{"id":"https://openalex.org/W4361815744","doi":"https://doi.org/10.1158/0008-5472.c.6507752","title":"Data from Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease","display_name":"Data from Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361815744","doi":"https://doi.org/10.1158/0008-5472.c.6507752"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6507752","doi":"https://doi.org/10.1158/0008-5472.c.6507752","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6507752","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.6507752","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stephen J. Murphy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen J. Murphy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085507659","display_name":"Steven N. Hart","orcid":"https://orcid.org/0000-0001-7714-2734","observed_orcids":["https://orcid.org/0000-0001-7714-2734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven N. Hart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001401473","display_name":"Geoffrey C. Halling","orcid":"https://orcid.org/0009-0003-3857-3576","observed_orcids":["https://orcid.org/0009-0003-3857-3576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoffrey C. Halling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051491336","display_name":"Sarah H. Johnson","orcid":"https://orcid.org/0000-0001-7412-5322","observed_orcids":["https://orcid.org/0000-0001-7412-5322"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah H. Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077968996","display_name":"James B. Smadbeck","orcid":"https://orcid.org/0000-0002-8902-0950","observed_orcids":["https://orcid.org/0000-0002-8902-0950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James B. Smadbeck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016273546","display_name":"Travis Drucker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Travis Drucker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048264161","display_name":"Joema Felipe Lima","orcid":"https://orcid.org/0000-0003-4344-2434","observed_orcids":["https://orcid.org/0000-0003-4344-2434"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joema Felipe Lima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049276540","display_name":"Fariborz Rakhshan Rohakhtar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fariborz Rakhshan Rohakhtar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108213816","display_name":"Faye R. Harris","orcid":"https://orcid.org/0000-0001-6356-8910","observed_orcids":["https://orcid.org/0000-0001-6356-8910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Faye R. Harris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070480124","display_name":"Farhad Kosari","orcid":"https://orcid.org/0000-0003-0321-164X","observed_orcids":["https://orcid.org/0000-0003-0321-164X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farhad Kosari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003500740","display_name":"Subbaya Subramanian","orcid":"https://orcid.org/0000-0002-2544-480X","observed_orcids":["https://orcid.org/0000-0002-2544-480X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Subbaya Subramanian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048782070","display_name":"Gloria M. Petersen","orcid":"https://orcid.org/0000-0003-3424-7039","observed_orcids":["https://orcid.org/0000-0003-3424-7039"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gloria M. Petersen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049915049","display_name":"Timothy D. Wiltshire","orcid":"https://orcid.org/0000-0003-1375-4015","observed_orcids":["https://orcid.org/0000-0003-1375-4015"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy D. Wiltshire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023410987","display_name":"Benjamin R. Kipp","orcid":"https://orcid.org/0000-0001-9477-0118","observed_orcids":["https://orcid.org/0000-0001-9477-0118"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin R. Kipp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029404091","display_name":"Mark Joseph Truty","orcid":"https://orcid.org/0000-0003-3776-527X","observed_orcids":["https://orcid.org/0000-0003-3776-527X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark J. Truty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006194799","display_name":"Robert R. McWilliams","orcid":"https://orcid.org/0000-0002-8199-5040","observed_orcids":["https://orcid.org/0000-0002-8199-5040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert R. McWilliams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016908886","display_name":"Fergus J. Couch","orcid":"https://orcid.org/0000-0001-9417-9985","observed_orcids":["https://orcid.org/0000-0001-9417-9985"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fergus J. Couch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021419381","display_name":"George Vasmatzis","orcid":"https://orcid.org/0000-0002-3401-3497","observed_orcids":["https://orcid.org/0000-0002-3401-3497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Vasmatzis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.08780000358819962,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/genomic-rearrangements","display_name":"genome rearrangement","score":0.9070000052452087},{"id":"https://openalex.org/keywords/smad4","display_name":"SMAD4","score":0.9300000071525574},{"id":"https://openalex.org/keywords/fhit","display_name":"FHIT","score":0.8930000066757202},{"id":"https://openalex.org/keywords/znf521","display_name":"ZNF521","score":0.9929999709129333},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.671999990940094},{"id":"https://openalex.org/keywords/gata6","display_name":"GATA6","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.7960000038146973},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/copy-number-gain","display_name":"copy number gain","score":0.7459999918937683},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.6959999799728394},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7054170966148376},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5943855047225952},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5529994368553162},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.533139705657959},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5144591331481934},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4896467328071594},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48288702964782715},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.15923821926116943},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14916884899139404},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.10738790035247803}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6507752","doi":"https://doi.org/10.1158/0008-5472.c.6507752","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6507752","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6507752","doi":"https://doi.org/10.1158/0008-5472.c.6507752","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.6507752","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.44999998807907104,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3029979236","https://openalex.org/W3000738194","https://openalex.org/W2123037811","https://openalex.org/W2919381586","https://openalex.org/W2789881781","https://openalex.org/W2002128513","https://openalex.org/W2017372544","https://openalex.org/W2028090716","https://openalex.org/W3025961873","https://openalex.org/W3012091774"],"abstract_inverted_index":{"Abstract":[0],"Many":[1],"somatic":[2],"mutations":[3],"have":[4],"been":[5,32],"detected":[6,78],"in":[7,74,79,108,142,156],"pancreatic":[8],"ductal":[9],"adenocarcinoma":[10],"(PDAC),":[11],"leading":[12],"to":[13,59,186],"the":[14,24,88,109,200],"identification":[15],"of":[16,20,26,111,126,135,181,196,202],"some":[17],"key":[18,70,194],"drivers":[19,195],"disease":[21,213],"progression,":[22],"but":[23],"involvement":[25],"large":[27],"genomic":[28,44,64,187,205],"rearrangements":[29,65,147,188],"has":[30],"often":[31],"overlooked.":[33],"In":[34],"this":[35],"study,":[36],"we":[37],"performed":[38],"mate":[39],"pair":[40],"sequencing":[41],"(MPseq)":[42],"on":[43],"DNA":[45],"from":[46,128],"24":[47],"PDAC":[48,54,75,123,137,163],"tumors,":[49],"including":[50,101],"15":[51],"laser-captured":[52],"microdissected":[53],"and":[55,84,103,132,148,172,175,183,206,215],"9":[56],"patient-derived":[57],"xenografts,":[58],"identify":[60],"genome-wide":[61],"rearrangements.":[62],"Large":[63],"with":[66,97,161],"intragenic":[67,113],"breakpoints":[68],"altering":[69],"regulatory":[71],"genes":[72,96,143,192],"involved":[73],"progression":[76],"were":[77,86,105],"all":[80,162],"tumors.":[81],"SMAD4,":[82],"ZNF521,":[83],"FHIT":[85,184],"among":[87],"most":[89],"frequently":[90,106],"hit":[91],"genes.":[92],"Conversely,":[93],"commonly":[94],"reported":[95],"copy":[98],"number":[99],"gains,":[100],"MYC":[102],"GATA6,":[104],"observed":[107,155],"absence":[110],"direct":[112],"breakpoints,":[114],"suggesting":[115],"a":[116],"requirement":[117],"for":[118,209],"sustaining":[119],"oncogenic":[120],"function":[121],"during":[122],"progression.":[124,216],"Integration":[125],"data":[127],"MPseq,":[129],"exome":[130],"sequencing,":[131],"transcriptome":[133],"analysis":[134],"primary":[136],"cases":[138],"identified":[139],"limited":[140],"overlap":[141,153],"affected":[144],"by":[145],"both":[146],"point":[149],"mutations.":[150],"However,":[151],"significant":[152],"was":[154],"major":[157],"PDAC-associated":[158],"signaling":[159],"pathways,":[160],"exhibiting":[164],"reduced":[165,168],"SMAD4":[166,182],"expression,":[167],"SMAD-dependent":[169],"TGF\u03b2":[170],"signaling,":[171],"increased":[173],"WNT":[174],"Hedgehog":[176],"signaling.":[177],"The":[178],"frequent":[179],"loss":[180],"due":[185],"strongly":[189],"implicates":[190],"these":[191],"as":[193],"PDAC,":[197],"thus":[198],"highlighting":[199],"strengths":[201],"an":[203],"integrated":[204],"transcriptomic":[207],"approach":[208],"identifying":[210],"mechanisms":[211],"underlying":[212],"initiation":[214],"Cancer":[217],"Res;":[218],"76(3);":[219],"749\u201361.":[220],"\u00a92015":[221],"AACR.":[222]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}