{"id":"https://openalex.org/W4361821163","doi":"https://doi.org/10.1158/1055-9965.c.6515037.v1","title":"Data from Association of Insulin-Related Serum Factors with Colorectal Polyp Number and Type in Adult Males","display_name":"Data from Association of Insulin-Related Serum Factors with Colorectal Polyp Number and Type in Adult Males","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361821163","doi":"https://doi.org/10.1158/1055-9965.c.6515037.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.c.6515037.v1","doi":"https://doi.org/10.1158/1055-9965.c.6515037.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6515037.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1055-9965.c.6515037.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061386610","display_name":"Sarah S. Comstock","orcid":"https://orcid.org/0000-0003-3107-7652","observed_orcids":["https://orcid.org/0000-0003-3107-7652"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah S. Comstock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Diana Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009248541","display_name":"Kari Hortos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kari Hortos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038888021","display_name":"Bruce Kovan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce Kovan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018510680","display_name":"Sarah McCaskey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah McCaskey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075053690","display_name":"Dorothy R. Pathak","orcid":"https://orcid.org/0000-0002-5318-3985","observed_orcids":["https://orcid.org/0000-0002-5318-3985"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dorothy R. Pathak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021488818","display_name":"Jenifer I. Fenton","orcid":"https://orcid.org/0000-0002-8875-3239","observed_orcids":["https://orcid.org/0000-0002-8875-3239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jenifer I. Fenton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0681999996304512,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.06589999794960022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-polyps","display_name":"colorectal polyps","score":0.9549999833106995},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.8109999895095825},{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.8289999961853027},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.6489999890327454},{"id":"https://openalex.org/keywords/soluble-receptor-for-advanced-glycation-end-products","display_name":"soluble receptor for advanced glycation end products","score":0.8920000195503235},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9599999785423279},{"id":"https://openalex.org/keywords/insulin-like-growth-factor","display_name":"insulin-like growth factor","score":0.921999990940094},{"id":"https://openalex.org/keywords/polyp-number","display_name":"polyp number","score":0.5299999713897705},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7120000123977661},{"id":"https://openalex.org/keywords/colonoscopy","display_name":"colonoscopy","score":0.6359999775886536},{"id":"https://openalex.org/keywords/colorectal-cancer-risk","display_name":"colorectal cancer risk","score":0.8220000267028809},{"id":"https://openalex.org/keywords/men","display_name":"men","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7931990623474121},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6485185027122498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6323781609535217},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.5598155856132507},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.49760130047798157},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.4938264787197113},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.49375876784324646},{"id":"https://openalex.org/C2776861080","wikidata":"https://www.wikidata.org/wiki/Q2825480","display_name":"Colorectal adenoma","level":4,"score":0.4721531867980957},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.46318578720092773},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4316478371620178},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.4234589636325836},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4118196368217468},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26755785942077637}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1055-9965.c.6515037.v1","doi":"https://doi.org/10.1158/1055-9965.c.6515037.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6515037.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.c.6515037.v1","doi":"https://doi.org/10.1158/1055-9965.c.6515037.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6515037.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2142681943","https://openalex.org/W7096379803","https://openalex.org/W2271837840","https://openalex.org/W2156111711","https://openalex.org/W2443927440","https://openalex.org/W2065096639","https://openalex.org/W2099469496","https://openalex.org/W2153051732","https://openalex.org/W2073533462","https://openalex.org/W2039176063"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Dysregulated":[2],"insulin":[3],"signaling":[4],"is":[5],"thought":[6],"to":[7,9,62,67,87,132,137,160,197,202,217],"contribute":[8],"cancer":[10],"risk.":[11],"Methods:":[12],"To":[13],"determine":[14],"if":[15],"insulin-related":[16],"serum":[17,52,175,187],"factors":[18],"are":[19],"associated":[20],"with":[21,51,72,109,115,141,143,171,173,185],"colon":[22],"polyps,":[23],"126":[24],"asymptomatic":[25],"men":[26,238],"(48\u201365":[27],"years)":[28],"were":[29,38,57,98,127,192],"recruited":[30],"at":[31],"colonoscopy.":[32,243],"Blood":[33],"was":[34,82,155,212],"collected.":[35],"Odds":[36],"ratios":[37],"determined":[39],"using":[40],"polytomous":[41],"logistic":[42],"regression":[43],"for":[44,118],"polyp":[45,69,110],"number":[46,111],"and":[47,233],"type.":[48,113],"Results:":[49],"Males":[50,114],"C-peptide":[53,73,77],"concentration":[54,124,181,189],">3.3":[55],"ng/mL":[56],"3.8":[58],"times":[59,84,129,157,194,214],"more":[60,85,195,215],"likely":[61,86,131,159,196,216],"have":[63,88,133,161,198,218],"an":[64,80,89],"adenoma":[65,90],"relative":[66,136,201],"no":[68,95,99,138,165,203,222],"than":[70,94,164,221],"those":[71],"\u22641.8":[74],"ng/mL.":[75],"As":[76,205],"tertile":[78,208],"increased,":[79,209],"individual":[81],"2":[83],"(P":[91,167,224],"=":[92,168,225],"0.01)":[93],"polyp.":[96],"There":[97],"associations":[100],"between":[101],"insulin-like":[102],"growth":[103,178],"factor":[104,179],"or":[105,112],"its":[106],"binding":[107],"proteins":[108],"soluble":[116],"receptor":[117],"advanced":[119],"glycation":[120],"end":[121],"products":[122],"(sRAGE)":[123],">120.4":[125],"pg/mL":[126,191],"0.25":[128],"less":[130,158],"\u22653":[134,162,199,219],"polyps":[135,139,163,166,200,220,223],"compared":[140],"males":[142,172,184],"sRAGE":[144,151],"\u226494.5":[145],"pg/mL.":[146],"For":[147],"each":[148],"increase":[149],"in":[150],"tertile,":[152],"a":[153,174,186,210],"man":[154,211],"0.5":[156],"0.03).":[169],"Compared":[170],"vascular":[176],"endothelial":[177],"(VEGF)":[180],"\u2264104.7":[182],"pg/mL,":[183],"VEGF":[188,207,234],">184.2":[190],"3.4":[193],"polyps.":[204],"the":[206,253],"1.9":[213],"0.049).":[226],"Conclusions:":[227],"Serum":[228],"concentrations":[229],"of":[230,246,255],"C-peptide,":[231],"sRAGE,":[232],"may":[235],"indicate":[236],"which":[237],"could":[239,248],"benefit":[240],"most":[241],"from":[242],"Impact:":[244],"Identification":[245],"biomarkers":[247],"reduce":[249],"medical":[250],"costs":[251],"through":[252],"elimination":[254],"colonoscopies":[256],"on":[257],"low-risk":[258],"individuals.":[259],"Cancer":[260],"Epidemiol":[261],"Biomarkers":[262],"Prev;":[263],"23(9);":[264],"1843\u201351.":[265],"\u00a92014":[266],"AACR.":[267]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-04-05T00:00:00"}
