{"id":"https://openalex.org/W4361823766","doi":"https://doi.org/10.1158/0008-5472.c.6500763","title":"Data from Oncogenic Wip1 Phosphatase Is Inhibited by miR-16 in the DNA Damage Signaling Pathway","display_name":"Data from Oncogenic Wip1 Phosphatase Is Inhibited by miR-16 in the DNA Damage Signaling Pathway","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361823766","doi":"https://doi.org/10.1158/0008-5472.c.6500763"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6500763","doi":"https://doi.org/10.1158/0008-5472.c.6500763","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6500763","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6500763","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072661022","display_name":"Xinna Zhang","orcid":"https://orcid.org/0000-0003-4118-2245","observed_orcids":["https://orcid.org/0000-0003-4118-2245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinna Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051423462","display_name":"Guohui Wan","orcid":"https://orcid.org/0000-0001-5170-7282","observed_orcids":["https://orcid.org/0000-0001-5170-7282"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guohui Wan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054846213","display_name":"Sizolwenkosi Mlotshwa","orcid":"https://orcid.org/0000-0002-2973-2489","observed_orcids":["https://orcid.org/0000-0002-2973-2489"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sizolwenkosi Mlotshwa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079353531","display_name":"Vicki Bowman Vance","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vicki Vance","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110894550","display_name":"Franklin G. Berger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Franklin G. Berger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114375978","display_name":"Hexin Chen","orcid":"https://orcid.org/0000-0001-9300-0859","observed_orcids":["https://orcid.org/0000-0001-9300-0859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hexin Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081753593","display_name":"Xiongbin Lu","orcid":"https://orcid.org/0000-0002-7987-9825","observed_orcids":["https://orcid.org/0000-0002-7987-9825"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiongbin Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wip1-phosphatase","display_name":"Wip1 phosphatase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mir-16","display_name":"miR-16","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9179999828338623},{"id":"https://openalex.org/keywords/atm-atr-signaling","display_name":"ATM/ATR signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9670000076293945},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7860000133514404},{"id":"https://openalex.org/keywords/doxorubicin-sensitivity","display_name":"doxorubicin sensitivity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7979999780654907},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.806692361831665},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7195714712142944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.549688994884491},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5358344912528992},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5157485604286194},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5129758715629578},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5106421113014221},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4978044033050537},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4943513870239258},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.445410817861557},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43164199590682983},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.42192280292510986},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39630430936813354},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39488646388053894},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.37436753511428833},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.23120561242103577},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17368382215499878},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14981478452682495},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6500763","doi":"https://doi.org/10.1158/0008-5472.c.6500763","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6500763","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6500763","doi":"https://doi.org/10.1158/0008-5472.c.6500763","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6500763","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2151312288","https://openalex.org/W2079204151","https://openalex.org/W2087772087","https://openalex.org/W3152573795","https://openalex.org/W2594609811","https://openalex.org/W2480344451","https://openalex.org/W7074242480","https://openalex.org/W2074364031","https://openalex.org/W3029731384","https://openalex.org/W1955123431"],"abstract_inverted_index":{"Abstract":[0],"Wild-type":[1],"p53-induced":[2],"phosphatase":[3,217],"1":[4],"(Wip1)":[5],"was":[6,53],"identified":[7,77],"as":[8],"an":[9,207],"oncogene":[10],"amplified":[11],"and":[12,41,71,88,129,161,183,191,223],"overexpressed":[13],"in":[14,27,108,146,156,168,212,218],"several":[15,36],"human":[16,194],"cancers.":[17],"Recent":[18],"evidence":[19],"suggested":[20],"that":[21,51,81,117],"Wip1":[22,34,52,87,109,179,216],"is":[23,99,112],"a":[24,78,123,131],"critical":[25],"inhibitor":[26],"the":[28,59,63,69,84,92,106,135,147,181,199,213,219],"ATM/ATR-p53":[29],"DNA":[30,38,43,64,103,137,220],"damage":[31,65,138,221],"signaling":[32,128],"pathway.":[33],"dephosphorylates":[35],"key":[37],"damage\u2013responsive":[39],"proteins":[40],"reverses":[42],"damage\u2013induced":[44],"cell":[45],"cycle":[46],"checkpoints.":[47],"Previous":[48],"reports":[49],"showed":[50],"transcriptionally":[54],"induced":[55,100],"by":[56],"p53":[57],"at":[58],"early":[60,136],"stage":[61],"of":[62,74,86,95,118,126,134,149,174,178,185,210,215],"response.":[66,139],"To":[67,140],"investigate":[68],"temporal":[70],"functional":[72,132],"regulation":[73,214],"Wip1,":[75],"we":[76,152],"microRNA,":[79],"miR-16,":[80],"specifically":[82],"targets":[83],"mRNA":[85,120],"thus":[89],"negatively":[90],"regulates":[91],"expression":[93,155],"level":[94,111],"Wip1.":[96],"miR-16":[97,143,175,211],"itself":[98],"immediately":[101],"after":[102],"damage.":[104],"Therefore,":[105],"increase":[107],"protein":[110],"significantly":[113],"postponed":[114],"compared":[115],"with":[116],"its":[119,154],"level,":[121],"preventing":[122],"premature":[124],"inactivation":[125],"ATM/ATR":[127],"allowing":[130],"completion":[133],"better":[141],"understand":[142],"biological":[144],"functions":[145],"context":[148],"cancer":[150,196],"cells,":[151],"examined":[153],"mammary":[157,169,187,224],"tumor":[158,170,188],"stem":[159,171,189],"cells":[160,190,197],"found":[162],"it":[163],"to":[164,198],"be":[165],"markedly":[166],"downregulated":[167],"cells.":[172],"Overexpression":[173],"or":[176],"inhibition":[177],"suppresses":[180],"self-renewal":[182],"growth":[184],"mouse":[186],"sensitizes":[192],"MCF-7":[193],"breast":[195],"chemotherapeutic":[200],"drug":[201],"doxorubicin.":[202],"Together,":[203],"our":[204],"results":[205],"suggest":[206],"important":[208],"role":[209],"response":[222],"tumorigenesis.":[225],"Cancer":[226],"Res;":[227],"70(18);":[228],"7176\u201386.":[229],"\u00a92010":[230],"AACR.":[231]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-04-05T00:00:00"}
