{"id":"https://openalex.org/W4361817377","doi":"https://doi.org/10.1158/0008-5472.c.6507917.v1","title":"Data from Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype","display_name":"Data from Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361817377","doi":"https://doi.org/10.1158/0008-5472.c.6507917.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6507917.v1","doi":"https://doi.org/10.1158/0008-5472.c.6507917.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507917.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6507917.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100435324","display_name":"Ling Li","orcid":"https://orcid.org/0000-0002-0087-3034","observed_orcids":["https://orcid.org/0000-0002-0087-3034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323171","display_name":"Chao Li","orcid":"https://orcid.org/0000-0002-1900-8008","observed_orcids":["https://orcid.org/0000-0002-1900-8008"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chao Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101491473","display_name":"Shaoxin Wang","orcid":"https://orcid.org/0009-0003-0415-3645","observed_orcids":["https://orcid.org/0009-0003-0415-3645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaoxin Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100358033","display_name":"Zhaohui Wang","orcid":"https://orcid.org/0000-0001-7994-7464","observed_orcids":["https://orcid.org/0000-0001-7994-7464"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhaohui Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100669098","display_name":"Jian Jiang","orcid":"https://orcid.org/0000-0001-5886-8732","observed_orcids":["https://orcid.org/0000-0001-5886-8732","https://orcid.org/0000-0002-5994-292X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100391941","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0002-3422-0402","observed_orcids":["https://orcid.org/0000-0002-3422-0402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348756","display_name":"Xiaoxia Li","orcid":"https://orcid.org/0000-0002-4872-9525","observed_orcids":["https://orcid.org/0000-0002-4872-9525"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoxia Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394908","display_name":"Jing Chen","orcid":"https://orcid.org/0000-0002-6284-2858","observed_orcids":["https://orcid.org/0000-0002-6284-2858","https://orcid.org/0000-0001-9971-1053"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398799","display_name":"Kun Liu","orcid":"https://orcid.org/0000-0003-1366-4546","observed_orcids":["https://orcid.org/0000-0003-1366-4546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kun Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100781358","display_name":"Chunhua Li","orcid":"https://orcid.org/0000-0002-9947-6855","observed_orcids":["https://orcid.org/0000-0002-9947-6855"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunhua Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000700564","display_name":"Guiquan Zhu","orcid":"https://orcid.org/0000-0002-8316-5809","observed_orcids":["https://orcid.org/0000-0002-8316-5809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guiquan Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8569999933242798},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hif-2alpha","display_name":"HIF-2\u03b1","score":1.0},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6830000281333923},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8690000176429749},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.7960000038146973},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.8410000205039978},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8930000066757202},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.8813447952270508},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.68180912733078},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6566554307937622},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5854430198669434},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5151699781417847},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4975183308124542},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4629116654396057},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.43832188844680786},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.42526185512542725},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.38793057203292847},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3304021954536438},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25465577840805054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2067679464817047},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05636170506477356},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6507917.v1","doi":"https://doi.org/10.1158/0008-5472.c.6507917.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507917.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6507917.v1","doi":"https://doi.org/10.1158/0008-5472.c.6507917.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507917.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2301890235","https://openalex.org/W4377695294","https://openalex.org/W3181088782","https://openalex.org/W4288723307","https://openalex.org/W3162050958","https://openalex.org/W3092229267","https://openalex.org/W2566057223","https://openalex.org/W4292499079","https://openalex.org/W2025871852","https://openalex.org/W3035179765"],"abstract_inverted_index":{"Abstract":[0],"Hypoxia":[1],"is":[2,10],"a":[3,77],"common":[4],"feature":[5],"of":[6,73,99,118,149,241],"solid":[7],"tumors":[8],"and":[9,14,44,71,79,101,140,145,154,161,169,182,198,233],"associated":[11,192],"with":[12,32,193,204],"aggressiveness":[13],"poor":[15],"patient":[16],"outcomes.":[17],"Exosomes,":[18],"initially":[19],"considered":[20],"to":[21,88,91,134,219,226,229],"be":[22],"cellular":[23,34,93],"\u201cgarbage":[24],"dumpsters,\u201d":[25],"are":[26,224],"now":[27],"implicated":[28],"in":[29,76,129,138,152,177,180,183,202],"mediating":[30],"interactions":[31],"the":[33,37,40,69,106,119,212,238],"environment.":[35],"However,":[36],"mechanisms":[38],"underlying":[39],"association":[41],"between":[42],"exosomes":[43,58,84,139,156,222],"hypoxia":[45],"during":[46],"cancer":[47,245],"progression":[48],"remain":[49],"poorly":[50],"understood.":[51],"In":[52,206],"this":[53],"study,":[54],"we":[55,95],"found":[56],"that":[57,83,109,211,223],"derived":[59],"from":[60],"hypoxic":[61,102,125,130,213],"oral":[62],"squamous":[63],"cell":[64,143,159],"carcinoma":[65],"(OSCC)":[66],"cells":[67,75,132,218,228],"increased":[68],"migration":[70,144,160],"invasion":[72],"OSCC":[74,131,158,178],"HIF-1\u03b1":[78,153],"HIF-2\u03b1\u2013dependent":[80],"manner.":[81],"Given":[82],"have":[85],"been":[86],"shown":[87],"transport":[89],"miRNAs":[90,108,123],"alter":[92],"functions,":[94],"performed":[96],"miRNA":[97],"sequencing":[98],"normoxic":[100,227],"OSCC-derived":[103],"exosomes.":[104],"Of":[105],"108":[107],"were":[110,190],"differentially":[111],"expressed,":[112],"miR-21":[113,127,136,150,165,188],"stood":[114],"out":[115],"as":[116],"one":[117],"most":[120],"significantly":[121,141,173],"upregulated":[122],"under":[124],"conditions.":[126],"depletion":[128],"led":[133],"decreased":[135],"levels":[137,176,189],"reduced":[142],"invasion.":[146,162],"Conversely,":[147],"restoration":[148],"expression":[151],"HIF-2\u03b1\u2013depleted":[155],"rescued":[157],"Moreover,":[163],"exosomal":[164,187],"markedly":[166],"enhanced":[167],"snail":[168],"vimentin":[170],"expression,":[171,195],"while":[172],"decreasing":[174],"E-cadherin":[175],"cells,":[179],"vitro":[181],"vivo.":[184],"Finally,":[185],"circulating":[186],"closely":[191],"HIF-1\u03b1/HIF-2\u03b1":[194],"T":[196],"stage,":[197],"lymph":[199],"node":[200],"metastasis":[201],"patients":[203],"OSCC.":[205],"conclusion,":[207],"our":[208],"findings":[209],"suggest":[210],"microenvironment":[214],"may":[215],"stimulate":[216],"tumor":[217],"generate":[220],"miR-21\u2013rich":[221],"delivered":[225],"promote":[230],"prometastatic":[231],"behaviors":[232],"prompt":[234],"further":[235],"investigation":[236],"into":[237],"therapeutic":[239],"value":[240],"exosome":[242],"inhibition":[243],"for":[244],"treatment.":[246],"Cancer":[247],"Res;":[248],"76(7);":[249],"1770\u201380.":[250],"\u00a92016":[251],"AACR.":[252]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2023-04-05T00:00:00"}