{"id":"https://openalex.org/W4361822236","doi":"https://doi.org/10.1158/0008-5472.c.6499251.v1","title":"Data from Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer","display_name":"Data from Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361822236","doi":"https://doi.org/10.1158/0008-5472.c.6499251.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6499251.v1","doi":"https://doi.org/10.1158/0008-5472.c.6499251.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6499251.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6499251.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034589904","display_name":"Thiruvengadam Arumugam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thiruvengadam Arumugam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101698837","display_name":"Vijaya Ramachandran","orcid":"https://orcid.org/0000-0002-9717-9662","observed_orcids":["https://orcid.org/0000-0002-9717-9662"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vijaya Ramachandran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023336828","display_name":"Keith F. Fournier","orcid":"https://orcid.org/0000-0002-7882-9826","observed_orcids":["https://orcid.org/0000-0002-7882-9826"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith F. Fournier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101758546","display_name":"Huamin Wang","orcid":"https://orcid.org/0000-0002-2038-5863","observed_orcids":["https://orcid.org/0000-0002-2038-5863"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huamin Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068797950","display_name":"Lauren Marquis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lauren Marquis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087376683","display_name":"James L. Abbruzzese","orcid":"https://orcid.org/0000-0001-9223-2965","observed_orcids":["https://orcid.org/0000-0001-9223-2965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James L. Abbruzzese","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111690153","display_name":"Gary E. Gallick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary E. Gallick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028009560","display_name":"Craig D. Logsdon","orcid":"https://orcid.org/0000-0002-2214-1491","observed_orcids":["https://orcid.org/0000-0002-2214-1491"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Craig D. Logsdon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059536506","display_name":"David James McConkey","orcid":"https://orcid.org/0000-0003-1971-0638","observed_orcids":["https://orcid.org/0000-0003-1971-0638"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David J. McConkey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037573167","display_name":"Woonyoung Choi","orcid":"https://orcid.org/0000-0003-1088-9539","observed_orcids":["https://orcid.org/0000-0003-1088-9539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Woonyoung Choi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.38960000872612,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8769999742507935},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.796999990940094},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7850000262260437},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.8830000162124634},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":1.0},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9399999976158142},{"id":"https://openalex.org/keywords/zeb1","display_name":"ZEB1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.7379999756813049},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pancreatic-cancer-cell-lines","display_name":"pancreatic cancer cell lines","score":0.7289999723434448},{"id":"https://openalex.org/keywords/emt-reversal","display_name":"EMT reversal","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8501002788543701},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.7575345039367676},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.7436680793762207},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6248335838317871},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.578342616558075},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5536669492721558},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4850265383720398},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4430791139602661},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4399661123752594},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36669695377349854},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3493955135345459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3357246518135071},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3117963373661041},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30997365713119507},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.267146497964859},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20172074437141418},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15190884470939636},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1407242715358734}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6499251.v1","doi":"https://doi.org/10.1158/0008-5472.c.6499251.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6499251.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6499251.v1","doi":"https://doi.org/10.1158/0008-5472.c.6499251.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6499251.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2100751052","https://openalex.org/W2966064164","https://openalex.org/W2760480006","https://openalex.org/W2088915292","https://openalex.org/W1966934877","https://openalex.org/W2061876263","https://openalex.org/W2373015825","https://openalex.org/W4286631316","https://openalex.org/W3200169041","https://openalex.org/W3112564950"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"better":[2],"understanding":[3],"of":[4,22,34,95,101,170,189,199,218],"drug":[5,184,222],"resistance":[6,25,153,223],"mechanisms":[7,33],"is":[8],"required":[9],"to":[10,26,63,103,154,232],"improve":[11],"outcomes":[12],"in":[13,41,93,120,161,193,224],"patients":[14],"with":[15,31,152],"pancreatic":[16,42,137,226],"cancer.":[17],"Here,":[18],"we":[19],"characterized":[20],"patterns":[21],"sensitivity":[23],"and":[24,39,49,53,59,76,84,91,113,125,148,157,180,182,191,215,229,235],"three":[27,65],"conventional":[28],"chemotherapeutic":[29],"agents":[30,66],"divergent":[32],"action":[35],"[gemcitabine,":[36],"5-fluorouracil":[37],"(5-FU),":[38],"cisplatin]":[40],"cancer":[43,138,227],"cells.":[44],"Four":[45],"(L3.6pl,":[46],"BxPC-3,":[47],"CFPAC-1,":[48],"SU86.86)":[50],"were":[51,61],"sensitive":[52,83],"five":[54,135],"(PANC-1,":[55],"Hs766T,":[56],"AsPC-1,":[57],"MIAPaCa-2,":[58],"MPanc96)":[60],"resistant":[62,85],"all":[64],"based":[67],"on":[68],"GI50":[69],"(50%":[70],"growth":[71],"inhibition).":[72],"Gene":[73],"expression":[74,94,123,169,198],"profiling":[75],"unsupervised":[77],"hierarchical":[78],"clustering":[79],"revealed":[80],"that":[81,142,197,213],"the":[82,121,162,168,200],"cells":[86],"formed":[87],"two":[88,201],"distinct":[89],"groups":[90],"differed":[92],"specific":[96],"genes,":[97],"including":[98],"several":[99],"features":[100],"\u201cepithelial":[102],"mesenchymal":[104,163],"transition\u201d":[105],"(EMT).":[106],"Interestingly,":[107],"an":[108,143],"inverse":[109,144],"correlation":[110,145],"between":[111,146],"E-cadherin":[112,147,171,190],"its":[114],"transcriptional":[115],"suppressor,":[116],"Zeb-1,":[117],"was":[118,126,203],"observed":[119],"gene":[122],"data":[124],"confirmed":[127,141,196],"by":[128],"real-time":[129],"PCR.":[130],"Independent":[131],"validation":[132],"experiment":[133],"using":[134],"new":[136],"cell":[139],"lines":[140,164],"Zeb-1":[149,160,192,214,234],"correlated":[150],"closely":[151],"gemcitabine,":[155],"5-FU,":[156],"cisplatin.":[158],"Silencing":[159],"not":[165],"only":[166],"increased":[167],"but":[172],"also":[173],"other":[174,216],"epithelial":[175],"markers,":[176],"such":[177],"as":[178],"EVA1":[179],"MAL2,":[181],"restored":[183],"sensitivity.":[185],"Importantly,":[186],"immunohistochemical":[187],"analysis":[188],"primary":[194],"tumors":[195],"proteins":[202],"mutually":[204],"exclusive":[205],"(P":[206],"=":[207],"0.012).":[208],"Therefore,":[209],"our":[210],"results":[211],"suggest":[212],"regulators":[217],"EMT":[219,237],"may":[220],"maintain":[221],"human":[225],"cells,":[228],"therapeutic":[230],"strategies":[231],"inhibit":[233],"reverse":[236],"should":[238],"be":[239],"evaluated.":[240],"[Cancer":[241],"Res":[242],"2009;69(14):5820\u20138]":[243]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-05T00:00:00"}