{"id":"https://openalex.org/W4361820570","doi":"https://doi.org/10.1158/0008-5472.22414770.v1","title":"Figure S6 from \u03b2-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy","display_name":"Figure S6 from \u03b2-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361820570","doi":"https://doi.org/10.1158/0008-5472.22414770.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22414770.v1","doi":"https://doi.org/10.1158/0008-5472.22414770.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22414770.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22414770.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078984239","display_name":"Mark J. Bucsek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark J. Bucsek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079666362","display_name":"Guanxi Qiao","orcid":"https://orcid.org/0000-0002-7340-7077","observed_orcids":["https://orcid.org/0000-0002-7340-7077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guanxi Qiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036102637","display_name":"Cameron R. MacDonald","orcid":"https://orcid.org/0000-0002-7402-7113","observed_orcids":["https://orcid.org/0000-0002-7402-7113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cameron R. MacDonald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016454018","display_name":"Thejaswini Giridharan","orcid":"https://orcid.org/0000-0003-0512-577X","observed_orcids":["https://orcid.org/0000-0003-0512-577X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thejaswini Giridharan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lauren Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lauren Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080242259","display_name":"Brian Niedzwecki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Niedzwecki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100782472","display_name":"Haichao Liu","orcid":"https://orcid.org/0000-0001-6866-1284","observed_orcids":["https://orcid.org/0000-0001-6866-1284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haichao Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019688706","display_name":"Kathleen M. Kokolus","orcid":"https://orcid.org/0000-0002-9088-5409","observed_orcids":["https://orcid.org/0000-0002-9088-5409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathleen M. Kokolus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066978332","display_name":"Jason W.\u2010L. Eng","orcid":"https://orcid.org/0000-0002-8219-2290","observed_orcids":["https://orcid.org/0000-0002-8219-2290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason W.-L. Eng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058177760","display_name":"Michelle Nicole Messmer","orcid":"https://orcid.org/0000-0002-7597-8615","observed_orcids":["https://orcid.org/0000-0002-7597-8615"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle N. Messmer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011054139","display_name":"Kristopher M. Attwood","orcid":"https://orcid.org/0000-0002-7229-5472","observed_orcids":["https://orcid.org/0000-0002-7229-5472","https://orcid.org/0009-0003-3874-1293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristopher Attwood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058401562","display_name":"Scott I. Abrams","orcid":"https://orcid.org/0000-0002-8742-4708","observed_orcids":["https://orcid.org/0000-0002-8742-4708"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott I. Abrams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085199635","display_name":"Bonnie Lee Hylander","orcid":"https://orcid.org/0000-0002-0836-1893","observed_orcids":["https://orcid.org/0000-0002-0836-1893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bonnie L. Hylander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029344793","display_name":"Elizabeth A. Repasky","orcid":"https://orcid.org/0000-0002-9554-4152","observed_orcids":["https://orcid.org/0000-0002-9554-4152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth A. Repasky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-signaling","display_name":"beta-adrenergic signaling","score":0.968999981880188},{"id":"https://openalex.org/keywords/housing-temperature","display_name":"housing temperature","score":0.871999979019165},{"id":"https://openalex.org/keywords/cold-housing","display_name":"cold housing","score":0.5339999794960022},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.6990000009536743},{"id":"https://openalex.org/keywords/anti-pd-1-antibody","display_name":"anti-PD-1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/4t1-breast-cancer-model","display_name":"4T1 breast cancer","score":0.7200000286102295},{"id":"https://openalex.org/keywords/b16-ova-melanoma","display_name":"B16-OVA melanoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/effector-t-cells","display_name":"effector T cells","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7409567832946777},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6242414116859436},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5692550539970398},{"id":"https://openalex.org/C6425155","wikidata":"https://www.wikidata.org/wiki/Q25267","display_name":"Degree Celsius","level":2,"score":0.5126037001609802},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44472160935401917},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38254255056381226},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35535794496536255},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3395536243915558},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30777764320373535},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2723115086555481},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18265792727470398},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15925395488739014},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14802178740501404},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10535761713981628},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.22414770.v1","doi":"https://doi.org/10.1158/0008-5472.22414770.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22414770.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22414770.v1","doi":"https://doi.org/10.1158/0008-5472.22414770.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22414770.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362348241","https://openalex.org/W4362350961","https://openalex.org/W4362348238","https://openalex.org/W4362446375","https://openalex.org/W4361824101","https://openalex.org/W2748524892","https://openalex.org/W4362421796","https://openalex.org/W2612917229","https://openalex.org/W4362421807","https://openalex.org/W2003173977"],"abstract_inverted_index":{"This":[0],"data":[1],"shows":[2],"that":[3,23],"housing":[4,25],"mice":[5,21],"at":[6],"30":[7],"degrees":[8,28],"Celsius":[9],"improves":[10],"the":[11,31],"efficacy":[12,32],"of":[13,33],"anti-PD-1":[14,34],"in":[15,35],"both":[16],"4T1":[17],"and":[18],"B16-OVA":[19],"tumor-bearing":[20],"indicating":[22],"cool":[24],"temperatures":[26],"(22":[27],"C)":[29],"impairs":[30],"murine":[36],"tumor":[37],"models.":[38]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-04-05T00:00:00"}