{"id":"https://openalex.org/W4361821049","doi":"https://doi.org/10.1158/1055-9965.c.6515130","title":"Data from Analytic Variability in Immunohistochemistry Biomarker Studies","display_name":"Data from Analytic Variability in Immunohistochemistry Biomarker Studies","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361821049","doi":"https://doi.org/10.1158/1055-9965.c.6515130"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.c.6515130","doi":"https://doi.org/10.1158/1055-9965.c.6515130","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1055-9965.c.6515130","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1055-9965.c.6515130","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056510071","display_name":"Valsamo Anagnostou","orcid":"https://orcid.org/0000-0001-9480-3047","observed_orcids":["https://orcid.org/0000-0001-9480-3047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valsamo K. Anagnostou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044917183","display_name":"Allison Welsh","orcid":"https://orcid.org/0000-0002-4229-011X","observed_orcids":["https://orcid.org/0000-0002-4229-011X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allison W. Welsh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061348674","display_name":"Jennifer Margaret Giltnane","orcid":"https://orcid.org/0000-0002-8333-9995","observed_orcids":["https://orcid.org/0000-0002-8333-9995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer M. Giltnane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025189002","display_name":"Summar Siddiqui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Summar Siddiqui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016109869","display_name":"Camil Liceaga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camil Liceaga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110867767","display_name":"Mark D. Gustavson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Gustavson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106524954","display_name":"Konstantinos Nikolaos Syrigos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantinos N. Syrigos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085074001","display_name":"Jill L. Reiter","orcid":"https://orcid.org/0000-0001-5460-2355","observed_orcids":["https://orcid.org/0000-0001-5460-2355"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill L. Reiter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027326018","display_name":"David L. Rimm","orcid":"https://orcid.org/0000-0001-5820-4397","observed_orcids":["https://orcid.org/0000-0001-5820-4397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David L. Rimm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.05260000005364418,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.8410000205039978},{"id":"https://openalex.org/keywords/antibody-diversity","display_name":"antibody diversity","score":0.7310000061988831},{"id":"https://openalex.org/keywords/antibody-validation","display_name":"antibody validation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.640999972820282},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.8759999871253967},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9039999842643738},{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9470000267028809},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/quantitative-immunofluorescence","display_name":"quantitative immunofluorescence","score":0.8489999771118164},{"id":"https://openalex.org/keywords/antibody-clones","display_name":"antibody clones","score":0.3790000081062317},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8289999961853027},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"survival analysis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/quality-control","display_name":"quality control","score":0.7239999771118164},{"id":"https://openalex.org/keywords/antibody-specificity","display_name":"antibody specificity","score":0.367000013589859},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6944361925125122},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6461606621742249},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.49519267678260803},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.43549519777297974},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.41356921195983887},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40660378336906433},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3954886794090271},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3923954963684082},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.347960889339447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34310269355773926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27155476808547974},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24149343371391296}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1055-9965.c.6515130","doi":"https://doi.org/10.1158/1055-9965.c.6515130","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1055-9965.c.6515130","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.c.6515130","doi":"https://doi.org/10.1158/1055-9965.c.6515130","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1055-9965.c.6515130","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2129597559","https://openalex.org/W1969009220","https://openalex.org/W2030701312","https://openalex.org/W2074395681","https://openalex.org/W2075371626","https://openalex.org/W2734602083","https://openalex.org/W2060966049","https://openalex.org/W4415903241","https://openalex.org/W2072228651","https://openalex.org/W2977883234"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Despite":[2],"the":[3,23,30,110,252,261],"widespread":[4],"use":[5,111],"of":[6,25,32,112,236,254,263],"immunohistochemistry":[7],"(IHC),":[8],"there":[9],"are":[10,242],"no":[11,204],"standardization":[12,256],"guidelines":[13],"that":[14,228],"control":[15,241],"for":[16],"antibody":[17,27],"probe":[18],"variability.":[19],"Here":[20],"we":[21],"describe":[22],"effect":[24],"variable":[26],"reagents":[28],"in":[29,83,100,141,154,232,260],"assessment":[31],"cancer-related":[33],"biomarkers":[34],"by":[35,57,91,213],"IHC.":[36],"Methods:":[37],"Estrogen":[38],"receptor":[39,44,52],"(ER),":[40],"epidermal":[41,49],"growth":[42,50],"factor":[43,51,227],"(EGFR)":[45],"1,":[46],"and":[47,67,69,75,77,97,135,143,160,176,198,210,239,257],"human":[48],"3":[53],"(HER3)":[54],"were":[55,81,125,162],"evaluated":[56],"quantitative":[58],"immunofluorescence.":[59],"Correlations":[60],"between":[61,208],"ER":[62,123],"clones":[63],"1D5,":[64],"SP1,":[65],"F10,":[66],"ER60c,":[68],"EGFR":[70,147,186,211],"monoclonal":[71],"31G7,":[72],"2-18C9,":[73,214],"H11,":[74],"15F8,":[76,215],"polyclonal":[78,217],"2232":[79,150,218],"antibodies":[80,99,124,148],"assessed":[82],"642":[84],"breast":[85],"cancer":[86,103],"patients.":[87,104],"HER3":[88,172],"was":[89,107,174,187,203],"measured":[90,188],"RTJ1,":[92],"RTJ2,":[93],"SGP1,":[94],"M7297,":[95],"RB-9211,":[96],"C-17":[98],"42":[101],"lung":[102],"Survival":[105],"analysis":[106],"done":[108],"with":[109,189],"multiple":[113],"cutoff":[114],"points":[115],"to":[116],"reveal":[117],"any":[118],"prognostic":[119],"classification.":[120],"Results:":[121],"All":[122,146],"tightly":[126],"correlated":[127],"(Pearson's":[128,165],"r2":[129,166],"=":[130,167,196,200],"0.94-0.96;":[131],"P":[132,169,195,199],"<":[133,170],"0.0001)":[134],"western":[136,155],"blotting":[137],"confirmed":[138],"their":[139],"specificity":[140],"MCF-7":[142],"BT474":[144],"cells.":[145],"but":[149],"yielded":[151],"specific":[152],"results":[153],"blotting;":[156],"however,":[157],"only":[158],"31G7":[159,192],"2-18C9":[161],"strongly":[163],"associated":[164],"0.61;":[168],"0.0001).":[171],"staining":[173],"nonspecific":[175],"nonreproducible.":[177],"High":[178],"EGFR\u2013expressing":[179],"patients":[180],"had":[181],"a":[182,224],"worse":[183],"prognosis":[184],"when":[185],"H11":[190],"or":[191,216],"(log":[193],"rank":[194],"0.015":[197],"0.06).":[201],"There":[202],"statistically":[205],"significant":[206],"correlation":[207],"survival":[209],"detected":[212],"antibodies.":[219],"Conclusions:":[220],"Antibody":[221],"validation":[222],"is":[223],"critical":[225],"analytic":[226],"regulates":[229],"IHC":[230,237,246,255,266],"readings":[231],"biomarker":[233],"studies.":[234],"Evaluation":[235],"proficiency":[238],"quality":[240],"key":[243],"components":[244],"toward":[245],"standardization.":[247],"Impact:":[248],"This":[249],"work":[250],"highlights":[251],"importance":[253],"could":[258],"result":[259],"improvement":[262],"clinically":[264],"relevant":[265],"protocols.":[267],"Cancer":[268],"Epidemiol":[269],"Biomarkers":[270],"Prev;":[271],"19(4);":[272],"982\u201391.":[273],"\u00a92010":[274],"AACR.":[275]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
