{"id":"https://openalex.org/W4361815534","doi":"https://doi.org/10.1158/0008-5472.c.6507812","title":"Data from Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis","display_name":"Data from Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361815534","doi":"https://doi.org/10.1158/0008-5472.c.6507812"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6507812","doi":"https://doi.org/10.1158/0008-5472.c.6507812","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507812","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.c.6507812","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089552341","display_name":"Yabin Guo","orcid":"https://orcid.org/0000-0001-8316-8527","observed_orcids":["https://orcid.org/0000-0001-8316-8527"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yabin Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076880628","display_name":"Barrett L. Updegraff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barrett L. Updegraff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101989627","display_name":"Sunho Park","orcid":"https://orcid.org/0000-0001-8158-6506","observed_orcids":["https://orcid.org/0000-0001-8158-6506"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunho Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082924789","display_name":"Deniz Durakoglugil","orcid":"https://orcid.org/0000-0003-2393-7528","observed_orcids":["https://orcid.org/0000-0003-2393-7528"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deniz Durakoglugil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006843637","display_name":"Victoria H. Cruz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victoria H. Cruz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087633524","display_name":"Sarah Maddux","orcid":"https://orcid.org/0000-0002-7160-566X","observed_orcids":["https://orcid.org/0000-0002-7160-566X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah Maddux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027668952","display_name":"Tae Hyun Hwang","orcid":"https://orcid.org/0000-0002-6668-7269","observed_orcids":["https://orcid.org/0000-0002-6668-7269"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tae Hyun Hwang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051202620","display_name":"Kathryn A. O\u2019Donnell","orcid":"https://orcid.org/0000-0003-2215-1064","observed_orcids":["https://orcid.org/0000-0003-2215-1064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathryn A. O'Donnell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.7910000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.7910000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.07919999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sleeping-beauty-transposon","display_name":"Sleeping Beauty transposon","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ba-f3-cells","display_name":"Ba/F3 cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.859000027179718},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytokine-receptor-signaling","display_name":"cytokine receptor signaling","score":0.8059999942779541},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.6039999723434448},{"id":"https://openalex.org/keywords/functional-screening","display_name":"functional screening","score":0.33500000834465027},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7288594841957092},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.507958710193634},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4996767044067383},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49460718035697937},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48287084698677063},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4497950077056885},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.44548431038856506},{"id":"https://openalex.org/C28693550","wikidata":"https://www.wikidata.org/wiki/Q7835335","display_name":"Transposon mutagenesis","level":5,"score":0.43009454011917114},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.4252898395061493},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4080830216407776},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40005791187286377},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.25403788685798645},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.1637984812259674}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6507812","doi":"https://doi.org/10.1158/0008-5472.c.6507812","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507812","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6507812","doi":"https://doi.org/10.1158/0008-5472.c.6507812","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.c.6507812","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2206856591","https://openalex.org/W2249433147","https://openalex.org/W1995521807","https://openalex.org/W1640321573","https://openalex.org/W2207070375","https://openalex.org/W2589199950","https://openalex.org/W4388485679","https://openalex.org/W2578398419","https://openalex.org/W2903937791","https://openalex.org/W7042016306"],"abstract_inverted_index":{"Abstract":[0],"Aberrant":[1],"signaling":[2,9,100,172,200],"through":[3],"cytokine":[4,68,99,171,199],"receptors":[5],"and":[6,28,70,84,157,173,191],"their":[7],"downstream":[8],"pathways":[10,24,137],"is":[11],"a":[12,39,109,179],"major":[13],"oncogenic":[14,96],"mechanism":[15],"underlying":[16],"hematopoietic":[17,35],"malignancies.":[18],"To":[19],"better":[20],"understand":[21],"how":[22],"these":[23,148],"become":[25],"pathologically":[26],"activated":[27],"to":[29,79,93,118,132,140,143],"potentially":[30],"identify":[31,94],"new":[32,167,193],"drivers":[33],"of":[34,59,90,98,112,147,198],"cancers,":[36],"we":[37],"developed":[38],"high-throughput":[40],"functional":[41],"screening":[42],"approach":[43,164,182],"using":[44],"ex":[45],"vivo":[46],"mutagenesis":[47],"with":[48,125],"the":[49,82,88,133,196],"Sleeping":[50],"Beauty":[51],"transposon.":[52],"We":[53],"analyzed":[54],"over":[55],"1,100":[56],"transposon-mutagenized":[57],"pools":[58],"Ba/F3":[60],"cells,":[61],"an":[62],"IL3-dependent":[63],"pro-B-cell":[64],"line,":[65],"which":[66],"acquired":[67],"independence":[69],"tumor-forming":[71],"ability.":[72],"Recurrent":[73],"transposon":[74],"insertions":[75,105],"could":[76],"be":[77,119],"mapped":[78],"genes":[80,113,150,168,187],"in":[81,108,121,152,155,159,188],"JAK/STAT":[83,134],"MAPK":[85,136],"pathways,":[86],"confirming":[87],"ability":[89],"this":[91,162],"strategy":[92],"known":[95],"components":[97],"pathways.":[101],"In":[102],"addition,":[103],"recurrent":[104],"were":[106,128],"identified":[107],"large":[110],"set":[111],"that":[114,169],"have":[115],"been":[116],"found":[117],"mutated":[120],"leukemia":[122,202],"or":[123,135],"associated":[124],"survival,":[126],"but":[127],"not":[129],"previously":[130],"linked":[131],"nor":[138],"shown":[139],"functionally":[141,185],"contribute":[142],"leukemogenesis.":[144,174],"Forced":[145],"expression":[146],"novel":[149],"resulted":[151],"IL3-independent":[153],"growth":[154],"vitro":[156],"tumorigenesis":[158],"vivo,":[160],"validating":[161],"mutagenesis-based":[163],"for":[165,183],"identifying":[166],"promote":[170],"Therefore,":[175],"our":[176],"findings":[177],"provide":[178],"broadly":[180],"applicable":[181],"classifying":[184],"relevant":[186],"diverse":[189],"malignancies":[190],"offer":[192],"insights":[194],"into":[195],"impact":[197],"on":[201],"development.":[203],"Cancer":[204],"Res;":[205],"76(4);":[206],"773\u201386.":[207],"\u00a92015":[208],"AACR.":[209]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2023-04-05T00:00:00"}
