{"id":"https://openalex.org/W4361820690","doi":"https://doi.org/10.1158/1055-9965.c.6515253","title":"Data from Pathway Analyses Identify TGFBR2 as Potential Breast Cancer Susceptibility Gene: Results from a Consortium Study among Asians","display_name":"Data from Pathway Analyses Identify TGFBR2 as Potential Breast Cancer Susceptibility Gene: Results from a Consortium Study among Asians","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361820690","doi":"https://doi.org/10.1158/1055-9965.c.6515253"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.c.6515253","doi":"https://doi.org/10.1158/1055-9965.c.6515253","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1055-9965.c.6515253","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1055-9965.c.6515253","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100775558","display_name":"Xiangyu Ma","orcid":"https://orcid.org/0000-0001-7967-3950","observed_orcids":["https://orcid.org/0000-0001-7967-3950","https://orcid.org/0009-0003-8497-256X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiangyu Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043613592","display_name":"Alicia C. Beeghly-Fadiel","orcid":"https://orcid.org/0000-0001-9913-732X","observed_orcids":["https://orcid.org/0000-0001-9913-732X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alicia Beeghly-Fadiel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058202082","display_name":"Jiajun Shi","orcid":"https://orcid.org/0000-0001-5194-0009","observed_orcids":["https://orcid.org/0000-0001-5194-0009"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiajun Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057973374","display_name":"Yong\u2010Bing Xiang","orcid":"https://orcid.org/0000-0002-3840-9915","observed_orcids":["https://orcid.org/0000-0002-3840-9915"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-Bing Xiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005513706","display_name":"Qiuyin Cai","orcid":"https://orcid.org/0000-0002-9384-5648","observed_orcids":["https://orcid.org/0000-0002-9384-5648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiuyin Cai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001453048","display_name":"Hongbing Shen","orcid":"https://orcid.org/0000-0002-2581-5906","observed_orcids":["https://orcid.org/0000-0002-2581-5906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongbing Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006076332","display_name":"Chen\u2010Yang Shen","orcid":"https://orcid.org/0000-0001-5555-9950","observed_orcids":["https://orcid.org/0000-0001-5555-9950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen-Yang Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021226699","display_name":"Zefang Ren","orcid":"https://orcid.org/0000-0002-7785-4704","observed_orcids":["https://orcid.org/0000-0002-7785-4704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zefang Ren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066277266","display_name":"Keitaro Matsuo","orcid":"https://orcid.org/0000-0003-1761-6314","observed_orcids":["https://orcid.org/0000-0003-1761-6314"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keitaro Matsuo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041325189","display_name":"US Khoo","orcid":"https://orcid.org/0000-0003-2200-7505","observed_orcids":["https://orcid.org/0000-0003-2200-7505"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ui Soon Khoo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026285947","display_name":"Motoki Iwasaki","orcid":"https://orcid.org/0000-0003-3319-4131","observed_orcids":["https://orcid.org/0000-0003-3319-4131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Motoki Iwasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101592761","display_name":"Jirong Long","orcid":"https://orcid.org/0000-0002-7433-9766","observed_orcids":["https://orcid.org/0000-0002-7433-9766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jirong Long","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100700607","display_name":"Ben Zhang","orcid":"https://orcid.org/0000-0002-4972-5171","observed_orcids":["https://orcid.org/0000-0002-4972-5171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ben Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054987837","display_name":"Bu\u2010Tian Ji","orcid":"https://orcid.org/0000-0002-8000-4997","observed_orcids":["https://orcid.org/0000-0002-8000-4997"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bu-Tian Ji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117594156","display_name":"Ying Zheng","orcid":"https://orcid.org/0000-0002-5264-6431","observed_orcids":["https://orcid.org/0000-0002-5264-6431","https://orcid.org/0009-0006-8899-1495"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Zheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100429465","display_name":"Wenjing Wang","orcid":"https://orcid.org/0000-0002-4527-1168","observed_orcids":["https://orcid.org/0000-0002-4527-1168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenjing Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084213516","display_name":"Zhibin Hu","orcid":"https://orcid.org/0000-0002-8277-5234","observed_orcids":["https://orcid.org/0000-0002-8277-5234"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhibin Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100463062","display_name":"Yao Liu","orcid":"https://orcid.org/0000-0001-6750-9950","observed_orcids":["https://orcid.org/0000-0001-6750-9950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yao Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068032182","display_name":"Pei\u2010Ei Wu","orcid":"https://orcid.org/0009-0008-3477-3841","observed_orcids":["https://orcid.org/0009-0008-3477-3841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pei-Ei Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004018665","display_name":"Ya-Lan Shieh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya-Lan Shieh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101583630","display_name":"Shenming Wang","orcid":"https://orcid.org/0000-0003-1058-484X","observed_orcids":["https://orcid.org/0000-0003-1058-484X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shenming Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaoming Xie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoming Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037334743","display_name":"Hidemi M. Ito","orcid":"https://orcid.org/0000-0002-8023-4581","observed_orcids":["https://orcid.org/0000-0002-8023-4581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hidemi Ito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110397616","display_name":"Yoshio Kasuga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshio Kasuga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084506944","display_name":"Kelvin Y.K. Chan","orcid":"https://orcid.org/0000-0002-5272-0005","observed_orcids":["https://orcid.org/0000-0002-5272-0005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelvin Y.K. Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008549101","display_name":"Hiroji Iwata","orcid":"https://orcid.org/0000-0002-0242-4718","observed_orcids":["https://orcid.org/0000-0002-0242-4718"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroji Iwata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047713366","display_name":"Shoichiro Tsugane","orcid":"https://orcid.org/0000-0003-4105-2774","observed_orcids":["https://orcid.org/0000-0003-4105-2774"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shoichiro Tsugane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080361653","display_name":"Yu\u2010Tang Gao","orcid":"https://orcid.org/0000-0003-3904-1777","observed_orcids":["https://orcid.org/0000-0003-3904-1777"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-Tang Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045077450","display_name":"Xiao Ou Shu","orcid":"https://orcid.org/0000-0002-1053-1353","observed_orcids":["https://orcid.org/0000-0002-1053-1353"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao Ou Shu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045030798","display_name":"Harold L. Moses","orcid":"https://orcid.org/0000-0002-0116-0140","observed_orcids":["https://orcid.org/0000-0002-0116-0140"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harold L. Moses","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100401143","display_name":"Wei Zheng","orcid":"https://orcid.org/0000-0003-1226-070X","observed_orcids":["https://orcid.org/0000-0003-1226-070X","https://orcid.org/0000-0003-1034-0757","https://orcid.org/0009-0008-5993-0647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Zheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.06440000236034393,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-susceptibility","display_name":"breast cancer susceptibility","score":0.8539999723434448},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9539999961853027},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9359999895095825},{"id":"https://openalex.org/keywords/asian-women","display_name":"Asian women","score":0.6539999842643738},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.656000018119812},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.5720000267028809},{"id":"https://openalex.org/keywords/pathway-analysis","display_name":"pathway analysis","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8021559715270996},{"id":"https://openalex.org/C157410074","wikidata":"https://www.wikidata.org/wiki/Q6869145","display_name":"Minor allele frequency","level":5,"score":0.7080180048942566},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6489190459251404},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.498396635055542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49784421920776367},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.462069571018219},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4553842842578888},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.45421066880226135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44247886538505554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3823963701725006},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.380341500043869},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36390823125839233},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3074520528316498}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1055-9965.c.6515253","doi":"https://doi.org/10.1158/1055-9965.c.6515253","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1055-9965.c.6515253","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1055-9965.c.6515253.v1","doi":"https://doi.org/10.1158/1055-9965.c.6515253.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6515253.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.c.6515253","doi":"https://doi.org/10.1158/1055-9965.c.6515253","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1055-9965.c.6515253","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2170349505","https://openalex.org/W1985557256","https://openalex.org/W2250127326","https://openalex.org/W1658080127","https://openalex.org/W2322409179","https://openalex.org/W2600026186","https://openalex.org/W2032427570","https://openalex.org/W2158244150","https://openalex.org/W2316226435","https://openalex.org/W3007812830"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"The":[2],"TGF-\u03b2":[3,26,215],"signaling":[4,27,216],"pathway":[5,28,217],"plays":[6],"a":[7,35,69,179,208],"significant":[8,109],"role":[9,209],"in":[10,25,117,127,156,214,220,222],"the":[11,44,72,80,99,142,157,234],"carcinogenic":[12],"process":[13],"of":[14,22,71,166,175,183,236],"breast":[15,31,112,184,223,237],"cancer.":[16],"Methods:":[17],"We":[18],"systematically":[19],"evaluated":[20,60,89],"associations":[21,87,110],"common":[23,211],"variants":[24],"genes":[29,58],"with":[30,50,85,111,187],"cancer":[32,113,185,224,238],"risk":[33,114,182],"using":[34],"multistage,":[36],"case\u2013control":[37],"study":[38,119],"among":[39,61,90,115,135,147],"Asian":[40,158],"women.":[41],"Results:":[42],"In":[43,79],"first":[45],"stage,":[46,82],"341":[47],"single-nucleotide":[48],"polymorphisms":[49],"minor":[51,171],"allele":[52,172,189],"frequencies":[53],"\u2265":[54],"0.05":[55],"across":[56],"11":[57],"were":[59,88],"2,926":[62],"cases":[63,94,137,149],"and":[64,95,108,138,150],"2,380":[65],"controls":[66,97,140,152],"recruited":[67],"as":[68,121,123,144,146,239,241],"part":[70],"Shanghai":[73],"Breast":[74,159],"Cancer":[75,160,246],"Genetics":[76],"Study":[77],"(SBCGS).":[78],"second":[81],"20":[83],"SNPs":[84],"promising":[86,124],"an":[91],"additional":[92],"1,890":[93],"2,000":[96],"from":[98,126,141,153],"SBCGS.":[100],"One":[101],"variant,":[102],"TGFBR2":[103,176],"rs1078985,":[104],"had":[105,178],"highly":[106],"consistent":[107],"participants":[116],"both":[118],"stages,":[120],"well":[122,145,240],"results":[125],"silico":[128],"analysis.":[129],"Additional":[130],"genotyping":[131],"was":[132],"carried":[133],"out":[134],"2,475":[136],"2,343":[139],"SBCGS,":[143],"5,077":[148],"5,384":[151],"six":[154],"studies":[155],"Consortium":[161],"(stage":[162],"III).":[163],"Pooled":[164],"analysis":[165],"all":[167],"data":[168],"indicated":[169],"that":[170],"homozygotes":[173],"(GG)":[174],"rs1078985":[177],"24%":[180],"reduced":[181],"compared":[186],"major":[188],"carriers":[190],"(AG":[191],"or":[192],"AA;":[193],"OR,":[194],"0.76;":[195],"95%":[196],"CI,":[197],"0.65\u20130.89;":[198],"P":[199],"=":[200],"8.42":[201],"\u00d7":[202],"10\u22124).":[203],"Conclusion:":[204],"These":[205,227],"findings":[206,228],"support":[207],"for":[210],"genetic":[212],"variation":[213],"genes,":[218],"specifically":[219],"TGFBR2,":[221],"susceptibility.":[225],"Impact:":[226],"may":[229],"provide":[230],"new":[231],"insights":[232],"into":[233],"etiology":[235],"future":[242],"potential":[243],"therapeutic":[244],"targets.":[245],"Epidemiol":[247],"Biomarkers":[248],"Prev;":[249],"21(7);":[250],"1176\u201384.":[251],"\u00a92012":[252],"AACR.":[253]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}