{"id":"https://openalex.org/W4361823285","doi":"https://doi.org/10.1158/0008-5472.c.6512010","title":"Data from Heritability of Mammographic Breast Density, Density Change, Microcalcifications, and Masses","display_name":"Data from Heritability of Mammographic Breast Density, Density Change, Microcalcifications, and Masses","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361823285","doi":"https://doi.org/10.1158/0008-5472.c.6512010"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6512010","doi":"https://doi.org/10.1158/0008-5472.c.6512010","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6512010","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6512010","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032048264","display_name":"Natalie Holowko","orcid":"https://orcid.org/0000-0002-9124-3264","observed_orcids":["https://orcid.org/0000-0002-9124-3264"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalie Holowko","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9124-3264","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037999437","display_name":"Mikael Eriksson","orcid":"https://orcid.org/0000-0001-8135-4270","observed_orcids":["https://orcid.org/0000-0001-8135-4270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikael Eriksson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8135-4270","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052670662","display_name":"Ralf Kuja\u2010Halkola","orcid":"https://orcid.org/0000-0002-3765-2067","observed_orcids":["https://orcid.org/0000-0002-3765-2067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralf Kuja-Halkola","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3765-2067","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078150015","display_name":"Shadi Azam","orcid":"https://orcid.org/0000-0002-3273-1970","observed_orcids":["https://orcid.org/0000-0002-3273-1970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shadi Azam","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3273-1970","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082372753","display_name":"Wei He","orcid":"https://orcid.org/0000-0003-0161-3274","observed_orcids":["https://orcid.org/0000-0003-0161-3274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei He","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053177403","display_name":"Per N Hall","orcid":"https://orcid.org/0000-0002-5640-9126","observed_orcids":["https://orcid.org/0000-0002-5640-9126"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Per Hall","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5640-9126","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040540995","display_name":"Kamila Czene","orcid":"https://orcid.org/0000-0002-3233-5695","observed_orcids":["https://orcid.org/0000-0002-3233-5695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamila Czene","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11361","display_name":"Digital Radiography and Breast Imaging","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11361","display_name":"Digital Radiography and Breast Imaging","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.8600000143051147},{"id":"https://openalex.org/keywords/breast-density","display_name":"breast density","score":0.9779999852180481},{"id":"https://openalex.org/keywords/microcalcifications","display_name":"microcalcifications","score":0.8690000176429749},{"id":"https://openalex.org/keywords/mammographic-masses","display_name":"mammographic masses","score":0.8389999866485596},{"id":"https://openalex.org/keywords/family-history-of-breast-cancer","display_name":"family history of breast cancer","score":0.8149999976158142},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.9959999918937683},{"id":"https://openalex.org/keywords/genetic-predisposition-to-breast-cancer","display_name":"genetic predisposition to breast cancer","score":0.9340000152587891},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.8512129783630371},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7854170799255371},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.6405739188194275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6222925186157227},{"id":"https://openalex.org/C2780472235","wikidata":"https://www.wikidata.org/wiki/Q324634","display_name":"Mammography","level":4,"score":0.5867369771003723},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4908748269081116},{"id":"https://openalex.org/C2909213482","wikidata":"https://www.wikidata.org/wiki/Q17011492","display_name":"MAMMOGRAPHIC DENSITY","level":5,"score":0.47753822803497314},{"id":"https://openalex.org/C169594400","wikidata":"https://www.wikidata.org/wiki/Q244775","display_name":"Twin study","level":3,"score":0.4696711003780365},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.4633050560951233},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4413473308086395},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41915470361709595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3996661305427551},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.33145755529403687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15554338693618774},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13568741083145142},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6512010","doi":"https://doi.org/10.1158/0008-5472.c.6512010","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6512010","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6512010","doi":"https://doi.org/10.1158/0008-5472.c.6512010","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6512010","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3015182308","https://openalex.org/W4362423612","https://openalex.org/W4362423535","https://openalex.org/W4361877682","https://openalex.org/W3016422465","https://openalex.org/W1526348192","https://openalex.org/W2166454331","https://openalex.org/W1549301930","https://openalex.org/W2090624356","https://openalex.org/W1986018993"],"abstract_inverted_index":{"Abstract":[0],"Mammographic":[1],"features":[2,19,68,94,216,242],"influence":[3,17],"breast":[4,31,64,76,155,181,220,232,251,273],"cancer":[5,32,65,77,156,182,221,274],"risk":[6,11,84,222,230,275],"and":[7,42,66,81,102,129,159,161,201,210,223,265,276],"are":[8,28,33,217,269],"used":[9],"in":[10,199],"prediction":[12],"models.":[13],"Understanding":[14],"how":[15],"genetics":[16],"mammographic":[18,39,67,93,241],"is":[20,243],"important":[21],"because":[22],"the":[23,50,57,206,248,260],"mechanisms":[24],"through":[25],"which":[26,268],"they":[27],"associated":[29,184,218,239,271],"with":[30,71,185,219,240,272],"not":[34],"well":[35],"known.":[36],"Here,":[37],"using":[38,109],"screening":[40],"history":[41,74,179],"detailed":[43],"questionnaire":[44],"data":[45,258],"from":[46,49],"56,820":[47],"women":[48,70,227,279],"KARMA":[51],"prospective":[52],"cohort":[53],"study,":[54],"we":[55,192],"investigated":[56],"association":[58,149],"between":[59,150],"a":[60,72,82,151,177],"genetic":[61,152],"predisposition":[62,153],"to":[63,146,154,245],"among":[69],"family":[73,178],"of":[75,92,180,197,205,208,231,236,250,262],"(N":[78],"=":[79,88],"49,674)":[80],"polygenic":[83],"score":[85],"(PRS,":[86],"N":[87],"9,365).":[89],"The":[90,134,148],"heritability":[91,136,198,204,261],"such":[95],"as":[96],"dense":[97],"area":[98],"(MD),":[99],"microcalcifications,":[100,128,263],"masses,":[101,264],"density":[103,266],"change":[104],"(MDC,":[105],"cm2/year)":[106],"was":[107,114,139,163,169,183],"estimated":[108,115,135],"1,940":[110],"sister":[111],"pairs.":[112],"Heritability":[113],"at":[116,212,228,280],"58%":[117],"[95%":[118],"confidence":[119],"interval":[120],"(CI),":[121],"48%\u201367%)":[122],"for":[123,127,132,137,166,174],"MD,":[124,200],"23%":[125],"(2%\u201345%)":[126],"13%":[130],"(1%\u201325%)]":[131],"masses.":[133],"MDC":[138],"essentially":[140],"null":[141],"(2%;":[142],"95%":[143],"CI,":[144],"\u22128%":[145],"12%).":[147],"(using":[157],"PRS)":[158],"MD":[160,188],"microcalcifications":[162,209],"positive,":[164],"while":[165],"masses":[167,211],"this":[168],"borderline":[170],"significant.":[171],"In":[172,190],"addition,":[173],"MDC,":[175],"having":[176],"slightly":[186],"greater":[187],"reduction.":[189],"summary,":[191],"have":[193],"confirmed":[194],"previous":[195],"findings":[196,255],"also":[202],"established":[203],"number":[207],"baseline.":[213],"Because":[214],"these":[215],"can":[224,277],"improve":[225],"detecting":[226],"short-term":[229,281],"cancer,":[233],"further":[234],"investigation":[235],"common":[237],"loci":[238],"warranted":[244],"better":[246],"understand":[247],"etiology":[249],"cancer.":[252],"Significance:":[253],"These":[254],"provide":[256],"novel":[257],"on":[259],"change,":[267],"all":[270],"indicate":[278],"risk.":[282]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-04-05T00:00:00"}