{"id":"https://openalex.org/W4361820692","doi":"https://doi.org/10.1158/1055-9965.c.6515199","title":"Data from A Common Prostate Cancer Risk Variant 5\u2032 of Microseminoprotein-\u03b2 (MSMB) Is a Strong Predictor of Circulating \u03b2-Microseminoprotein (MSP) Levels in Multiple Populations","display_name":"Data from A Common Prostate Cancer Risk Variant 5\u2032 of Microseminoprotein-\u03b2 (MSMB) Is a Strong Predictor of Circulating \u03b2-Microseminoprotein (MSP) Levels in Multiple Populations","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361820692","doi":"https://doi.org/10.1158/1055-9965.c.6515199"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.c.6515199","doi":"https://doi.org/10.1158/1055-9965.c.6515199","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1055-9965.c.6515199","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1055-9965.c.6515199","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063828775","display_name":"Kevin M. Waters","orcid":"https://orcid.org/0000-0003-2140-3514","observed_orcids":["https://orcid.org/0000-0003-2140-3514"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin M. Waters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046710077","display_name":"Daniel O. Stram","orcid":"https://orcid.org/0000-0001-7099-9022","observed_orcids":["https://orcid.org/0000-0001-7099-9022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel O. Stram","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053074659","display_name":"Lo\u0131\u0308c Le Marchand","orcid":"https://orcid.org/0000-0001-5013-980X","observed_orcids":["https://orcid.org/0000-0001-5013-980X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Loic Le Marchand","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015132763","display_name":"Robert J. Klein","orcid":"https://orcid.org/0000-0003-3539-5391","observed_orcids":["https://orcid.org/0000-0003-3539-5391"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert J. Klein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064149395","display_name":"Camilla Valtonen\u2010Andr\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camilla Valtonen-Andr\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068834945","display_name":"Mari T. Peltola","orcid":"https://orcid.org/0000-0002-8615-0231","observed_orcids":["https://orcid.org/0000-0002-8615-0231"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mari T. Peltola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104546118","display_name":"Laurence N. Kolonel","orcid":"https://orcid.org/0000-0002-2246-1970","observed_orcids":["https://orcid.org/0000-0002-2246-1970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurence N. Kolonel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111890042","display_name":"Brian E. Henderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian E. Henderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056770711","display_name":"Hans G. Lilja","orcid":"https://orcid.org/0000-0001-5871-7846","observed_orcids":["https://orcid.org/0000-0001-5871-7846"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans Lilja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063459619","display_name":"Christopher A. Haiman","orcid":"https://orcid.org/0000-0002-0097-9971","observed_orcids":["https://orcid.org/0000-0002-0097-9971"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher A. Haiman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.14059999585151672,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.09220000356435776,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-microseminoprotein","display_name":"beta-microseminoprotein","score":0.8790000081062317},{"id":"https://openalex.org/keywords/msmb","display_name":"MSMB","score":0.9160000085830688},{"id":"https://openalex.org/keywords/prostate-cancer-risk","display_name":"prostate cancer risk","score":0.7400000095367432},{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.7039999961853027},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.5770000219345093},{"id":"https://openalex.org/keywords/plasma-protein-levels","display_name":"plasma protein levels","score":0.703000009059906},{"id":"https://openalex.org/keywords/racial-and-ethnic-differences","display_name":"racial and ethnic differences","score":0.7540000081062317},{"id":"https://openalex.org/keywords/multiethnic-cohort","display_name":"multi-ethnic cohort","score":0.8619999885559082},{"id":"https://openalex.org/keywords/prostate-cancer-risk-prediction","display_name":"prostate cancer risk prediction","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6912441849708557},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6580917835235596},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5106533169746399},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4976518452167511},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4714204668998718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4254567325115204},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3834460377693176},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3796914517879486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36253273487091064},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33780938386917114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3103709816932678},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1055-9965.c.6515199","doi":"https://doi.org/10.1158/1055-9965.c.6515199","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1055-9965.c.6515199","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1055-9965.c.6515199.v1","doi":"https://doi.org/10.1158/1055-9965.c.6515199.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6515199.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.c.6515199","doi":"https://doi.org/10.1158/1055-9965.c.6515199","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1055-9965.c.6515199","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2108556325","https://openalex.org/W2143025126","https://openalex.org/W7095106236","https://openalex.org/W4361863449","https://openalex.org/W2142313231","https://openalex.org/W2751740351","https://openalex.org/W2160713126","https://openalex.org/W1955763621","https://openalex.org/W4300664283","https://openalex.org/W3013760378"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"\u03b2-Microseminoprotein":[2],"(MSP)":[3],"is":[4,200],"one":[5],"of":[6,13,35,67,124,158],"the":[7,14,32,36,56,77,95,125,151,159,214,220],"three":[8],"most":[9],"abundantly":[10],"secreted":[11],"proteins":[12],"prostate":[15,24,51,69],"and":[16,61,85,100,111,145,192],"has":[17,42],"been":[18,44],"suggested":[19],"as":[20,46],"a":[21,47,65],"biomarker":[22],"for":[23,50,154],"cancer":[25],"risk.":[26],"A":[27],"common":[28],"variant,":[29],"rs10993994,":[30],"in":[31,64,76,114,161,164,172,189,194,207],"5\u2032":[33],"region":[34],"gene":[37],"that":[38,216],"encodes":[39],"MSP":[40,62,101,112,132,162,173,183,205],"(MSMB)":[41],"recently":[43],"identified":[45],"risk":[48],"factor":[49],"cancer.":[52],"Methods:":[53],"We":[54,104,149,167],"examined":[55],"association":[57,96],"between":[58,97,108,175],"rs10993994":[59,98,217],"genotype":[60,99,110,199],"levels":[63,113,133,163,174,184,206],"sample":[66],"500":[68],"cancer\u2013free":[70],"men":[71],"from":[72],"four":[73],"racial/ethnic":[74,116,209],"populations":[75,176],"Multiethnic":[78],"Cohort":[79],"(European":[80],"Americans,":[81,83,138,141,147],"African":[82,140,190],"Latinos,":[84,143],"Japanese":[86,146,195],"Americans).":[87],"Generalized":[88],"linear":[89],"models":[90],"were":[91],"used":[92],"to":[93,156,186],"estimate":[94],"levels.":[102],"Results:":[103],"observed":[105,169,185],"robust":[106],"associations":[107],"rs10994994":[109],"each":[115,165],"population":[117],"(all":[118],"P":[119],"<":[120],"10\u22128),":[121],"with":[122,182,203],"carriers":[123],"C":[126],"allele":[127],"having":[128],"lower":[129],"geometric":[130],"mean":[131],"(ng/mL;":[134],"CC/CT/TT":[135],"genotypes:":[136],"European":[137],"28.8/20.9/10.0;":[139],"29.0/21.9/10.9;":[142],"29.2/17.1/8.3;":[144],"25.8/16.4/6.7).":[148],"estimated":[150],"variant":[152],"accounts":[153],"30%":[155],"50%":[157],"variation":[160],"population.":[166],"also":[168],"significant":[170],"differences":[171],"(P":[177],"=":[178],"3.5":[179],"\u00d7":[180],"10\u22126),":[181],"be":[187,219],"highest":[188],"Americans":[191],"lowest":[193],"Americans.":[196],"Conclusions:":[197],"Rs10993994":[198],"strongly":[201],"associated":[202],"plasma":[204],"multiple":[208],"populations.":[210],"Impact:":[211],"This":[212],"supports":[213],"hypothesis":[215],"may":[218],"biologically":[221],"functional":[222],"allele.":[223],"Cancer":[224],"Epidemiol":[225],"Biomarkers":[226],"Prev;":[227],"19(10);":[228],"2639\u201346.":[229],"\u00a92010":[230],"AACR.":[231]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
