{"id":"https://openalex.org/W4361815557","doi":"https://doi.org/10.1158/0008-5472.c.6507894","title":"Data from MCPIP1 Selectively Destabilizes Transcripts Associated with an Antiapoptotic Gene Expression Program in Breast Cancer Cells That Can Elicit Complete Tumor Regression","display_name":"Data from MCPIP1 Selectively Destabilizes Transcripts Associated with an Antiapoptotic Gene Expression Program in Breast Cancer Cells That Can Elicit Complete Tumor Regression","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361815557","doi":"https://doi.org/10.1158/0008-5472.c.6507894"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6507894","doi":"https://doi.org/10.1158/0008-5472.c.6507894","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507894","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W4361815557"],"child_works_count":0,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6507894","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049012803","display_name":"Wenbao Lu","orcid":"https://orcid.org/0000-0001-6577-3379","observed_orcids":["https://orcid.org/0000-0001-6577-3379"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenbao Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048472635","display_name":"Huan Ning","orcid":"https://orcid.org/0000-0003-3698-3240","observed_orcids":["https://orcid.org/0000-0003-3698-3240"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huan Ning","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102284758","display_name":"Ling Gu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Gu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357503","display_name":"Hui Peng","orcid":"https://orcid.org/0000-0002-2000-1647","observed_orcids":["https://orcid.org/0000-0002-2000-1647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Peng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004018057","display_name":"Qinghong Wang","orcid":"https://orcid.org/0000-0003-0432-0741","observed_orcids":["https://orcid.org/0000-0003-0432-0741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qinghong Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010225963","display_name":"Rong Hou","orcid":"https://orcid.org/0000-0002-8236-6318","observed_orcids":["https://orcid.org/0000-0002-8236-6318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rong Hou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037008514","display_name":"Mingui Fu","orcid":"https://orcid.org/0000-0001-6315-8372","observed_orcids":["https://orcid.org/0000-0001-6315-8372"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingui Fu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029815230","display_name":"Daniel Fredric Hoft","orcid":"https://orcid.org/0000-0002-8921-4093","observed_orcids":["https://orcid.org/0000-0002-8921-4093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel F. Hoft","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Jianguo Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianguo Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.18770000338554382,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mcpip1","display_name":"MCPIP1","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8130000233650208},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/anti-apoptotic-gene-expression","display_name":"anti-apoptotic gene expression","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mrna-degradation","display_name":"mRNA degradation","score":0.871999979019165},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.7210000157356262},{"id":"https://openalex.org/keywords/pin-domain","display_name":"PIN domain","score":0.8519999980926514},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.8840000033378601},{"id":"https://openalex.org/keywords/bcl2a1","display_name":"BCL2A1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/relb","display_name":"RelB","score":0.9449999928474426},{"id":"https://openalex.org/keywords/ciap2","display_name":"cIAP2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/boron-trichloride","display_name":"boron trichloride","score":0.9700000286102295},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.8989999890327454},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7059999704360962},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6404157876968384},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.586324155330658},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49618273973464966},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.45926085114479065},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4347441494464874},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4313443899154663},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4257931709289551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4071471691131592},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3407120108604431},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31539636850357056},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06010448932647705}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.c.6507894","doi":"https://doi.org/10.1158/0008-5472.c.6507894","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507894","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.c.6507894.v1","doi":"https://doi.org/10.1158/0008-5472.c.6507894.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507894.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6507894","doi":"https://doi.org/10.1158/0008-5472.c.6507894","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507894","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2263968686","https://openalex.org/W2565505635","https://openalex.org/W2980917397","https://openalex.org/W2794135786","https://openalex.org/W2772046490","https://openalex.org/W2163645436","https://openalex.org/W2248373744","https://openalex.org/W4389020165","https://openalex.org/W2101314927","https://openalex.org/W2051928563"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"ability":[2],"of":[3,44,63,87,96,120,144,164,194,220],"cancer":[4,48,152,183,209],"cells":[5,90],"to":[6],"evade":[7],"apoptosis":[8,66,86],"is":[9,30,202],"dictated":[10],"by":[11,91,214],"a":[12,31,60,80,112,168,203],"shift":[13],"in":[14,39,46,54,65,115,138,158,161,171,178,207,218],"the":[15,116,216],"balance":[16,217],"between":[17],"proapoptotic":[18,221],"and":[19,105,142,167],"antiapoptotic":[20,97],"gene":[21,98,222],"expression":[22,135,177],"programs.":[23],"Monocyte":[24],"chemotactic":[25],"protein-induced":[26],"protein":[27,35],"1":[28],"(MCPIP1)":[29],"zinc-finger":[32],"RNA":[33],"binding":[34],"with":[36,111,188],"important":[37],"roles":[38],"mediating":[40],"inflammatory":[41],"responses.":[42],"Overexpression":[43],"MCPIP1":[45,64,77,108,134,145,156,176,201],"different":[47],"cell":[49,153,212],"types":[50],"has":[51,67],"been":[52,69],"implicated":[53],"eliciting":[55],"an":[56],"antitumor":[57],"response,":[58],"but":[59],"direct":[61],"role":[62],"not":[68],"established.":[70],"In":[71],"this":[72],"study,":[73],"we":[74,131],"demonstrate":[75],"that":[76,84,133,200,210],"functions":[78],"as":[79],"potent":[81],"tumor":[82,89,140,179,205],"suppressor":[83,206],"induces":[85,211],"breast":[88,139,182,208],"selectively":[92],"enhancing":[93],"mRNA":[94,128],"decay":[95],"transcripts,":[99],"including":[100],"Bcl2L1,":[101],"Bcl2A1,":[102],"RelB,":[103],"Birc3,":[104],"Bcl3.":[106],"Mechanistically,":[107],"physically":[109],"interacted":[110],"stem\u2013loop":[113],"structure":[114],"3\u2032":[117],"untranslated":[118],"region":[119],"these":[121],"transcripts":[122],"through":[123],"its":[124,149],"PIN":[125],"domain,":[126],"causing":[127],"destabilization.":[129],"Furthermore,":[130],"found":[132],"was":[136,185],"repressed":[137],"cells,":[141],"overexpression":[143],"induced":[146],"apoptosis,":[147],"whereas":[148],"depletion":[150],"enhanced":[151],"proliferation.":[154],"Moreover,":[155],"induction":[157],"vivo":[159],"resulted":[160],"complete":[162],"regression":[163],"established":[165],"tumors":[166],"significant":[169],"reduction":[170],"metastatic":[172],"disease.":[173],"Notably,":[174],"low":[175],"samples":[180],"from":[181],"patients":[184],"strongly":[186],"associated":[187],"poor":[189],"survival":[190],"over":[191],"13":[192],"years":[193],"follow-up.":[195],"Collectively,":[196],"our":[197],"results":[198],"highlight":[199],"new":[204],"death":[213],"tipping":[215],"favor":[219],"expression.":[223],"Cancer":[224],"Res;":[225],"76(6);":[226],"1429\u201340.":[227],"\u00a92016":[228],"AACR.":[229]},"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2023-04-05T00:00:00"}