{"id":"https://openalex.org/W4361822927","doi":"https://doi.org/10.1158/0008-5472.c.6499989.v1","title":"Data from A Functional Receptor for B-Cell\u2013Activating Factor Is Expressed on Human Acute Lymphoblastic Leukemias","display_name":"Data from A Functional Receptor for B-Cell\u2013Activating Factor Is Expressed on Human Acute Lymphoblastic Leukemias","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361822927","doi":"https://doi.org/10.1158/0008-5472.c.6499989.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6499989.v1","doi":"https://doi.org/10.1158/0008-5472.c.6499989.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6499989.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6499989.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085253443","display_name":"Reshmi Parameswaran","orcid":"https://orcid.org/0000-0002-8043-7450","observed_orcids":["https://orcid.org/0000-0002-8043-7450"]},"institutions":[{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reshmi Parameswaran","raw_affiliation_strings":["Section of Molecular Carcinogenesis, Division of Hematology/Oncology and The Saban Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Molecular Carcinogenesis, Division of Hematology/Oncology and The Saban Research Institute and","institution_ids":["https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050087793","display_name":"Markus M\u00fcschen","orcid":"https://orcid.org/0000-0002-6064-8613","observed_orcids":["https://orcid.org/0000-0002-6064-8613"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus M\u00fcschen","raw_affiliation_strings":["Leukemia Research Program, Childrens Hospital Los Angeles;","Leukemia and Lymphoma Program, Norris Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Research Program, Childrens Hospital Los Angeles;","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Leukemia and Lymphoma Program, Norris Comprehensive Cancer Center","institution_ids":["https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065325837","display_name":"Yong\u2010Mi Kim","orcid":"https://orcid.org/0000-0003-3793-6438","observed_orcids":["https://orcid.org/0000-0003-3793-6438"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong-mi Kim","raw_affiliation_strings":["Departments of Pediatrics and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California","Leukemia Research Program, Childrens Hospital Los Angeles;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Leukemia Research Program, Childrens Hospital Los Angeles;","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060051979","display_name":"John Groffen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Groffen","raw_affiliation_strings":["Departments of Pediatrics and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California","Leukemia Research Program, Childrens Hospital Los Angeles;","Leukemia and Lymphoma Program, Norris Comprehensive Cancer Center","Section of Molecular Carcinogenesis, Division of Hematology/Oncology and The Saban Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Leukemia Research Program, Childrens Hospital Los Angeles;","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Leukemia and Lymphoma Program, Norris Comprehensive Cancer Center","institution_ids":["https://openalex.org/I4210117038"]},{"raw_affiliation_string":"Section of Molecular Carcinogenesis, Division of Hematology/Oncology and The Saban Research Institute and","institution_ids":["https://openalex.org/I4405270452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077589394","display_name":"Nora Heisterkamp","orcid":"https://orcid.org/0000-0003-2769-2273","observed_orcids":["https://orcid.org/0000-0003-2769-2273"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nora Heisterkamp","raw_affiliation_strings":["Departments of Pediatrics and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California","Leukemia Research Program, Childrens Hospital Los Angeles;","Leukemia and Lymphoma Program, Norris Comprehensive Cancer Center","Section of Molecular Carcinogenesis, Division of Hematology/Oncology and The Saban Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Leukemia Research Program, Childrens Hospital Los Angeles;","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Leukemia and Lymphoma Program, Norris Comprehensive Cancer Center","institution_ids":["https://openalex.org/I4210117038"]},{"raw_affiliation_string":"Section of Molecular Carcinogenesis, Division of Hematology/Oncology and The Saban Research Institute and","institution_ids":["https://openalex.org/I4405270452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5077589394"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4210117038","https://openalex.org/I4405270452"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-activating-factor","display_name":"B-cell activating factor","score":0.7329999804496765},{"id":"https://openalex.org/keywords/baff-receptor","display_name":"BAFF receptor","score":0.9539999961853027},{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.9419999718666077},{"id":"https://openalex.org/keywords/pre-b-cells","display_name":"pre-B cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/philadelphia-chromosome-positive-leukemia","display_name":"Philadelphia chromosome-positive leukemia","score":0.8579999804496765},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.828000009059906},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5730000138282776},{"id":"https://openalex.org/keywords/nilotinib","display_name":"nilotinib","score":0.9440000057220459},{"id":"https://openalex.org/keywords/leukemia-microenvironment","display_name":"leukemia microenvironment","score":0.7440000176429749},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C170286685","wikidata":"https://www.wikidata.org/wiki/Q409346","display_name":"B-cell activating factor","level":4,"score":0.9398839473724365},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5517569780349731},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4894953966140747},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4835629165172577},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.43128103017807007},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4017907381057739},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3711809515953064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3537830710411072},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.34077244997024536},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3140982389450073},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29315781593322754},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15881767868995667}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6499989.v1","doi":"https://doi.org/10.1158/0008-5472.c.6499989.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6499989.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6499989.v1","doi":"https://doi.org/10.1158/0008-5472.c.6499989.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6499989.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W37178407","https://openalex.org/W43972213","https://openalex.org/W1508958674","https://openalex.org/W1935116877","https://openalex.org/W1974607766","https://openalex.org/W1977996162","https://openalex.org/W1993803736","https://openalex.org/W1995025510","https://openalex.org/W1998439035","https://openalex.org/W2012751406","https://openalex.org/W2017682198","https://openalex.org/W2022900996","https://openalex.org/W2024372250","https://openalex.org/W2031077231","https://openalex.org/W2062123431","https://openalex.org/W2066616821","https://openalex.org/W2068355068","https://openalex.org/W2070135451","https://openalex.org/W2075862674","https://openalex.org/W2088446845","https://openalex.org/W2103591034","https://openalex.org/W2123172008","https://openalex.org/W2127436481","https://openalex.org/W2127971170","https://openalex.org/W2128198149","https://openalex.org/W2133534433","https://openalex.org/W2135668656","https://openalex.org/W2146392061","https://openalex.org/W2166022914","https://openalex.org/W2166397226","https://openalex.org/W2325203901","https://openalex.org/W2417349609","https://openalex.org/W4242397486"],"related_works":["https://openalex.org/W2024873697","https://openalex.org/W2566333442","https://openalex.org/W2035112667","https://openalex.org/W7098458607","https://openalex.org/W2950598379","https://openalex.org/W2214786374","https://openalex.org/W2570827801","https://openalex.org/W2079870022","https://openalex.org/W2167012225","https://openalex.org/W2123172008"],"abstract_inverted_index":{"Abstract":[0],"B-lineage":[1],"acute":[2],"lymphoblastic":[3],"leukemia":[4],"(ALL)":[5],"arises":[6],"by":[7,24,27,139,181],"transformation":[8],"of":[9,60,105,121,128,136,179,189],"a":[10,143],"progenitor":[11],"(pre-B)":[12],"cell.":[13],"Cure":[14],"rates":[15],"in":[16,77,125,159],"adults":[17],"remain":[18],"low":[19],"and":[20,50,58,63,83,103,112,130,154,185],"treatment":[21],"is":[22,173],"complicated":[23],"support":[25],"provided":[26],"the":[28,31,41,78,106,110,113,122,126,134,160,169,174,187],"microenvironment":[29],"to":[30,38,100,141,147],"leukemic":[32],"cells,":[33],"indicating":[34],"an":[35,194],"urgent":[36],"need":[37],"better":[39],"understand":[40],"factors":[42],"that":[43],"promote":[44],"their":[45],"survival.":[46],"B-cell\u2013activating":[47],"factor":[48],"(BAFF)":[49],"its":[51,191],"receptor":[52,107],"BAFF-R":[53,92,96,180],"are":[54,68],"important":[55],"for":[56,90],"survival":[57,120],"growth":[59],"mature":[61],"normal":[62],"malignant":[64],"B":[65],"cells":[66,76,124,162,184],"but":[67,163],"not":[69,166],"expressed":[70,158],"on":[71],"pre-B":[72,182],"cells.":[73],"Unexpectedly,":[74],"all":[75],"primary":[79],"Philadelphia":[80],"chromosome":[81],"(Ph)\u2013positive":[82],"Ph-negative":[84],"ALL":[85,123,183],"samples":[86],"tested":[87],"were":[88,156],"positive":[89],"high":[91],"cell":[93],"surface":[94],"expression.":[95],"was":[97,165],"fully":[98],"competent":[99],"bind":[101],"BAFF,":[102],"stimulation":[104],"activated":[108],"both":[109],"classic":[111],"noncanonical":[114],"NF-\u03baB":[115],"pathways.":[116],"Recombinant":[117],"BAFF":[118,152,164],"supported":[119],"absence":[127],"stroma,":[129],"it":[131],"significantly":[132],"attenuated":[133],"rate":[135],"apoptosis":[137],"caused":[138],"exposure":[140],"nilotinib,":[142],"drug":[144],"used":[145],"therapeutically":[146],"treat":[148],"Ph-positive":[149],"ALLs.":[150],"Surprisingly,":[151],"mRNA":[153],"protein":[155],"also":[157],"same":[161],"shed":[167],"into":[168],"medium.":[170],"Our":[171],"report":[172],"first":[175],"showing":[176],"universal":[177],"expression":[178],"opens":[186],"possibility":[188],"blocking":[190],"function":[192],"as":[193],"adjuvant":[195],"therapeutic":[196],"strategy.":[197],"Cancer":[198],"Res;":[199],"70(11);":[200],"4346\u201356.":[201],"\u00a92010":[202],"AACR.":[203]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
