{"id":"https://openalex.org/W4361821372","doi":"https://doi.org/10.1158/1055-9965.c.6514941","title":"Data from The Role of Genome Sequencing in Personalized Breast Cancer Prevention","display_name":"Data from The Role of Genome Sequencing in Personalized Breast Cancer Prevention","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361821372","doi":"https://doi.org/10.1158/1055-9965.c.6514941"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.c.6514941","doi":"https://doi.org/10.1158/1055-9965.c.6514941","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6514941","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1055-9965.c.6514941","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004680860","display_name":"Weiva Sieh","orcid":"https://orcid.org/0000-0003-0085-1190","observed_orcids":["https://orcid.org/0000-0003-0085-1190"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiva Sieh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108438886","display_name":"Joseph H. Rothstein","orcid":"https://orcid.org/0000-0002-8618-1660","observed_orcids":["https://orcid.org/0000-0002-8618-1660"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph H. Rothstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066514159","display_name":"Valerie M. McGuire","orcid":"https://orcid.org/0000-0002-9142-2086","observed_orcids":["https://orcid.org/0000-0002-9142-2086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valerie McGuire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037849512","display_name":"Alice S. Whittemore","orcid":"https://orcid.org/0000-0003-1985-9926","observed_orcids":["https://orcid.org/0000-0003-1985-9926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alice S. Whittemore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7609999775886536},{"id":"https://openalex.org/keywords/whole-genome-sequencing","display_name":"whole genome sequencing","score":0.7239999771118164},{"id":"https://openalex.org/keywords/personalized-cancer-prevention","display_name":"personalized cancer prevention","score":0.7049999833106995},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6269999742507935},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.49799999594688416},{"id":"https://openalex.org/keywords/monozygotic-twin-concordance","display_name":"monozygotic twin concordance","score":0.7950000166893005},{"id":"https://openalex.org/keywords/modifiable-risk-factors","display_name":"modifiable risk factors","score":0.6769999861717224},{"id":"https://openalex.org/keywords/screening-mammography","display_name":"mammography screening","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7816320657730103},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.6876099109649658},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.562684178352356},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5265610218048096},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4998011589050293},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.48049819469451904},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.46549925208091736},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4608983099460602},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33443617820739746},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3177069425582886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25863218307495117},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.12762042880058289}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1055-9965.c.6514941","doi":"https://doi.org/10.1158/1055-9965.c.6514941","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6514941","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.c.6514941","doi":"https://doi.org/10.1158/1055-9965.c.6514941","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6514941","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2156414576","https://openalex.org/W7096186415","https://openalex.org/W4300771131","https://openalex.org/W145052711","https://openalex.org/W2163183874","https://openalex.org/W2896293589","https://openalex.org/W4286561730","https://openalex.org/W2087638757","https://openalex.org/W2302420556","https://openalex.org/W2138234893"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"There":[2],"is":[3],"uncertainty":[4],"about":[5],"the":[6,18,40,62,76,85,98,135,139,157,223,233,241],"benefits":[7,41],"of":[8,44,56,68,79,87,100,105,138,146,222,226,235],"using":[9,236],"genome-wide":[10,237],"sequencing":[11,203,238],"to":[12,38,48,74,91,175,239],"implement":[13],"personalized":[14,195],"preventive":[15,46,89,198],"strategies":[16,124,199],"at":[17,52,93,186],"population":[19,50,77],"level,":[20],"with":[21,103,123,153,219],"some":[22],"projections":[23],"suggesting":[24],"little":[25],"benefit.":[26],"We":[27,60,96],"used":[28,61],"data":[29],"for":[30,184],"all":[31,147],"currently":[32],"known":[33,70,165],"breast":[34,57,71,80,116,149,196,227],"cancer":[35,72,81,117,150,197],"susceptibility":[36],"variants":[37,73],"assess":[39],"and":[42,65,83,122,160],"harms":[43],"targeting":[45,88],"efforts":[47,90],"a":[49,106,111],"subgroup":[51],"highest":[53,94,187],"genomic":[54],"risk":[55,112,129,140,178],"cancer.":[58,228],"Methods:":[59],"allele":[63],"frequencies":[64],"effect":[66],"sizes":[67],"86":[69],"estimate":[75],"distribution":[78,113,141],"risks":[82],"evaluate":[84],"strategy":[86,102,108,159],"those":[92,133,185],"risk.":[95,189],"compared":[97,152],"efficacy":[99],"this":[101],"that":[104,172,194],"\u201cbest-case\u201d":[107],"based":[109,125,162,200],"on":[110,126,163,201],"estimated":[114,128],"from":[115,246],"concordance":[118],"in":[119,134,208],"monozygous":[120],"twins,":[121],"previously":[127,164,212],"distributions.":[130],"Results:":[131],"Targeting":[132],"top":[136],"25%":[137],"would":[142,244],"include":[143],"approximately":[144],"half":[145],"future":[148],"cases,":[151],"70%":[154],"captured":[155],"by":[156],"best-case":[158],"35%":[161],"variants.":[166],"In":[167],"addition,":[168],"current":[169],"evidence":[170],"suggests":[171],"reducing":[173],"exposure":[174],"modifiable":[176],"nongenetic":[177],"factors":[179],"will":[180,204,217],"have":[181],"greatest":[182],"benefit":[183,245],"genetic":[188,224],"Conclusions:":[190],"These":[191,230],"estimates":[192],"suggest":[193],"genome":[202],"bring":[205],"greater":[206],"gains":[207,216],"disease":[209],"prevention":[210],"than":[211],"projected.":[213],"Moreover,":[214],"these":[215],"increase":[218],"increased":[220],"understanding":[221],"etiology":[225],"Impact:":[229],"results":[231],"support":[232],"feasibility":[234],"target":[240],"women":[242],"who":[243],"mammography":[247],"screening.":[248],"Cancer":[249],"Epidemiol":[250],"Biomarkers":[251],"Prev;":[252],"23(11);":[253],"2322\u20137.":[254],"\u00a92014":[255],"AACR.":[256]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2023-04-05T00:00:00"}