{"id":"https://openalex.org/W4361823256","doi":"https://doi.org/10.1158/0008-5472.c.6512085","title":"Data from Cancer-Induced Muscle Wasting Requires p38\u03b2 MAPK Activation of p300","display_name":"Data from Cancer-Induced Muscle Wasting Requires p38\u03b2 MAPK Activation of p300","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361823256","doi":"https://doi.org/10.1158/0008-5472.c.6512085"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6512085","doi":"https://doi.org/10.1158/0008-5472.c.6512085","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6512085","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6512085","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041443463","display_name":"Thomas K. Sin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas K. Sin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100339805","display_name":"Guohua Zhang","orcid":"https://orcid.org/0000-0003-3275-6905","observed_orcids":["https://orcid.org/0000-0003-3275-6905"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guohua Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101797194","display_name":"Zicheng Zhang","orcid":"https://orcid.org/0000-0002-9631-4316","observed_orcids":["https://orcid.org/0000-0002-9631-4316"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zicheng Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050537513","display_name":"James Z. Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Z. Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101436506","display_name":"Yan Zuo","orcid":"https://orcid.org/0009-0009-8341-5570","observed_orcids":["https://orcid.org/0009-0009-8341-5570"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Zuo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046674705","display_name":"Jeffrey A. Frost","orcid":"https://orcid.org/0000-0001-9722-1536","observed_orcids":["https://orcid.org/0000-0001-9722-1536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey A. Frost","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400752","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-7113-2700","observed_orcids":["https://orcid.org/0000-0002-7113-2700","https://orcid.org/0000-0002-5551-0134","https://orcid.org/0009-0008-7671-1462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100628291","display_name":"Yiping Li","orcid":"https://orcid.org/0000-0003-2188-6958","observed_orcids":["https://orcid.org/0000-0003-2188-6958"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-Ping Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.09120000153779984,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-cachexia","display_name":"cancer cachexia","score":0.8500000238418579},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nilotinib","display_name":"nilotinib","score":0.9120000004768372},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.6110000014305115},{"id":"https://openalex.org/keywords/skeletal-muscle-catabolism","display_name":"skeletal muscle catabolism","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-bearing-mice","display_name":"tumor-bearing mice","score":0.7200000286102295},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.7500849962234497},{"id":"https://openalex.org/C2777704314","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cachexia","level":3,"score":0.6830861568450928},{"id":"https://openalex.org/C2777413986","wikidata":"https://www.wikidata.org/wiki/Q412327","display_name":"Nilotinib","level":4,"score":0.6732093095779419},{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.6502161026000977},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5773345828056335},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5363553762435913},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5360947251319885},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5342124700546265},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5098323225975037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4379643499851227},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42412105202674866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40504947304725647},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36321932077407837},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3538212478160858},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2783380150794983},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17491140961647034},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12719079852104187},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.11159664392471313}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6512085","doi":"https://doi.org/10.1158/0008-5472.c.6512085","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6512085","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6512085","doi":"https://doi.org/10.1158/0008-5472.c.6512085","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6512085","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3116082743","https://openalex.org/W4361824834","https://openalex.org/W2912925714","https://openalex.org/W2144720369","https://openalex.org/W2896795033","https://openalex.org/W4225716520","https://openalex.org/W4415405576","https://openalex.org/W6979751934","https://openalex.org/W6983697259","https://openalex.org/W2350198083"],"abstract_inverted_index":{"Abstract":[0],"Cancer-associated":[1],"cachexia,":[2,198],"characterized":[3],"by":[4,27,190],"muscle":[5,25,80,94,124,152],"wasting,":[6,153],"is":[7,47,74,85],"a":[8,86,140,163,200],"lethal":[9],"metabolic":[10],"syndrome":[11],"without":[12,130],"defined":[13],"etiology":[14],"or":[15],"established":[16],"treatment.":[17],"We":[18],"previously":[19],"found":[20],"that":[21,40,52,103,182],"p300":[22,42,68,109,189],"mediates":[23],"cancer-induced":[24,54,93],"wasting":[26],"activating":[28],"C/EBP\u03b2,":[29],"which":[30,73],"then":[31],"upregulates":[32],"key":[33],"catabolic":[34],"genes.":[35],"However,":[36],"the":[37,115,191],"signaling":[38],"mechanism":[39],"activates":[41],"in":[43,60,127,146],"response":[44],"to":[45,69,78,161,171],"cancer":[46,122,168,197],"unknown.":[48],"Here,":[49],"we":[50],"show":[51],"upon":[53],"activation":[55,110,187],"of":[56,92,137,175,184,188],"Toll-like":[57],"receptor":[58],"4":[59],"skeletal":[61],"muscle,":[62],"p38\u03b2":[63,83,106,176,185],"MAPK":[64,84,117],"phosphorylates":[65],"Ser-12":[66],"on":[67],"stimulate":[70],"C/EBP\u03b2":[71],"acetylation,":[72],"necessary":[75],"and":[76,89,120],"sufficient":[77],"cause":[79],"wasting.":[81,95],"Thus,":[82],"central":[87],"mediator":[88],"therapeutic":[90,202],"target":[91],"In":[96],"addition,":[97],"nilotinib,":[98,195],"an":[99],"FDA-approved":[100,192],"kinase":[101,193],"inhibitor":[102],"preferentially":[104],"binds":[105],"MAPK,":[107],"inhibited":[108],"20-fold":[111],"more":[112],"potently":[113],"than":[114],"p38\u03b1/\u03b2":[116],"inhibitor,":[118,194],"SB202190,":[119],"abrogated":[121],"cell\u2013induced":[123],"protein":[125],"loss":[126],"C2C12":[128],"myotubes":[129],"suppressing":[131],"p38\u03b1":[132],"MAPK\u2013dependent":[133],"myogenesis.":[134],"Systemic":[135],"administration":[136],"nilotinib":[138,159],"at":[139],"low":[141],"dose":[142],"(0.5":[143],"mg/kg/day,":[144],"i.p.)":[145],"tumor-bearing":[147],"mice":[148],"not":[149],"only":[150],"alleviated":[151],"but":[154],"also":[155],"prolonged":[156],"survival.":[157],"Therefore,":[158],"appears":[160],"be":[162],"promising":[164],"treatment":[165],"for":[166],"human":[167],"cachexia":[169],"due":[170],"its":[172],"selective":[173],"inhibition":[174],"MAPK.":[177],"Significance:":[178],"These":[179],"findings":[180],"demonstrate":[181],"prevention":[183],"MAPK\u2013mediated":[186],"ameliorates":[196],"representing":[199],"potential":[201],"strategy":[203],"against":[204],"this":[205],"syndrome.":[206]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-05T00:00:00"}
