{"id":"https://openalex.org/W4361819475","doi":"https://doi.org/10.1158/1055-9965.c.6515821","title":"Data from Construction and Analysis of the NCI-EDRN Breast Cancer Reference Set for Circulating Markers of Disease","display_name":"Data from Construction and Analysis of the NCI-EDRN Breast Cancer Reference Set for Circulating Markers of Disease","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361819475","doi":"https://doi.org/10.1158/1055-9965.c.6515821"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.c.6515821","doi":"https://doi.org/10.1158/1055-9965.c.6515821","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6515821","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1055-9965.c.6515821","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032566475","display_name":"Jeffrey R. Marks","orcid":"https://orcid.org/0000-0002-2054-5468","observed_orcids":["https://orcid.org/0000-0002-2054-5468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey R. Marks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033246326","display_name":"Karen S. Anderson","orcid":"https://orcid.org/0000-0002-3870-5730","observed_orcids":["https://orcid.org/0000-0002-3870-5730"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen S. Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112905116","display_name":"Paul F. Engstrom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Engstrom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033625395","display_name":"Andrew K. Godwin","orcid":"https://orcid.org/0000-0002-3987-9580","observed_orcids":["https://orcid.org/0000-0002-3987-9580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew K. Godwin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072789687","display_name":"Laura J. Esserman","orcid":"https://orcid.org/0000-0001-9202-4568","observed_orcids":["https://orcid.org/0000-0001-9202-4568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura J. Esserman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109949337","display_name":"Gary Longton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary Longton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088726636","display_name":"Edwin S. Iversen","orcid":"https://orcid.org/0000-0002-0066-2763","observed_orcids":["https://orcid.org/0000-0002-0066-2763"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edwin S. Iversen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087977671","display_name":"Anu Mathew","orcid":"https://orcid.org/0000-0003-3327-3083","observed_orcids":["https://orcid.org/0000-0003-3327-3083"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anu Mathew","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061198533","display_name":"Christos Patriotis","orcid":"https://orcid.org/0000-0001-6441-776X","observed_orcids":["https://orcid.org/0000-0001-6441-776X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christos Patriotis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109010710","display_name":"MARGARET SULLIVAN PEPE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margaret S. Pepe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.4683000147342682,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.4683000147342682,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.17990000545978546,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.1412000060081482,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.9929999709129333},{"id":"https://openalex.org/keywords/plasma-proteins","display_name":"plasma proteins","score":0.5239999890327454},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6800000071525574},{"id":"https://openalex.org/keywords/reference-set","display_name":"reference set","score":0.609000027179718},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.492000013589859},{"id":"https://openalex.org/keywords/ca125","display_name":"CA125","score":0.8610000014305115},{"id":"https://openalex.org/keywords/estrogen-receptor-negative-breast-cancer","display_name":"estrogen receptor-negative breast cancer","score":0.9419999718666077},{"id":"https://openalex.org/keywords/benign-breast-disease","display_name":"benign breast disease","score":0.671999990940094},{"id":"https://openalex.org/keywords/multiplex-immunoassay","display_name":"multiplex immunoassay","score":0.7770000100135803},{"id":"https://openalex.org/keywords/breast-cancer-screening","display_name":"breast cancer screening","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.765977144241333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7508856058120728},{"id":"https://openalex.org/C2780472235","wikidata":"https://www.wikidata.org/wiki/Q324634","display_name":"Mammography","level":4,"score":0.5843654274940491},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5544549226760864},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5383409857749939},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.45945459604263306},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3865646719932556},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.37673822045326233}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1055-9965.c.6515821","doi":"https://doi.org/10.1158/1055-9965.c.6515821","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6515821","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.c.6515821","doi":"https://doi.org/10.1158/1055-9965.c.6515821","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6515821","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2135748113","https://openalex.org/W1500586124","https://openalex.org/W2741435285","https://openalex.org/W2749723775","https://openalex.org/W2086424908","https://openalex.org/W1666949413","https://openalex.org/W3138735004","https://openalex.org/W4392238791","https://openalex.org/W2131463486","https://openalex.org/W2521458988"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Many":[2],"circulating":[3,53],"biomarkers":[4,54,74],"have":[5,18,240],"been":[6,243],"reported":[7],"for":[8,55,112,192,209,225],"the":[9,56,182],"diagnosis":[10,59,111],"of":[11,42,60,78,88,159,175,204,247],"breast":[12,61,82,113,160,235],"cancer,":[13],"but":[14],"few,":[15],"if":[16],"any,":[17],"undergone":[19],"rigorous":[20],"credentialing":[21],"using":[22,75,92],"prospective":[23],"cohorts":[24],"and":[25,44,58,154],"blinded":[26,79],"evaluation.":[27],"Methods:":[28],"The":[29,81,119],"NCI":[30],"Early":[31],"Detection":[32],"Research":[33],"Network":[34],"(EDRN)":[35],"has":[36],"created":[37],"a":[38,76,93,173,222],"prospective,":[39],"multicenter":[40],"collection":[41],"plasma":[43,176],"serum":[45],"samples":[46,64,90,123,177,250],"from":[47,102,106,124,181,212,237],"832":[48],"subjects":[49],"designed":[50],"to":[51,67,71,104,220],"evaluate":[52,72],"detection":[57],"cancer.":[62],"These":[63],"are":[65],"available":[66],"investigators":[68],"who":[69],"wish":[70],"their":[73,193],"set":[77,85,121],"samples.":[80],"cancer":[83,114,129,211,239],"reference":[84,120,183],"is":[86,207],"composed":[87],"blood":[89],"collected":[91,249],"standard":[94],"operating":[95],"procedure":[96],"at":[97],"four":[98],"U.S.":[99],"medical":[100],"centers":[101],"2008":[103],"2010":[105],"women":[107,125,155],"undergoing":[108],"either":[109],"tissue":[110],"or":[115,167],"routine":[116],"screening":[117,163],"mammography.":[118],"contains":[122],"with":[126,141,148,156],"incident":[127],"invasive":[128,238],"(n":[130,136,143,151,178],"=":[131,137,144,152,170,179],"190),":[132],"carcinoma":[133],"in":[134],"situ":[135],"55),":[138],"benign":[139,146,213,234],"pathology":[140],"atypia":[142,150],"63),":[145],"disease":[147,161],"no":[149,157],"231),":[153],"evidence":[158],"by":[162,189],"mammography":[164],"(BI-RADS":[165],"1":[166],"2,":[168],"n":[169],"276).":[171],"Using":[172],"subset":[174],"505)":[180],"set,":[184],"we":[185],"analyzed":[186],"90":[187],"proteins":[188],"multiplexed":[190],"immunoassays":[191],"potential":[194],"utility":[195],"as":[196],"diagnostic":[197],"markers.":[198],"Results:":[199],"We":[200],"found":[201],"that":[202,231],"none":[203],"these":[205],"markers":[206],"useful":[208],"distinguishing":[210],"controls.":[214],"However,":[215],"elevated":[216],"CA-125":[217],"does":[218],"appear":[219],"be":[221],"candidate":[223],"marker":[224],"estrogen":[226],"receptor\u2013negative":[227],"cancers.":[228],"Conclusions:":[229],"Markers":[230],"can":[232],"distinguish":[233],"conditions":[236],"not":[241],"yet":[242],"found.":[244],"Impact:":[245],"Availability":[246],"prospectively":[248],"should":[251],"improve":[252],"future":[253],"validation":[254],"efforts.":[255],"Cancer":[256],"Epidemiol":[257],"Biomarkers":[258],"Prev;":[259],"24(2);":[260],"435\u201341.":[261],"\u00a92014":[262],"AACR.":[263]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-05T00:00:00"}
