{"id":"https://openalex.org/W4361823358","doi":"https://doi.org/10.1158/0008-5472.c.6512302","title":"Data from Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2","display_name":"Data from Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361823358","doi":"https://doi.org/10.1158/0008-5472.c.6512302"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6512302","doi":"https://doi.org/10.1158/0008-5472.c.6512302","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6512302","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6512302","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112904407","display_name":"Ninghui Mao","orcid":"https://orcid.org/0000-0003-1605-9608","observed_orcids":["https://orcid.org/0000-0003-1605-9608"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ninghui Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100532052","display_name":"Dong Gao","orcid":"https://orcid.org/0000-0003-1821-2741","observed_orcids":["https://orcid.org/0000-0003-1821-2741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035094762","display_name":"Wenhuo Hu","orcid":"https://orcid.org/0000-0002-8686-7160","observed_orcids":["https://orcid.org/0000-0002-8686-7160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenhuo Hu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8686-7160","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017549154","display_name":"Sunyana Gadal","orcid":"https://orcid.org/0000-0003-3073-4067","observed_orcids":["https://orcid.org/0000-0003-3073-4067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunyana Gadal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084281221","display_name":"Haley Hieronymus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haley Hieronymus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101705000","display_name":"Shangqian Wang","orcid":"https://orcid.org/0000-0002-5776-1973","observed_orcids":["https://orcid.org/0000-0002-5776-1973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shangqian Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100736742","display_name":"Young Sun Lee","orcid":"https://orcid.org/0000-0002-6612-7341","observed_orcids":["https://orcid.org/0000-0002-6612-7341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young Sun Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6612-7341","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037676979","display_name":"Patrick Sullivan","orcid":"https://orcid.org/0000-0002-3784-4114","observed_orcids":["https://orcid.org/0000-0002-3784-4114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Sullivan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3784-4114","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024562035","display_name":"Zeda Zhang","orcid":"https://orcid.org/0000-0002-7225-534X","observed_orcids":["https://orcid.org/0000-0002-7225-534X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeda Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088529666","display_name":"Danielle Choi","orcid":"https://orcid.org/0000-0002-1816-1924","observed_orcids":["https://orcid.org/0000-0002-1816-1924"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danielle Choi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060228803","display_name":"Neal X. Rosen","orcid":"https://orcid.org/0000-0002-8307-654X","observed_orcids":["https://orcid.org/0000-0002-8307-654X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neal Rosen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8307-654X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034963668","display_name":"Charles L. Sawyers","orcid":"https://orcid.org/0000-0003-4955-6475","observed_orcids":["https://orcid.org/0000-0003-4955-6475"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles L. Sawyers","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4955-6475","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010079764","display_name":"Anuradha Gopalan","orcid":"https://orcid.org/0009-0007-6017-0991","observed_orcids":["https://orcid.org/0009-0007-6017-0991"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anuradha Gopalan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402085","display_name":"Yu Chen","orcid":"https://orcid.org/0000-0001-8484-040X","observed_orcids":["https://orcid.org/0000-0001-8484-040X","https://orcid.org/0000-0003-4471-3953"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042883465","display_name":"Brett Stewart Carver","orcid":"https://orcid.org/0000-0001-5165-3544","observed_orcids":["https://orcid.org/0000-0001-5165-3544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brett S. Carver","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erg-oncogene","display_name":"ERG oncogene","score":0.718999981880188},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.7990000247955322},{"id":"https://openalex.org/keywords/irs2","display_name":"insulin receptor substrate 2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pten-loss","display_name":"PTEN loss","score":0.9480000138282776},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/genomic-rearrangements","display_name":"genome rearrangement","score":0.8379999995231628},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7649999856948853},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-signaling","display_name":"receptor tyrosine kinase signaling","score":0.609000027179718},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.878000020980835},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.913057804107666},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7503936290740967},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6961782574653625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6642345190048218},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6526442766189575},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6111120581626892},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5501816272735596},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.43067342042922974},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3843478560447693},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29622602462768555},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25389787554740906}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6512302","doi":"https://doi.org/10.1158/0008-5472.c.6512302","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6512302","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6512302","doi":"https://doi.org/10.1158/0008-5472.c.6512302","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6512302","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3004414444","https://openalex.org/W2954274900","https://openalex.org/W3184425470","https://openalex.org/W2087207490","https://openalex.org/W2745757975","https://openalex.org/W2049205984","https://openalex.org/W4393076526","https://openalex.org/W2006722332","https://openalex.org/W7164818161","https://openalex.org/W3087575066"],"abstract_inverted_index":{"Abstract":[0],"Genomic":[1],"rearrangements":[2],"leading":[3,70],"to":[4,41,71,181,207],"the":[5,11,24,116,133,142,152,175,201],"aberrant":[6],"expression":[7],"of":[8,27,47,68,95,99,121,135,137,141,177,203],"ERG":[9,35,60,160],"are":[10,20],"most":[12,153],"common":[13],"early":[14],"events":[15,171,197],"in":[16,50,107,132],"prostate":[17,84],"cancer":[18],"and":[19,75,92],"significantly":[21],"enriched":[22],"for":[23],"concomitant":[25,179,205],"loss":[26,46,120,136],"PTEN.":[28,138],"Genetically":[29],"engineered":[30],"mouse":[31],"models":[32],"reveal":[33],"that":[34,58,157],"overexpression":[36,98],"alone":[37],"is":[38,126],"not":[39,113,127],"sufficient":[40],"induce":[42],"tumorigenesis,":[43],"but":[44],"combined":[45],"PTEN":[48,122,143],"results":[49],"an":[51],"aggressive":[52],"invasive":[53],"phenotype.":[54],"Here,":[55],"we":[56],"show":[57],"oncogenic":[59,170,183,196],"repressed":[61,88],"PI3K":[62,102,124,148],"signaling":[63,125,184],"through":[64],"direct":[65],"transcriptional":[66,93],"suppression":[67],"IRS2,":[69],"reduced":[72],"RTK":[73],"levels":[74],"activity.":[76],"In":[77],"accordance":[78],"with":[79,119,159],"this":[80,111],"finding,":[81],"ERG-positive":[82],"human":[83],"cancers":[85],"had":[86],"a":[87,108],"AKT":[89],"gene":[90],"signature":[91],"downregulation":[94],"IRS2.":[96],"Although":[97],"IRS2":[100],"activated":[101],"signaling,":[103,149],"promoting":[104],"cell":[105],"migration":[106],"PI3K-dependent":[109],"manner,":[110],"did":[112],"fully":[114],"recapitulate":[115],"phenotype":[117],"seen":[118],"as":[123,128,130],"robust":[129],"observed":[131],"setting":[134],"Importantly,":[139],"deletions":[140],"locus,":[144],"which":[145],"promotes":[146],"active":[147],"were":[150],"among":[151],"significant":[154],"copy-number":[155],"alterations":[156,180,206],"co-occurred":[158],"genomic":[161],"rearrangements.":[162],"This":[163,189],"work":[164,190],"provides":[165,191],"insight":[166,192],"on":[167,193],"how":[168,194],"initiating":[169,195],"may":[172,198],"directly":[173,199],"influence":[174,200],"selection":[176,202],"secondary":[178,204],"promote":[182,208],"during":[185],"tumor":[186],"evolution.":[187],"Significance:":[188],"tumorigenesis.":[209]},"counts_by_year":[],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2023-04-05T00:00:00"}
