165],"key":[6],"enzyme":[7],"associated":[8],"with":[9,39,59,116],"the":[10,129,135],"salvage":[11],"of":[12,23,49,65],"methionine":[13],"and":[14,79,117,134,168,184],"adenine":[15],"that":[16,30,57,71,72,92,128,153,179],"deficient":[18],"in":[19,84,112],"20%":[20],"to":[21,120,143],"30%":[22],"pancreatic":[24,40,85,146,157,195],"cancer.":[25,196],"Our":[26],"previous":[27],"study":[28,177],"revealed":[29,91],"MTAP":[31,60,73,93,154,180],"deficiency":[32,61,155],"indicates":[33],"poor":[35],"prognosis":[36],"for":[37,171],"patients":[38],"ductal":[41],"adenocarcinoma":[42],"(PDAC).":[43],"In":[44,124],"this":[45],"study,":[46],"bioinformatics":[47],"analysis":[48,90],"The":[50],"Cancer":[51],"Genome":[52],"Atlas":[53],"(TCGA)":[54],"data":[55],"indicated":[56],"PDACs":[58],"display":[62],"signature":[64],"elevated":[66],"glycolysis.":[67],"Metabolomics":[68],"studies":[69],"showed":[70],"deletion\u2013mediated":[74],"metabolic":[75,162],"reprogramming":[76],"enhanced":[77],"glycolysis":[78,130],"de":[80,136],"novo":[81,137],"purine":[82,138,185],"synthesis":[83,139],"cancer":[86,147,158],"cells.":[87,148],"Western":[88],"blot":[89],"knockout":[94],"stabilized":[95],"hypoxia-inducible":[96],"factor":[97],"1\u03b1":[98],"(HIF1\u03b1)":[99],"protein":[100],"via":[101],"posttranslational":[102],"phosphorylation.":[103],"RIO":[104],"kinase":[105,110],"1":[106],"(RIOK1),":[107],"downstream":[109],"upregulated":[111],"MTAP-deficient":[113,145,173,194],"cells,":[114],"interacted":[115],"phosphorylated":[118],"HIF1\u03b1":[119],"regulate":[121],"its":[122],"stability.":[123],"vitro":[125],"experiments":[126],"demonstrated":[127],"inhibitor":[131,140],"2-deoxy-d-glucose":[132],"(2-DG)":[133],"l-alanosine":[141],"synergized":[142],"kill":[144],"Collectively,":[149],"these":[150],"results":[151],"reveal":[152],"drives":[156],"progression":[159],"by":[160],"inducing":[161],"reprogramming,":[163],"providing":[164],"novel":[166,190],"target":[167],"therapeutic":[169],"strategy":[170],"treating":[172],"disease.":[174],"Significance:":[175],"This":[176],"demonstrates":[178],"status":[181],"impacts":[182],"glucose":[183],"metabolism,":[186],"thus":[187],"identifying":[188],"multiple":[189],"treatment":[191],"options":[192],"against":[193]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-04-05T00:00:00"}
