{"id":"https://openalex.org/W4361819161","doi":"https://doi.org/10.1158/1078-0432.22443297","title":"Supplementary Figures S1-S5 from Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth","display_name":"Supplementary Figures S1-S5 from Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361819161","doi":"https://doi.org/10.1158/1078-0432.22443297"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22443297","doi":"https://doi.org/10.1158/1078-0432.22443297","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22443297","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.22443297","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057642803","display_name":"Nagathihalli S. Nagaraj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nagathihalli S. Nagaraj","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087826096","display_name":"Mary Kay Washington","orcid":"https://orcid.org/0000-0002-9589-7695","observed_orcids":["https://orcid.org/0000-0002-9589-7695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Kay Washington","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016606073","display_name":"Nipun B. Merchant","orcid":"https://orcid.org/0000-0002-3399-9776","observed_orcids":["https://orcid.org/0000-0002-3399-9776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nipun B. Merchant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.8989999890327454},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9620000123977661},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8069999814033508},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8550000190734863},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7289999723434448},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.7712041735649109},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.5546424388885498},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.5417772531509399},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5258553624153137},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5247547626495361},{"id":"https://openalex.org/C130287650","wikidata":"https://www.wikidata.org/wiki/Q17091190","display_name":"Growth factor receptor inhibitor","level":4,"score":0.43585509061813354},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.42082667350769043},{"id":"https://openalex.org/C3020076753","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic carcinoma","level":4,"score":0.42030981183052063},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38171911239624023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35134369134902954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32494857907295227},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3118740916252136},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.21816256642341614},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.09835439920425415},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07886901497840881}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.22443297","doi":"https://doi.org/10.1158/1078-0432.22443297","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22443297","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22443297.v1","doi":"https://doi.org/10.1158/1078-0432.22443297.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22443297.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39894258","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22443297","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figures_S1-S5_from_Combined_Blockade_of_Src_Kinase_and_Epidermal_Growth_Factor_Receptor_with_Gemcitabine_Overcomes_STAT3-Mediated_Resistance_of_Inhibition_of_Pancreatic_Tumor_Growth/22443297","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22443297","doi":"https://doi.org/10.1158/1078-0432.22443297","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22443297","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361819161.pdf","grobid_xml":"https://content.openalex.org/works/W4361819161.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070752135","https://openalex.org/W4361819624","https://openalex.org/W4361827671","https://openalex.org/W4392699721","https://openalex.org/W2998813908","https://openalex.org/W2996302935","https://openalex.org/W2136475581","https://openalex.org/W2740472610","https://openalex.org/W2321209106","https://openalex.org/W2162369060"],"abstract_inverted_index":{"Supplementary":[0],"Figures":[1],"S1-S5.":[2]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}